2022
DOI: 10.21203/rs.3.rs-1769455/v2
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Cytotoxic flavokawain B inhibits the growth and metastasis of hepatocellular carcinoma through the suppression of UCK2-mediated downregulation of the STAT3/Hif-1α/VEGF signalling pathway

Abstract: Hepatocellular carcinoma (HCC) is currently the third most common cancer-related death worldwide. HCC is associated with a high mortality rate due to early recurrence and its distant metastasis to the nearby organs. Current treatment options include surgical removal and transplantation as well as chemotherapy, which remains a major challenge to patient treatment. Flavokawain B (FKB) is a natural bioactive molecule capable of providing effective therapy against this life-threatening disease. This study investig… Show more

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