Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines

Hadizadeh, Shahram; Najafzadeh, Nowruz; Mazani, Mohammad; Amani, Mojtaba; Mansouri‐Torshizi, Hassan; Niapour, Ali

doi:10.1155/2014/813457

Cited by 28 publications

(13 citation statements)

References 42 publications

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“…The obtained IC 50 values are 1.5, 1.8, 3.4 and 6.1 mM for 1 , 2 , Met and IDA, respectively. These values of the ligands and their Ni (II) complexes were compared to cisplatin and were found to be higher as compared to those achieved for cisplatin (IC 50 = 0.2 mM) . The trend of cytotoxicity was found to be complex 1 < complex 2 < Met < IDA.…”

Section: Resultsmentioning

confidence: 99%

Metformin Containing Nickel (II) Complexes: Synthesis, Structural Characterization, Binding and Kinetic Interactions with BSA, Antibacterial and in‐vitro Cytotoxicity Studies

El-Shami

Ramadan

Ibrahim

et al. 2020

Applied Organom Chemis

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In quest of antimicrobial and anticancer agents, metformin containing Ni (II) complexes, [Ni (Met)2]Cl·OH (1) and [Ni (Met)(IDA)] (2) {Met: metformin, IDA: iminodiacetic acid} were synthesized and X‐ray structure of 1 is four‐coordinate square planar geometry. Bovine serum albumin (BSA) interaction and binding studies to Met, IDA and their Ni (II) complexes were investigated and showed a strong interaction. A static quenching process was proposed at low concentrations of compounds whereas, combined quenching process was observed for 1 and 2 at higher concentrations. Kinetic stability, affinity and association constants of compounds‐BSA were studied using stopped‐flow technique and a mechanism was proposed: a fast and reversible step of BSA binding including complex formation and dissociation was proposed; for the second step, a reversible reaction was observed for 1 and 2 whereas, an irreversible reaction with Met and IDA was observed indicating that coordination with nickel ions change the interaction mechanism. Additionally, the antibacterial investigation against both Gram‐positive and Gram‐negative bacteria showed that all compounds exhibited significant activities. They also show cytotoxicity against HepG2 human liver cancer cell but the half maximal inhibitory concentration (IC50) values obtained for the cell lines were higher in comparison with cisplatin. Although Met‐BSA and IDA‐BSA are kinetically more stable than that of 1‐BSA and 2‐BSA, 1‐BSA and 2‐BSA showed better antibacterial and cytotoxic activities which is in agreement with the binding constants.

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Section: Resultsmentioning

confidence: 99%

Metformin Containing Nickel (II) Complexes: Synthesis, Structural Characterization, Binding and Kinetic Interactions with BSA, Antibacterial and in‐vitro Cytotoxicity Studies

El-Shami

Ramadan

Ibrahim

et al. 2020

Applied Organom Chemis

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“…The metal chelate interacts with DNA, likely in a mode that includes electrostatic or hydrophobic interaction. As expressed previously, the CuL complex has two replaceable water molecules coordinated to copper(II) ion in solution, which might be substituted with DNA double helix molecules in the solution [35,41,45,58,59]. Likewise, because of the replacement reaction of water ligand molecules from the CuL complex in solution, the explored metal chelates would have a flat part in the middle.…”

Section: Gel Electrophoresismentioning

confidence: 88%

Non-Linear Optical Property and Biological Assays of Therapeutic Potentials Under In Vitro Conditions of Pd(II), Ag(I) and Cu(II) Complexes of 5-Diethyl amino-2-({2-[(2-hydroxy-Benzylidene)-amino]-phenylimino}-methyl)-phenol

et al. 2020

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Herein, we report facile procedures for synthesis of a new Schiff base ligand (H2L,5-Diethylamino-2-({2-[(2-hydroxy-benzylidene)-amino]-phenylimino}-methyl)-phenol) and its Ag(I), Pd(II) and Cu(II) complexes. The structure of the H2L ligand as well as its metal complexes was deduced based on wide range of analytical, structural and spectroscopic tools, along with theoretical evidence via density functional theory (DFT) calculations. The obtained results indicated that the Schiff base (H2L) ligand acts as a tetradentate N2O2 donor with two azomethine nitrogen’s (N1, N2) and two deprotonated phenolic oxygens (O1, O2) atoms. A distorted octahedral structure is assigned to [CuL(OH2)2]·3/2H2O complex and square planar structure for PdL and AgL complexes. The electronic structure and non-linear optical (NLO) property of the prepared compounds were discussed theoretically by the B3LYP/GENECP program. Results revealed that all complexes have non-planner geometries as indicated from the dihedral angles. The charge transfer occurs within the synthesized complexes as indicated from the calculated energy gap between HOMO and LUMO energies. The H2L ligand and its complexes are excellent candidates for NLO materials as implied from their hyperpolarizabilities and polarizabilities values. The biological activities of the prepared complexes against selected microorganisms and cancer cell lines gave good growth inhibitory effect. The biocidal potencies of the ligand and its complexes can be arranged as follows: AgL > CuL > PdL > H2L, as compared to the used standard drugs. The antiproliferative activity of the studied complexes against different carcinoma cell lines such as liver (Hep-G2), breast (MCF-7) and colon (HCT-116) followed the order H2L < AgL< PdL < CuL < vinblastine. Probing the binding interactions of prepared complexes with calf thymus (CT)-DNA using electronic absorption, gel electrophoresis and viscosity measurements revealed strong interaction via intercalation modes, as also evidenced by their molecular docking study.

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“…Among all, tetrazolium (MTT) is one of the most often used, which uses colorimeter to determine cell viability. Cytotoxicity test is done to assess cell viability by a dose response compounds' toxicities [104–106]. Cytotoxicity is usually assessed with MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] assay.…”

Section: Biological Applicationsmentioning

confidence: 99%

Dithiocarbamates: Challenges, Control, and Approaches to Excellent Yield, Characterization, and Their Biological Applications

Odularu

Ajibade

2019

Bioinorganic Chemistry and Applications

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Progresses made in previous researches on syntheses of dithiocarbamates led to increase in further researches. This paper reviews concisely the challenges experienced during the synthesis of dithiocarbamate and mechanisms to overcome them in order to obtain accurate results. Aspects of its precursor’s uses to synthesize adducts, nanoparticles, and nanocomposites are reported. Some common characterization techniques used for the synthesized products were assessed. Biological applications are also reported.

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Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines

Cited by 28 publications

References 42 publications

Metformin Containing Nickel (II) Complexes: Synthesis, Structural Characterization, Binding and Kinetic Interactions with BSA, Antibacterial and in‐vitro Cytotoxicity Studies

Metformin Containing Nickel (II) Complexes: Synthesis, Structural Characterization, Binding and Kinetic Interactions with BSA, Antibacterial and in‐vitro Cytotoxicity Studies

Non-Linear Optical Property and Biological Assays of Therapeutic Potentials Under In Vitro Conditions of Pd(II), Ag(I) and Cu(II) Complexes of 5-Diethyl amino-2-({2-[(2-hydroxy-Benzylidene)-amino]-phenylimino}-methyl)-phenol

Dithiocarbamates: Challenges, Control, and Approaches to Excellent Yield, Characterization, and Their Biological Applications

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