Cytotoxic effects, alkylating properties and molecular modelling of coumarin derivatives and their phosphonic analogues

Budzisz, Elżbieta

doi:10.1016/s0223-5234(03)00086-2

Cited by 130 publications

(39 citation statements)

References 8 publications

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“…Both coumarin and coumarin derivatives have shown promise as potential inhibitors of cellular proliferation in various carcinoma cell lines. In addition, it has been shown that 4-hydroxycoumarin and 7-hydroxycoumarin inhibited cell proliferation in a gastric carcinoma cell line (Budzisz et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic potential of 7,8-dimethoxycoumarin on cisplatin- and ischemia/reperfusion injury-induced acute renal failure in rats

Muthuraman

Sood

Ramesh³

et al. 2012

Naunyn-Schmiedeberg's Arch Pharmacol

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This study was designed to investigate the role of 7,8-dimethoxycoumarin on cisplatin- and ischemia/reperfusion (I/R)-induced acute renal failure in rats. Acute renal failure was induced in rats by administration of a single dose of cisplatin (CP) (6 mg/kg, intraperitoneally on day 6) and occlusion of the left renal artery for 45 min (I) and opened for the next 24 h (R). The drug samples of 7,8-dimethoxycoumarin (DMC, 50, 75, and 100 mg/kg) and cyclosporin A (50 μM/kg) were administered orally for six consecutive days. Administration of a single dose of cisplatin and I/R event has significantly raised blood urea nitrogen and creatinine, N-acetyl beta-D: -glucosaminidase, and thiobarbituric acid reactive substances but decreased FrNa, creatinine clearance, reduced glutathione (GSH), mitochondrial cytochrome c oxidase, and adenosine triphosphate levels. Further, pretreatment of DMC (50, 75, and 100 mg/kg, p.o., for six consecutive days) has ameliorated the CP- and I/R-induced biochemical and histopathological changes in a dose-dependent manner. Furthermore, 75 and 100 mg/kg of 7,8-dimethoxycoumarin has shown to possess the significant renoprotective effect similar to that of the cyclosporin A-treated group which served as positive control. Based on the results of the present study, it has been concluded that 7,8-dimethoxycoumarin protects the kidney against the CP and I/R injury via antioxidant, anti-inflammatory, and inactivation of mitochondrial permeability transition pore opening.

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Section: Discussionmentioning

confidence: 99%

Therapeutic potential of 7,8-dimethoxycoumarin on cisplatin- and ischemia/reperfusion injury-induced acute renal failure in rats

Muthuraman

Sood

Ramesh³

et al. 2012

Naunyn-Schmiedeberg's Arch Pharmacol

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“…[66][67][68][69] This four co-ordinated Pd(II) complex 117 exists in cis-isomeric form for the ligand L (R = H) and trans-form for L (R = other than H). 67,68 Cytotoxic effects of the diones 115 and several of their Pd(II) complexes have been assessed against two leukemia cell lines HL-60 and NALM-6.…”

Section: Scheme 16mentioning

confidence: 99%

Chemistry of 3-carbonyl-2-methyl-4-oxo-4H-1-benzopyrans

Ghosh¹,

Chakraborty²

2016

Arkivoc

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“…Synthesis and potent antimicrobial activity of some novel phenyl derivatives was reported by Göker et al (2005), while the tested free ligand (H 2 L 1 ) was less inhibitor only up to 50% at the highest concentration (0.4%), but not comparable to the broad-spectrum antifungal drug and this may refer to the absence of phenyl aromatic linkage. Budzisz et al (2003) found a relationship between biological activity and the physicochemical properties of the coumarin. Microbial evaluation of functionalized coumarins was evaluated (Shen et al, 2005).…”

Section: Scanning Electron Microscope (Sem) Investigationmentioning

confidence: 99%

Novel inhibition of some pathogenic fungal and bacterial species by new synthetic phytochemical coumarin derivatives

Geweely

2009

Ann. Microbiol.

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Cytotoxic effects, alkylating properties and molecular modelling of coumarin derivatives and their phosphonic analogues

Cited by 130 publications

References 8 publications

Therapeutic potential of 7,8-dimethoxycoumarin on cisplatin- and ischemia/reperfusion injury-induced acute renal failure in rats

Therapeutic potential of 7,8-dimethoxycoumarin on cisplatin- and ischemia/reperfusion injury-induced acute renal failure in rats

Chemistry of 3-carbonyl-2-methyl-4-oxo-4H-1-benzopyrans

Novel inhibition of some pathogenic fungal and bacterial species by new synthetic phytochemical coumarin derivatives

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