Cytotoxic Neoflavonoids and Chalcones from the Heartwood of Dalbergia melanoxylon

N-Hydroxy-Phe-Phe, a new dipeptide, and cytotoxic macrocyclic trichothecenes from the lethal toxic mushroom Podostroma cornu-damae

“…Given the origin of the isolated macrocyclic trichothecenes from the highly toxic mushroom P. cornu-damae and the known potent cytotoxic properties of trichothecene analogues, we also conducted in vitro cytotoxicity evaluations of all the isolated compounds ( 1–4 ) in this study. The cytotoxicity was assessed against four human-derived cancer cell lines, SK-OV-3, SK-MEL-2, A549, and HCT15, using the SRB bioassay, 15–20 with doxorubicin serving as the positive control. As shown in Table 2, 12′-episatratoxin H ( 3 ) exhibited potent cytotoxic effects against all four cell lines tested, with IC 50 values in the range of 0.7–2.8 nM, which were stronger than that of doxorubicin, and satratoxin H ( 2 ) showed moderate cytotoxic potency against all four cell lines, with IC 50 values in the range of 1.93–4.22 μM, whereas N -hydroxy-Phe-Phe ( 1 ) and roridin F ( 4 ) did not show any significant cytotoxicity (IC 50 , >10.0).…”