Cytotoxic effect of dihydroquercetin and its derivatives in liposomal form and in the form of fat nanoscale emulsions

Фадеев, Р. С.; Kaptsov, Vladimir; Uminsky, A. A.; Акатов, В. С.

doi:10.1134/s1990747811010053

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Habtemariam et al [53] found that eriodictyol with 3 ,4 -OH showed the strongest protective effect on L-929 cells from tumor necrosis factor (TNF)-induced cell death, while hesperidin (with 3'-OH but without 4'-OH) had no protective effect. It indicated that the flavones with 3',4'-OH had strong antioxidant activity, like dihydroquercetin and quercetin (compounds 1 and 3) [54][55][56][57]. Dihydroquercetin (compound 1) as well-known antioxidants protect DNA from oxidative damage and against oxidative stress by stimulating the expression of HO-1 and NQO1 through the Nrf2-dependent antioxidant pathway [58].…”

Section: The Structural Features and The Antioxidant And Anti-prolifementioning

confidence: 99%

Antioxidant and Anti-Proliferative Properties of Hagenia abyssinica Roots and Their Potentially Active Components

et al. 2020

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Hagenia abyssinica (Bruce) J. F. Gmel. is a multipurpose dioecious tree that has been used to treat various ailments, for example, the flowers of H. abyssinica have been widely used as a tea to treat intestinal parasites by local residents and the roots of H. abyssinica could also be used for anticancer purposes. Antioxidant activity could be one of the most important pathways to suppress cancer and there is hardly any information available on the specific chemical components corresponding to the bioactivities of H. abyssinica to date. The present study intended to screen and evaluate the antioxidant and anti-proliferative properties of five different fractions from H. abyssinica along with their corresponding total flavonoid and phenolic contents and then further identify those compounds with the most potent antioxidant and anti-proliferative activities using high performance liquid chromatography (HPLC) coupled to mass spectrometry (MS) and nuclear magnetic resonance (NMR). The total flavonoid and phenolic content assays showed that the ethyl acetate (EA) fraction of H. abyssinica had higher flavonoid and phenolic levels than the other four fractions. Furthermore, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) superoxide radical scavenging abilities, total antioxidant capacity (TAC) assay with 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS), and ferric-reducing antioxidant power (FRAP) were measured to evaluate the antioxidant activities of the five fractions and some pure compounds isolated from the EA fraction, which displayed higher antioxidant properties than that of the other fractions. Caffeic acid from the EA fraction showed even stronger DPPH scavenging ability (IC50 7.858 ± 0.31 µg/mL) than that of Vc (IC50 8.27 ± 0.11 µg/mL) as the positive control. The anti-proliferative properties of four fractions and the ethanol extract were evaluated by the 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay and the EA fraction exhibited higher anti-proliferative activities against three cancer cell lines than that of the other fractions. Additionally, the compounds with good antioxidant activity from the EA fraction of H. abyssinica were screened and identified using LC-MS and NMR and were also found to possess good anti-proliferative activity. In the MTT assay, the quercetin showed the strongest dose-dependent anti-proliferative activities to colon cancer cells (HT-29) and liver cancer cells (HepG2) among all of the compounds isolated. This study provided valuable information on the synergistic antioxidant and anti-proliferative properties of H. abyssinica.

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Section: The Structural Features and The Antioxidant And Anti-prolifementioning

confidence: 99%

Antioxidant and Anti-Proliferative Properties of Hagenia abyssinica Roots and Their Potentially Active Components

et al. 2020

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Unveiling the therapeutic potential of Taxifolin in Cancer: From molecular mechanisms to immune modulation and synergistic combinations

Sarg,

Hersi,

Zaher

et al. 2024

Phytomedicine

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Solubility Enhancement of Dihydroquercetin via “Green” Phase Modification

Terekhov

Ilyasov

Beloborodov

et al. 2022

IJMS

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Dihydroquercetin (DHQ) is a promising antioxidant for medical applications. The poor water solubility of this flavanonol at ambient conditions inhibits its implementation in clinical practice as an injectable dosage form. Thus, increasing water solubility is a critical step toward solving this problem. Herein we attempted to deal with this problem via DHQ phase modification while at the same time adhering to the principles of green chemistry as much as possible. Lyophilization is an appropriate method to achieve phase modification in an environment-friendly way. This method was employed to generate new phase modifications of DHQ that were then characterized. Mixtures of water with ethanol or acetonitrile were used as solvents for the preparation of the lyophilizates, DHQE, and DHQA, respectively. The results of dissolution testing of the obtained DHQE and DHQA demonstrated that the lyophilization increased water solubility at least 30-fold times. These new DHQ modifications were studied by scanning electron microscopy, mass-spectrometry, nuclear magnetic resonance spectroscopy, infrared spectroscopy, X-ray powder diffraction, and thermal analysis. Their solid-state phases were confirmed to differ from the initial DHQ substance without any changes in the molecular structure. Both DHQE and DHQA showed as high antioxidant activity as the initial DHQ. These data demonstrate the potential of DHQE and DHQA as active pharmaceutical ingredients for injectable dosage forms.

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Cytotoxic effect of dihydroquercetin and its derivatives in liposomal form and in the form of fat nanoscale emulsions

Cited by 3 publications

References 14 publications

Antioxidant and Anti-Proliferative Properties of Hagenia abyssinica Roots and Their Potentially Active Components

Antioxidant and Anti-Proliferative Properties of Hagenia abyssinica Roots and Their Potentially Active Components

Unveiling the therapeutic potential of Taxifolin in Cancer: From molecular mechanisms to immune modulation and synergistic combinations

Solubility Enhancement of Dihydroquercetin via “Green” Phase Modification

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