Cytotoxic effect of hydroalcoholic extract of Cota tinctoria (L.) J.Gay  on AGS and Hep-G2 cancer cell lines

Shamloo, Sharareh; Marandi, Sayeh Jafari; Tajadod, Golnaz; Majd, Ahmad; Rahimi, Roja

doi:10.37360/blacpma.22.21.1.07

Cited by 2 publications

(1 citation statement)

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“…tinctoria were mentioned [ 36 ]. Cytotoxic activity of ethanol extract of C. tinctoria flowers was investigated [ 37 ]. In another study, phenolic constituents, cytotoxic activity, and dyeing properties for the ethanol and aqueous extracts of stem, flower, and root of the plant were studied [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and lipase inhibition of essential oil and solvent extracts of Cota tinctoria var. tinctoria and characterization of the essential oil

ERİK¹,

BOZDAL²,

ŞENER³

et al. 2022

Turkish Journal of Chemistry

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The essential oil (EO) of Cota tinctoria var. tinctoria was analyzed using GC-FID / MS. A total of 51 compounds were determined from this taxon, accounting for 99.79% in hydrodistillation. Monoterpenes were the primary chemical class for the volatile organic compounds in the EO (36.1%, 13 compounds). Borneol (18.1%), camphor (14.9%), and β -pinene (11.3%) were the major components in the EO of C. tinctoria var. tinctoria . The antimicrobial activities of EO and n- hexane, acetonitrile, methanol, and water solvent extracts of the taxon were screened in vitro against ten microorganisms. The EO yielded the best activity (15 mm, 372.5 MIC, 59600 μg/μL) against Mycobacterium smegmatis . The acetonitrile extract was the most active against the Staphylococcus aureus and Bacillus cereus with 274 μg/mL MIC value. IC 50 values for the lipase enzyme inhibitory activity of EO and solvent extracts ( n- hexane, acetonitrile, methanol, and water) were found to be 59.80 ± 4.3285 μg/mL 68.28 ± 3.1215 μg/mL, 52.60 ± 3.7526 μg/mL, 48.73 ± 2.8265 μg/mL, and 99.50 ± 5.5678 μg/mL, respectively.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial and lipase inhibition of essential oil and solvent extracts of Cota tinctoria var. tinctoria and characterization of the essential oil

ERİK¹,

BOZDAL²,

ŞENER³

et al. 2022

Turkish Journal of Chemistry

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Elaboration and Validation of a Spectrophotometric Technique for Estimation of the Total Flavonoids in Anthemis Tinctoria Herb

Z.V.

E.A.

P.S.

2022

Mediko-farmacevtičeskij žurnal "Pulʹs"

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The aim of this work is development and validation of a spectrophotometric technique for quantification of total flavonoids in terms of rutin in potentially medicinal plant Anthemis tinctoria herb. According to the literature, Anthemis tinctoria is used in folk medicine as a hepatoprotective, hemostatic and means, and its extracts in the experiment exhibit antimicrobial, cytostatic and antioxidant activities. In this work, we used sample of Anthemis tinctoria herb harvested in the summer of 2021 during the period of mass flowering in vicinity of Perm city (valley of the Vasilievka river, Adishchevo railway station). The raw materials were dried at room temperature, with sufficient ventilation, without direct exposure to sunlight, stored separately from other types of raw materials. According to the experiments the optimal conditions for determining of total flavonoids: grinding the raw material to a size passing through a sieve with a diameter of 1 mm, the optimal concentration of ethyl alcohol extractant is 50%, the analytical wavelength is 410 nm, the extraction time in a boiling water bath is 45 minutes, the ratio of extraction and complexing agent - 2% alcohol solution of aluminum chloride - 2:5. The technique was validated in accordance with the requirements of State Pharmacopeia of Russia 14th edition, the relative error of determination with a reliable probability of 95% was 4.00%. The technique can be used in further work to conduct studies of biological activity.

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Cytotoxic effect of hydroalcoholic extract of Cota tinctoria (L.) J.Gay on AGS and Hep-G2 cancer cell lines

Cited by 2 publications

References 51 publications

Antimicrobial and lipase inhibition of essential oil and solvent extracts of Cota tinctoria var. tinctoria and characterization of the essential oil

Antimicrobial and lipase inhibition of essential oil and solvent extracts of Cota tinctoria var. tinctoria and characterization of the essential oil

Elaboration and Validation of a Spectrophotometric Technique for Estimation of the Total Flavonoids in Anthemis Tinctoria Herb

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