Abstract:In this study, five neolignans were isolated from Saururus cernuus—threo‐dihydroguaiaretic acid (1), threo‐austrobailignan‐6 (2), threo‐austrobailignan‐5 (3), verrucosin (4), and saucernetin (5)—and have their cytotoxic effects evaluated in prostate cancer cell lines (PC3 and DU145). Initially, using an in silico approach, tested compounds were predicted to be absorbed by the gastrointestinal tract, be able to permeate the blood–brain barrier and did not show any alert in PAINS (pan‐assay structures interferen… Show more
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