Cytotoxic, DNA binding, DNA cleavage and antibacterial studies of ruthenium–fluoroquinolone complexes

Patel, Mohan N.; Joshi, Hardik; Patel, Chintan R.

doi:10.1007/s12039-014-0597-9

Cited by 22 publications

(20 citation statements)

References 49 publications

(40 reference statements)

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“…The synthesis of transition metal complexes that exhibit antimicrobial and catalase activities has gained interest in recent years due to their potential for application as inorganic pharmaceuticals in clinical therapy and diagnostics. [1][2][3][4][5][6][7] An increasing number of mono-and dinuclear Mn(III/II) complexes with catalase activity have been reported in the literature, most of them with Schiff base ligands. Following the first publication of the bipy and phen ligands of Mn(II) complexes by Fukuda and Sone in 1970, a large number of such compounds have been reported with different metals using mainly the same ligands with various anions.…”

Section: Introductionmentioning

confidence: 99%

Mn(II) complexes with bipyridine, phenanthroline and benzoic acid: Biological and catalase-like activity

2016

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Five mononuclear Mn(II) complexes, [Mn(phen) 2 (ClO 4) 2 ] (1), [Mn(phen) 3 ](ClO 4) 2 (H 2 CO 3) 2 (2), [Mn(bipy) 2 (ClO 4) 2 ] (3), [Mn(bipy) 3 ](ClO 4) 2) (4), and Mn(phen) 2 (ba)(H 2 O)](ClO 4)(CH 3 OH) (5), where bipy = 2,2'-bipyridine, phen = 1,10-phenanthroline, and ba = benzoic acid were prepared and characterized by Xray, IR and UV-Vis spectroscopies, and their catalase-like and biological activities were studied. The presence of two different types and the number of chelating NN-donor neutral ligands allowed for analysis of their effects on the catalase and biological activities. It was observed that the presence and number of phen ligands improved the activity more than the bipy ligand. Complexes 1 and 2, which contain more basic phen ligands, disproportionate H 2 O 2 faster than complexes 3 and 4, which contain less basic bipy ligands. The in vitro antimicrobial activities of all the complexes were also tested against seven bacterial strains by microdilution tests. All the bacterial isolates demonstrated sensitivity to the complexes and the antifungal (anticandidal) activities of the Mn(II) complexes were remarkably higher than the reference drug ketoconazole.

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Section: Introductionmentioning

confidence: 99%

Mn(II) complexes with bipyridine, phenanthroline and benzoic acid: Biological and catalase-like activity

2016

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“…All the experiments were carried out using an Ostwald capillary viscometer maintained at 25 ± 0.1°C. The flow time of the test compounds through the viscometer was determined in triplicate to get the average and accurate value (Patel et al 2014). The obtained data ploted as (η/η o ) 1/3 versus [compound]/[DNA], where η is the viscosity of Ct-DNA in the presence of compound and η o is the viscosity of Ct-DNA alone.…”

Section: Viscosity Measurementsmentioning

confidence: 99%

Investigation of DNA binding and molecular docking propensity of phthalimide derivatives: in vitro antibacterial and antioxidant assay

et al. 2019

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A series of N-substituted tetrabromphthalimide derivatives was synthesized by condensation reaction using tetrabromophthalic anhydride with 3,5-diamino-1,2,4-triazole/ 2,6-diaminopyridine/ 2,6-diamino-4-hydroxy pyrimidine/ o-tolidine. All the synthesized phthalimide derivatives were characterized by elemental analysis, infrared, and NMR spectroscopy. In vitro antibacterial evaluation was carried out for the synthesized compounds. Results revealed that compound 1 showed potential activity against Escherichia coli (100 μg/mL) and Streptococcus mutans (150 μg/mL). On the basis of antibacterial activity, compound 1 was selected for DNA binding interaction, though DNA target most of the antibacterial drugs. The DNA binding modes of the compound 1 with Ct-DNA (calf thymus) were studied by absorption measurements, hydrodynamic measurements and cyclic voltammetry methods. Molecular docking also confirms that compound 1 recognizes both the strands of the DNA dodecamer d(CGCGAATTC GCG) 2 within minor groove and showing the best binding capability with the duplex. Compound 1 also showed better antioxidant activity by 2,2-diphenyl-1-picryl-hydrazyl (DPPH) free radical and hydrogen peroxide.

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“…These peculiarities of ruthenium complexes can be partly explained by the ability of ruthenium to imitate iron in biological media, as well as by its rich coordination chemistry from the standpoint of available oxidative states, hydrolysis rates, and photochemistry. [106][107][108][109][110][111][112][113]…”

Section: Metal Complexesmentioning

confidence: 99%

Supramolecular interaction of transition metal complexes with albumins and DNA: Spectroscopic methods of estimation of binding parameters

Galkina

Проскурнин

2018

Applied Organom Chemis

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Binding parameters of metal complexes with albumins and DNA since the middle of 1990s are considered and summarized. The most widespread spectroscopic methods of estimation of binding parameters are discusseddirect fluorescent methods, indirect fluorescent methods (by fluorescence quenching parameters), and ways of estimation of binding constants by other optical spectroscopic methods. The methods and approaches to calculations used for the determination of binding constants are discussed. The data on the already found binding constants and kinetic parameters is systematized.KEYWORDS albumins, DNA, metal complexes, proteins, supramolecular interaction Funding information: Russian Foundation for Basic Research, Grant/Award Number: 16-03-01089_a 16-53-50027_YaF_a Abbreviations and designations used: F 0 , fluorescence intensity in the absence of a quencher; F, fluorescence intensity in the presence of a acid); NTSC, a new thiosemicarbazone; o-cbiaH, 5-(2-carboxybenzyloxy)isophthalic acid; o-van-gln, a Schiff base derived from o-vanillin and glutamine; o-van-L-met, Schiff base derived from o-vanillin and L-methionine; oxo, 5-

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Cytotoxic, DNA binding, DNA cleavage and antibacterial studies of ruthenium–fluoroquinolone complexes

Cited by 22 publications

References 49 publications

Mn(II) complexes with bipyridine, phenanthroline and benzoic acid: Biological and catalase-like activity

Mn(II) complexes with bipyridine, phenanthroline and benzoic acid: Biological and catalase-like activity

Investigation of DNA binding and molecular docking propensity of phthalimide derivatives: in vitro antibacterial and antioxidant assay

Supramolecular interaction of transition metal complexes with albumins and DNA: Spectroscopic methods of estimation of binding parameters

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