2003
DOI: 10.1021/np0303106
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Cytotoxic Cucurbitacin Constituents from Sloanea zuliaensis

Abstract: A new cucurbitacin D analogue, 2-deoxycucurbitacin D (1), as well as cucurbitacin D (2) and 25-acetylcucurbitacin F (3) were isolated from Sloanea zuliaensis. Compound 1 was found only in the young leaves of the plant and not in the mature leaves, and its structure was established using spectroscopic means. Compounds 1-3 demonstrated potent cytotoxic activity against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines.

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Cited by 30 publications
(20 citation statements)
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“…A new cucurbitacin D analog, 2-deoxycucurbitacin D as well as cucurbitacin D and 25-acetylcucurbitacin F have been isolated from the leaves of Sloanea zuliaensis . All these compounds have exhibited potent cytotoxic activity against MCF-7 human breast cancer cells (42). Bioassay-guided purification of the fruit extract of Cucurbita andreana yielded cucurbitacin B, D, E and I, which were evaluated for their inhibitory effects on the growth of MCF-7 cells.…”
Section: Triterpenoids and Breast Cancermentioning
confidence: 99%
“…A new cucurbitacin D analog, 2-deoxycucurbitacin D as well as cucurbitacin D and 25-acetylcucurbitacin F have been isolated from the leaves of Sloanea zuliaensis . All these compounds have exhibited potent cytotoxic activity against MCF-7 human breast cancer cells (42). Bioassay-guided purification of the fruit extract of Cucurbita andreana yielded cucurbitacin B, D, E and I, which were evaluated for their inhibitory effects on the growth of MCF-7 cells.…”
Section: Triterpenoids and Breast Cancermentioning
confidence: 99%
“…Studies indicate that various Elaeocarpus species contain chemical constituent such as triterpenes, tannins, indolizidine alkaloids, flavonoids, and ellagic acid derivatives 7,8,9 .…”
Section: Introductionmentioning
confidence: 99%
“…The plant is a creeping vine bearing cylindrical fruit which is thought to be one of the oldest vegetables cultivated by man with historical records dating back 5000 years back. [1] Traditionally cucumber has been used in diverse gastrointestinal problems [2] but now in light of its other chemical constituents it has a wide variety of applications such as hypolipidemic, [3] hypoglycemic, [4] anti-cancer, [5] hepatoprotective [6] and anti-inflammatory [7] . Different chemical compounds such as glycosides, many vitamins, sitosterol, bitter principle cucurbitacins, cucumegastigmanes, lactic acid, agmatine, [8] polyamines, [9] triterpenoids, polyphenols, flavonoids, many amino acids etc have been isolated.…”
Section: Introductionmentioning
confidence: 99%