Cytotoxic Effects of Tenebrio molitor Larval Extracts against Hepatocellular Carcinoma

이지은,; 이안중,; 조다은,; 조주형,; 윤금주,; 윤은영,; 황재삼,; 전미라,; 강병헌,

doi:10.3746/jkfn.2015.44.2.200

Cited by 17 publications

(5 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In terms of biological activity, recent studies have reported that T. molitor larvae may protect against hepatocellular carcinoma (Lee et al 2015), inhibit beta-secretase 1 enzyme activity related to accumulation of beta-amyloid (Youn et al 2014), and alleviate obesity in vitro and in vivo (Seo et al 2017). However, the antioxidant activity of T. molitor larvae has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Effects of processing methods on nutritional composition and antioxidant activity of mealworm (Tenebrio molitor) larvae

Baek

Kim

Kwon

et al. 2019

Entomological Research

Self Cite

View full text Add to dashboard Cite

We examined the effects of different processing methods on the nutritional composition and antioxidant activity of mealworms. After processing with nine methods, we calculated the contents of protein, fat, ash, carbohydrate, minerals (P, Ca, K, Fe, Na), vitamin B group (B1, B2, B3), moisture, and calories. When processed by freeze drying among freeze drying, hot air drying, oven broiling, roasting, pan frying, deep frying, boiling, steaming, and microwaving, the contents of protein, some minerals, and vitamins were the highest. The content of total minerals was lowest after deep frying, and those of vitamin B1 and B3 were the lowest after microwaving. Antioxidant activity was then evaluated using DPPH and ABTS radical scavenging assays. DPPH assays showed that microwaving, freeze drying, deep frying, steaming, boiling, and oven broiling of mealworms yielded scavenging activities of 20.9–29.0% at 2,000 μg/mL, which was similar to the activity level (22.7–33.2%) of 40–60 μM tocopherol. ABTS assays confirmed that only freeze‐dried mealworms at 2,000 μg/mL exhibited higher activity than 10 μM tocopherol. Interestingly, similar trends were found for antioxidant activity levels and total phenolic contents in mealworms.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of processing methods on nutritional composition and antioxidant activity of mealworm (Tenebrio molitor) larvae

Baek

Kim

Kwon

et al. 2019

Entomological Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…One of the most popular edible insect species worldwide is mealworm larva (MWL) (Tenebrio molitor) belonging to order Coleoptera and family Tenebrionidae. MWL extract showed cytotoxic activity against prostate cancer (PC-3 and 22Rv1), cervical carcinoma (HeLa), hepato-carcinoma (PLC/PRF5, HepG2, Hep3B, and SK-HEP-1), colon (HCT116), lung (NCI-H460), breast cancer (MDA-MB231), and ovarian cancer (SKOV3) cell lines by reducing proliferation and inducing apoptosis, necrosis and autophagy (Lee et al, 2015). Aqueous extract of MWL and Anoplophora chinensis showed antiinflammatory activity against the colorectal adenocarcinoma cell line, Caco-2, and human hepatocellular carcinoma cell line, HepG2, and induced apoptosis by upregulating death receptor and caspase 3 expression (Ding et al, 2021).…”

Section: Insect Extractsmentioning

confidence: 99%

Revisiting edible insects as sources of therapeutics and drug delivery systems for cancer therapy

Sinha,

Choudhury

2024

Front. Pharmacol.

View full text Add to dashboard Cite

Cancer has been medicine’s most formidable foe for long, and the rising incidence of the disease globally has made effective cancer therapy a significant challenge. Drug discovery is targeted at identifying efficacious compounds with minimal side effects and developments in nanotechnology and immunotherapy have shown promise in the fight against this complicated illness. Since ancient times, insects and insect-derived products have played a significant role in traditional medicine across several communities worldwide. The aim of this study was to inspect the traditional use of edible insects in various cultures and to explore their modern use in cancer therapy. Edible insects are sources of nutrients and a variety of beneficial substances with anticancer and immunomodulatory potential. Recently, insect derived bioactive-components have also been used as nanoparticles either in combination with chemotherapeutics or as a nano-cargo for the enhanced delivery of chemotherapeutic drugs due to their high biocompatibility, low bio-toxicity, and their antioxidant and anticancer effects. The crude extracts of different edible insects and their active components such as sericin, cecropin, solenopsin, melittin, antimicrobial peptides and fibroin produce anti-cancer and immunomodulatory effects by various mechanisms which have been discussed in this review.

show abstract

“…As mentioned above, it is believed that MTB possess many benefits for human health including the prevention of cardiovascular diseases, iron deficiency anemia, among others (Zhang, 2013). Previous studies have shown that MWL extracts possess antiproliferative effects against hepatocellular carcinoma cells (Lee et al., 2015). However, the effect of such extracts on other cancer cell lines has not yet been studied.…”

Section: Introductionmentioning

confidence: 98%

Antiproliferative effects of mealworm larvae ( Tenebrio molitor ) aqueous extract on human colorectal adenocarcinoma (Caco‐2) and hepatocellular carcinoma (HepG2) cancer cell lines

Ding

Shi

et al. 2021

J Food Biochem

View full text Add to dashboard Cite

Recently, insects have aroused the interest of researchers as potential therapeutic resources against malignant diseases such as cancer. In this study, the effects of aqueous extracts from mysore thorn borer (MTB) (Anoplophora chinensis) and mealworm larvae (MWL) (Tenebrio molitor) against cancer cells were investigated. MWL aqueous extract showed higher antiproliferative effects against Caco‐2 and HepG2 cells compared to MTB. The IC50 (48 hr) of MWL aqueous extract were 11.44 and 20 mg/ml for Caco‐2 and HepG2 respectively. Flow cytometry analysis showed that MWL aqueous extract induced apoptosis in Caco‐2 and HepG2 increasing from 2.06% to 74.34% and from 0.04% to 42.14% after 24 hr respectively. Caspase activity assay showed that apoptosis was mediated via death receptor pathway mediated by caspase‐8 and ‐9 followed by the activation of caspase‐3; caspase‐3 may have induced DNA damage and cell death. These effects may be correlated to its free amino acids. The results of this study demonstrate the potentials of MWL in the development of natural anticancer therapeutics in the future. Practical applications Natural nutraceuticals from insects might be useful for the treatment and prevention of cancers such as colorectal and liver cancer. In recent years, edible insects have caught the attention of researchers, because of their potential as an alternative source of food and nutraceuticals. The results of our study showed that MWL extract might provide important anticancer compounds against colon and liver cancer.

show abstract

Cytotoxic Effects of Tenebrio molitor Larval Extracts against Hepatocellular Carcinoma

Cited by 17 publications

References 38 publications

Effects of processing methods on nutritional composition and antioxidant activity of mealworm (Tenebrio molitor) larvae

Effects of processing methods on nutritional composition and antioxidant activity of mealworm (Tenebrio molitor) larvae

Revisiting edible insects as sources of therapeutics and drug delivery systems for cancer therapy

Antiproliferative effects of mealworm larvae ( Tenebrio molitor ) aqueous extract on human colorectal adenocarcinoma (Caco‐2) and hepatocellular carcinoma (HepG2) cancer cell lines

Contact Info

Product

Resources

About