Cytotoxic effects of peanut phenolic compounds possessing histone deacetylase inhibitory activity on human colon cancer cell lines

Saenglee, Somprasong; Jogloy, Sanun; Patanothai, A.; Senawong, Thanaset

doi:10.3906/biy-1601-23

Cited by 18 publications

(19 citation statements)

References 45 publications

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“…The differences were particularly expressed in the ferulic acid that was the most abundant phenolic acid in Puno extracts (78% of the total acids) but not identified in Titicaca extract. The results of other authors confirmed a significant cytotoxic effect of ferulic acid against colon cancer cells (Kumnerdkhonkaen et al, 2018; Saenglee, Jogloy, Patanothai, & Senawong, 2016). Furthermore, Zhang et al (2016) based on their research in vitro and in vivo models indicated that the ferulic acid has antitumor potential that could be used as a therapeutic agent against breast cancer.…”

Section: Resultssupporting

confidence: 52%

Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars

et al. 2020

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Background and objectives Quinoa is considered to be a “natural functional food” due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health‐promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time‐dependent effects were more expressed in Puno extracts. Conclusions The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. Significance and novelty The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT‐116, as well as the presence of 7 new phenolic and flavonoid compounds.

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Section: Resultssupporting

confidence: 52%

Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars

et al. 2020

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“…In addition, the cell cycle arrest induced by TFs was compared to phenolic compounds p -coumaric acid and resveratrol. According to the results conducted by Saenglee et al, 1000 μM p -coumaric acid could merely enhance the G0/G1-phase cell population by 9.60% in colon cancer cell line HCT-116 cells and 50 μM resveratrol enhanced the G2/M-phase cell population by 5.50% in colon cancer cell line HT-29 cells, which were much lower than TFs. In conclusion, these results indicated that TFs could induce cell cycle arrest to efficiently kill cancer cells.…”

Section: Resultsmentioning

confidence: 93%

Structure–Activity Relationship Analysis on Antioxidant and Anticancer Actions of Theaflavins on Human Colon Cancer Cells

Tan¹,

Peng

Huang³

et al. 2018

J. Agric. Food Chem.

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The roles of natural products as effective cancer prevention and therapeutic agents have been documented by various studies in recent years, but the action mechanisms and structure−activity relationship need more elucidation. The present study showed that theaflavins (theaflavin and its derivatives, TFs) from black tea caused an inhibitory effect on the proliferation of human colon adenocarcinoma cancer SW480 cells and human colon cancer SW620 cells [half maximal inhibitory concentration (IC 50 ) < 32.0 μM] by the induction of cell cycle arrest but exerted lower toxicity against normal cells with a high safety index (1.89−6.26). Moreover, TFs triggered a decrease in reactive oxygen species in SW480 cells as a result of their excellent radical-scavenging ability (e.g., the IC 50 value of TF4 to ABTS • + was 1.91 ± 0.21 μM). More importantly, the structure−activity relationship analysis of TFs exhibited that the galloyl group was an important factor to affect these activities. Taken together, we revealed that the TFs could act as substitutes for natural antioxidants and promising anticancer agents with beneficial influence on human health and then anticipated that this study may provide useful information on the development of therapeutic natural products.

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“…Sinapinic acid inhibited the growth of several human cancer cells (HT29, HCT116, HeLa and Jurkat cells; IC 50 values = 1.6, 2.1, 0.9 and 2.8 mM, respectively, for 72 h exposure) [ 19 ]. Ferulic acid has been shown to inhibit the growth of several human cancer cells (HT29, HCT116, MCF7 and HeLa cells; IC 50 values = 2.2, 2.1, 4.0 and 0.9 mM, respectively, for 72 h exposure) by apoptosis induction [ 34 , 35 ]. Accordingly, gallic, vanillic, syringic, p -coumaric, ferulic and sinapinic acids may, at least in part, contribute to antiproliferative activity of the extracts from the powder mix of H. cordata fermented broth and P. emblica fruit especially those with relatively high amounts in the extracts ( p -coumaric and ferulic acids).…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative activities and phenolic acid content of water and ethanolic extracts of the powdered formula of Houttuynia cordata Thunb. fermented broth and Phyllanthus emblica Linn. fruit

Kumnerdkhonkaen

Saenglee

Asgar

et al. 2018

BMC Complement Altern Med

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BackgroundHouttuynia cordata Thunb. and Phyllanthus emblica Linn. are native plants with medicinal and nutritive significance in Asia. The present study was aimed at evaluating antiproliferative effects on human cancer cell lines and identifying the phenolic acid composition of water and ethanolic extracts of the powdered formula of H. cordata fermented broth and P. emblica fruit.MethodsAnticancer activity of the extracts was evaluated against HeLa, HT29, HCT116, MCF7 and Jurkat cells using an MTT assay and flow cytometric analysis of apoptosis induction and cell cycle arrest. Reverse phase HPLC was exploited for identification and quantification of some phenolic acids.ResultsMTT assay showed that both water and ethanolic extracts significantly decreased the viability of cancer cells in a dose- and time-dependent fashion. Based on the IC50 values, ethanolic extract (IC50 values = 0.12–0.65 mg/mL) was more cytotoxic than water extract (IC50 values = 0.22–0.85 mg/mL) and Jurkat cells were the most sensitive to both extracts (IC50 values = 0.12–0.69 mg/mL). The underlying mechanism for antiproliferative activity was apoptosis induction, especially in HT29, HCT116, MCF7 and Jurkat cells. HT29 cells were the most sensitive to extract-induced apoptosis. Ethanolic extract was more effective at inducing apoptosis than water extract. Moreover, cell cycle arrest was found to be another mechanism behind growth inhibition in Jurkat and HCT116 cells. However, these extracts were relatively less toxic to non-cancer Vero cells. HPLC analysis demonstrated that the powder mix extracts contained seven identified phenolic acids namely gallic, p-hydroxybenzoic, vanillic, syringic, p-coumaric, ferulic and sinapinic acids, where p-coumaric acid was detected in the highest concentration followed by ferulic acid.ConclusionOverall, the results of this study suggest the powdered formula of H. cordata fermented broth and P. emblica fruit as an alternative medicine for cancer prevention and treatment.

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Cytotoxic effects of peanut phenolic compounds possessing histone deacetylase inhibitory activity on human colon cancer cell lines

Cited by 18 publications

References 45 publications

Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars

Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars

Structure–Activity Relationship Analysis on Antioxidant and Anticancer Actions of Theaflavins on Human Colon Cancer Cells

Antiproliferative activities and phenolic acid content of water and ethanolic extracts of the powdered formula of Houttuynia cordata Thunb. fermented broth and Phyllanthus emblica Linn. fruit

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