Cytotoxic Evaluation and Determination of Organic and Inorganic Eluates from Restorative Materials

Roussou, Konstantina; Nikolaidis, Alexandros K.; Ziouti, F; Arhakis, Aristidis; Arapostathis, Konstantinos; Koulaouzidou, Elisabeth A.

doi:10.3390/molecules26164912

Cited by 6 publications

(3 citation statements)

References 104 publications

(149 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many papers have investigated the cytotoxicity reactions and biocompatibility of RBCs due to monomer elution [ 31 , 32 , 33 ]. The monomers and additive components have shown estrogenic, teratogenic, mutagenic, and genotoxic effects [ 34 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Modeling Liquids and Resin-Based Dental Composite Materials—A Scoping Review

et al. 2022

View full text Add to dashboard Cite

Several lubricant materials can be used to model resin-based composites (RBCs) during restorative procedures. Clinically, instruments or brushes are wet with bonding agents (BAs) or modeling liquids (MLs) for sculpturing purposes. However, a knowledge gap exists on their effects on the mechanical properties of RBCs, requiring greater insight. Five databases were searched, including 295 in vitro studies on the use of lubricant materials for modeling RBCs during restorative procedures. Only articles in the English language were included, with no limits on the publication date. The last piece of research was dated 24 March 2022. In total, 16 studies were included in the review process, together with a paper retrieved after screening references. A total of 17 BAs and 7 MLs were investigated. Tensile (n = 5), flexural strength (n = 2), water sorption (n = 2), color stability (n = 8) and translucency (n = 3), micro-hardness (n = 4), roughness (n = 3), degree of conversion (n = 3), and monomer elution (n = 2) tests were carried out. In general, a maximum of 24 h of artificial storage was performed (n = 13), while four papers tested the specimens immediately. The present review identifies the possibilities and limitations of modeling lubricants used during restorative procedures on the mechanical, surface, and optical properties of RBCs. Clinicians should be aware that sculpturing RBCs with modeling resins might influence the composite surface properties in a way that is material-dependent.

show abstract

Section: Discussionmentioning

confidence: 99%

Modeling Liquids and Resin-Based Dental Composite Materials—A Scoping Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The release of Si from glass ionomer cements has also been reported 49 but no correlation has been made with any toxic effects of this release. Interestingly, the synergistic effects of Sr and Si have been reported [50][51][52][53] and this requires further investigation for the further development of Si-based silicate cements.…”

Section: Elemental Migration Assessmentmentioning

confidence: 99%

Can strontium replace calcium in bioactive materials for dental applications?

Pelepenko

Marciano

Francati

et al. 2022

J Biomedical Materials Res

View full text Add to dashboard Cite

The substitution of calcium with strontium in bioactive materials has been promising but there has been some concern over the material instability and possible toxicity. The aim of this research was the synthesis and characterization of calcium and strontium substituted bioactive materials and assessment of interactions with local tissues and peripheral elemental migration in an animal model. A bioactive glass, hydroxyapatite and hydraulic calcium silicate with 50% or 100% calcium substitution with strontium were developed and the set materials were characterized immediately after setting and after 30 and 180-days in solution.Following subcutaneous implantation, the local (tissue histology, elemental migration) and systemic effects (elemental deposition after organ digestion) were assessed. The strontium-replaced silicate cements resulted in the synthesis of partially substituted phases and strontium leaching at all-time points. The strontium silicate implanted in the animal model could not be retrieved in over half of the specimens showing the high rate of material digestion. Tissue histology showed that all materials caused inflammation after 30 days of implantation however this subsided and angiogenesis occurred after 180 days. Strontium was not detected in the local tissues or the peripheral organs while all calcium containing materials caused calcium deposition in the kidneys. The tricalcium silicate caused elemental migration of calcium and silicon in the local tissues shown by the elemental mapping but no deposition of calcium was identified in the peripheral organs verified by the assessment of the digested tissues. Strontium can substitute calcium in bioactive materials without adverse local or systemic effects.

show abstract

“…Resin composite direct restorations constitute the primary modality in restorative dentistry, which are supported by well-documented studies investigating the mechanical properties [ 7 , 8 ], chemical properties [ 9 ] and biological properties of this material [ 10 ]. Nevertheless, the placement of large direct resin composite restorations presents challenges in terms of technique sensitivity and is associated with drawbacks such as dentin sensitivity [ 11 ] and potential microcracks in the enamel at the cusp base [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Fracture Resistance of Class II MOD Cavities Restored by Direct and Indirect Techniques and Different Materials Combination

Tsertsidou,

Mourouzis,

Dionysopoulos

et al. 2023

Polymers

View full text Add to dashboard Cite

This study aimed to evaluate the fracture resistance of class II MOD cavities restored using different techniques and materials. Sixty extracted maxillary molars were selected and standardized class II MOD cavities were prepared using a custom-made paralleling device. The specimens were divided into four groups based on the restoration technique used: Group 1 (direct resin composite), Group 2 (short-fiber-reinforced composite resin), Group 3 (composite polyethylene fiber reinforcement), and Group 4 (CAD/CAM resin inlays). Fracture resistance was assessed for each group after thermocycling aging for 10,000 cycles. The mode of fracture was assigned to five types using Burke’s classification. To compare the fracture force among the tested materials, a paired sample t-test was performed. The significance level for each test was set at p < 0.05. Significant differences in fracture resistance were observed among the different restoration techniques. CAD/CAM inlays (2166 ± 615 N), short-fiber-reinforced composite resin (2471 ± 761 N), and composite polyethylene fiber reinforcement (1923 ± 492 N) showed superior fracture resistance compared to the group restored with direct resin composite (1242 ± 436 N). The conventional resin composite group exhibited the lowest mean fracture resistance. The choice of restoration material plays a critical role in the clinical survival of large MOD cavities. CAD/CAM inlays and fiber-reinforced composites offer improved fracture resistance, which is essential for long-term success in extensive restorations.

show abstract

Cytotoxic Evaluation and Determination of Organic and Inorganic Eluates from Restorative Materials

Cited by 6 publications

References 104 publications

Modeling Liquids and Resin-Based Dental Composite Materials—A Scoping Review

Modeling Liquids and Resin-Based Dental Composite Materials—A Scoping Review

Can strontium replace calcium in bioactive materials for dental applications?

Fracture Resistance of Class II MOD Cavities Restored by Direct and Indirect Techniques and Different Materials Combination

Contact Info

Product

Resources

About