Cytotoxic, Genotoxic, Mutagenic, and Phytotoxic Effects of the Extracts from Eragrostis plana Nees, 1841 (Poaceae), Grown in a Coal-Contaminated Region

Artico, Leonardo Luís; Kömmling, Gizele; Clarindo, Wellington Ronildo; Menezes, Ana Paula Simões

doi:10.1007/s11270-020-4457-6

Cited by 4 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Artico et al [ 62 ] evaluated the cytotoxic, genotoxic, and mutagenic potential of two extracts of E. plana in the experimental model of Allium cepa . The extract used as a positive control (PC) was obtained from E. plana collected in a region of charcoal-contaminated soil, and the other (negative control) obtained from E. plana was collected in a region with a low probability of contamination.…”

Section: Resultsmentioning

confidence: 99%

Phytochemistry Profile, Antimicrobial and Antitumor Potential of the Methanolic Extract of Tabernaemontana catharinensis A DC and Eragrostis plana NEES

da Rosa,

Stopiglia,

Machado

et al. 2024

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Natural compounds that have the potential to act as antimicrobials and antitumors are a constant search in the field of pharmacotherapy. Eragrostis plana NEES (Poaceae) is a grass with high allelopathic potential. Allelopathy is associated with compounds generated in the primary and secondary metabolism of the plant, which act to protect it from phytopathogens. Tabernaemontana catharinensis A DC (Apocynaceae), a tree in which its leaves and bark are used for the preparation of extracts and infusions that have anti-inflammatory and antinociceptive effects, is attributed to its phytochemical constitution. The objective of this study was to elucidate the phytochemical constitution, the antibacterial potential, the toxicity against immune system cells, hemolytic potential, and antitumor effect of methanolic extracts of E. plana and T. catharinensis. The phytochemical investigation was carried out using the UHPLC-QTOF MS equipment. The antibacterial activity was tested using the broth microdilution plate assay, against Gram-negative and Gram-positive strains, and cytotoxicity assays were performed on human peripheral blood mononuclear cells (PBMC) and in vitro hemolysis. Antitumor activity was performed against the colon cancer cell line (CT26). Results were expressed as mean and standard deviation and analyzed by ANOVA. p<0.05 was considered significant. More than 19 possible phytochemical constituents were identified for each plant, with emphasis on phenolic compounds (acids: vanillic, caffeic, and quinic) and alkaloids (alstovenine, rhyncophylline, amezepine, voacangine, and coronaridine). Both extracts showed antibacterial activity at concentrations below 500 µg/mL and were able to decrease the viability of CT26 at concentrations below 2000 µg/mL, without showing cytotoxic effect on PBMCs and in vitro hemolysis at the highest concentration tested. This is the first report of the activity of E. plana and T. catharinensis extracts against colon cancer cell line (CT26). Studies should be carried out to verify possible molecular targets involved in the antitumor effect in vivo.

show abstract

Section: Resultsmentioning

confidence: 99%

Phytochemistry Profile, Antimicrobial and Antitumor Potential of the Methanolic Extract of Tabernaemontana catharinensis A DC and Eragrostis plana NEES

da Rosa,

Stopiglia,

Machado

et al. 2024

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…At this time, we believe there are no research reports on the allelopathic effect of teff on different weed species. Most reports have focused on the allelopathic effect of certain plant species on teff [19,20,[35][36][37][38][39][40][41][42][43]. For example, leaf extracts from different eucalyptus species and Parthenium hysterophorus had an effect on the germination and early growth of teff [19,20].…”

Section: Discussionmentioning

confidence: 99%

Allelopathic Potential of Teff Varieties and Effect on Weed Growth

et al. 2020

View full text Add to dashboard Cite

Allelopathic potential of 10 teff varieties was assessed in laboratory experimentation (conducted in NIBIO, Norway), and determined with an agar-based bioassay using ryegrass and radish as model weeds. Field experiments were conducted in Tigray, Ethiopia during 2015 and 2016 to identify the most important agronomic traits of teff contributing to its weed competitive ability. A split plot design with three blocks was used considering hand weeding as the main plot and varieties as the subplot. Randomized complete block design (RCBD) with four blocks was used in the laboratory experiment. The highest potential allelopathic activity (PAA) and specific potential allelopathic activity (SPAA) were recorded from a local landrace with an average PAA value of 11.77% and SPAA value of 1.21%/mg respectively, when ryegrass was used as the model weed. ‘Boset’ had the highest average PAA value of 16.25% and an SPAA value of 1.53%/mg, when using radish as the model weed. The lowest PAA and SPAA values were recorded from ‘DZ-Cr-387′ when using ryegrass and radish as model weeds. Days to emergence, height, tiller no./plant, biomass yield, and PAA of the crop significantly contributed to the variance of the weed biomass, cover, and density. Hence, they were the most important agronomic traits enhancing the competitive ability of teff.

show abstract

Environmental damage caused by coal combustion residue disposal: A critical review of risk assessment methodologies

Petrović

Fiket

2022

Chemosphere

View full text Add to dashboard Cite

Cytotoxic, Genotoxic, Mutagenic, and Phytotoxic Effects of the Extracts from Eragrostis plana Nees, 1841 (Poaceae), Grown in a Coal-Contaminated Region

Cited by 4 publications

References 16 publications

Phytochemistry Profile, Antimicrobial and Antitumor Potential of the Methanolic Extract of Tabernaemontana catharinensis A DC and Eragrostis plana NEES

Phytochemistry Profile, Antimicrobial and Antitumor Potential of the Methanolic Extract of Tabernaemontana catharinensis A DC and Eragrostis plana NEES

Allelopathic Potential of Teff Varieties and Effect on Weed Growth

Environmental damage caused by coal combustion residue disposal: A critical review of risk assessment methodologies

Contact Info

Product

Resources

About