2021
DOI: 10.1007/s00590-021-02907-3
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Abstract: Purpose Soft tissue, bone and joint infections are severe complications in orthopedic and traumatological surgery. Lavanox (0.08% NaOCl) and Irrisept (0.05% chlorhexidine gluconate, CHG) are industrially produced antiseptic solutions commonly used in infection treatment. Regarding this clinical indication, the microbicidal effect is often investigated, but toxicity to osteoblasts has rarely been examined. This is important to decide whether these solutions should be used in septic situations in w… Show more

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“…The ongoing debate as to whether solutions such as betadine are superior to chlorhexidine gluconate-based solutions illustrates the useful adjunct that intra-articular irrigation plays. In choosing which solution is superior, most agree that it should be capable of penetrating the biofilm that is a hallmark of chronic PJI, while remaining minimally-cytotoxic to host tissue that will prove crucial towards the inevitable lengthy healing process [56][57][58][59]. In addition to the contents of the irrigating solution, there has been significant discussion regarding appropriate irrigation pressure and duration.…”
Section: Role Of Intra-articular Irrigationmentioning
confidence: 99%