Cytotoxic lactam and naphthoquinone alkaloids from roots of Goniothalamus lanceolatus Miq.

Rasol, Nurulfazlina Edayah; Ahmad, Fauziah; Lim, Xiang Yin; Chung, Felicia Fei‐Lei; Leong, Chee Onn; Wai, Chun-Tao; Bihud, Nur Vicky; Zaki, Hamizah Mohd; Ismail, Nor Hadiani

doi:10.1016/j.phytol.2018.01.009

Cited by 13 publications

(13 citation statements)

References 12 publications

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“…is an ethnomedicinal plant indigenous to Sarawak, Malaysia, used as traditional remedy for fever, skin infection, postpartum, abortion, as well as cancer treatment [1]. We previously reported cytotoxic lactam alkaloid and naphthoquinones from the roots of this plant [2]. Generally, Goniothalamus species are dominated by presences of styryl lactones.…”

mentioning

confidence: 99%

Styryl Lactones from Roots and Barks Goniothalamus lanceolatus

Rasol

Ahmad

Mai

et al. 2018

Natural Product Communications

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mentioning

confidence: 99%

Styryl Lactones from Roots and Barks Goniothalamus lanceolatus

Rasol

Ahmad

Mai

et al. 2018

Natural Product Communications

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“…Arun et al (2017) isolated pyranocarbazole alkaloids from the leaves and flowers of Murraya koenigii, from which murrayazoline 61 and O -methylmurrayamine A 62 showed potent anticancer activity in DLD-1coloncancercells [ 102 ], with IC 50 values of 5.7 mM and 17.9 mM, respectively. An alkaloid isolated from Goniothalamus lanceolatus , namely, goniolanceolactam 63 , showed potent cytotoxicity against the colon cell line with IC 50 value of 5.32 µM [ 103 ]. A schematic representation of molecular pathways of the anticancer effect of steroidal alkaloids in colon cancer is presented in Figure 1 .…”

Section: Activity Of Alkaloids Against Colon Cancermentioning

confidence: 99%

Alkaloids and Colon Cancer: Molecular Mechanisms and Therapeutic Implications for Cell Cycle Arrest

et al. 2022

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Cancer is the second most fatal disease worldwide, with colon cancer being the third most prevalent and fatal form of cancer in several Western countries. The risk of acquisition of resistance to chemotherapy remains a significant hurdle in the management of various types of cancer, especially colon cancer. Therefore, it is essential to develop alternative treatment modalities. Naturally occurring alkaloids have been shown to regulate various mechanistic pathways linked to cell proliferation, cell cycle, and metastasis. This review aims to shed light on the potential of alkaloids as anti-colon-cancer chemotherapy agents that can modulate or arrest the cell cycle. Preclinical investigated alkaloids have shown anti-colon cancer activities and inhibition of cancer cell proliferation via cell cycle arrest at different stages, suggesting that alkaloids may have the potential to act as anticancer molecules.

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“…White solid (CH 2 Cl 2 : MeOH 19 . The 13 .99 (C-11), 19.53 (C-21), 19.08 (C-26), 18.78 (C-27), 18.59 (C-19), 11.71 (C-29), 11.66 (C-18). The 13 C NMR spectral data was compared with literature 19 (Figure 1).…”

Section: Stigmasterol Glucoside (2)mentioning

confidence: 99%

In vitro Evaluation of Crude Extracts and Isolated Compounds from Goniothalamus rongklanus and Goniothalamus latestigma for Bioactive Properties

Funnimid

Pompimon

Nuntasaen³

2019

Journal of Natural Remedies

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The genus Goniothalamus belongs to the Annonaceae family. The pure compounds from Goniothalamus rongklanus and Goniothalamus latestigma were isolated by repeated column chromatography. The structures were recognized by NMR spectral methods. The chemical compounds of ethyl acetate extract (EtOAc) from the stems of G. rongklanus were identified as goniotriol (1) and stigmasterol glucoside (2). The EtOAc leaves extract of G. latestigma yielded a compound, which was identified as pinocembrin (3). The ethyl acetate (EtOAc) and methanol (MeOH) extract were tested for anti-HIV-1 RT and cytotoxic activities against P-388, KB, HT 29, MCF-7, A 549, ASK and CL cell lines. The EtOAc and MeOH extract of G. rongklanus showed evidence of anti-HIV-1 RT inhibition at 76.44 and 88.48 %, respectively. The EtOAc extract of G. rongklanus and G. latestigma showed cytotoxic activities on KB and HT 29 with an ED 50 at <4 µg/mL. In addition, antibacterial study on extracts and isolated compounds was also performed. Antibacterial study was evaluated using nine strains (Staphylococcus aureus, Enterobacter aerogenes, Escherichia coli 0157: H7, Escherichia coli (ETEC), Escherichia coli (EPEC), Proteus mirabilis, Salmonella typhimuriam, Shigella flexneri and Vibrio cholera) by Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) method. Goniotriol was the most effective antibacterial with a MIC in the range <0.16 -0.6 mg/mL and MBC in the range 0.3 ->5 mg/mL. The antibacterial activity of goniotriol has been reported for the first time.

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Cytotoxic lactam and naphthoquinone alkaloids from roots of Goniothalamus lanceolatus Miq.

Cited by 13 publications

References 12 publications

Styryl Lactones from Roots and Barks Goniothalamus lanceolatus

Styryl Lactones from Roots and Barks Goniothalamus lanceolatus

Alkaloids and Colon Cancer: Molecular Mechanisms and Therapeutic Implications for Cell Cycle Arrest

In vitro Evaluation of Crude Extracts and Isolated Compounds from Goniothalamus rongklanus and Goniothalamus latestigma for Bioactive Properties

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