Cytotoxic Cucurbitacin Constituents from Sloanea zuliaensis

Rodriguez, Nelson J.; Vásquez, Yelkaira; Hussein, Ahmed A.; Coley, Phyllis D.; Solís, Pablo N.; Gupta, Mahabir P.

doi:10.1021/np0303106

Cited by 30 publications

(20 citation statements)

References 8 publications

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“…A new cucurbitacin D analog, 2-deoxycucurbitacin D as well as cucurbitacin D and 25-acetylcucurbitacin F have been isolated from the leaves of Sloanea zuliaensis . All these compounds have exhibited potent cytotoxic activity against MCF-7 human breast cancer cells (42). Bioassay-guided purification of the fruit extract of Cucurbita andreana yielded cucurbitacin B, D, E and I, which were evaluated for their inhibitory effects on the growth of MCF-7 cells.…”

Section: Triterpenoids and Breast Cancermentioning

confidence: 99%

Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer

Bishayee

Ahmed²,

Brankov³

et al. 2011

Front Biosci

289

180

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Breast cancer remains a major cause of death in the United States as well as the rest of the world. In view of the limited treatment options for patients with advanced breast cancer, preventive and novel therapeutic approaches play an important role in combating this disease. The plant-derived triterpenoids, commonly used for medicinal purposes in many Asian countries, posses various pharmacological properties. A large number of triterpenoids are known to exhibit cytotoxicity against a variety of tumor cells as well as anticancer efficacy in preclinical animal models. Numerous triterpenoids have been synthesized by structural modification of natural compounds. Some of these analogs are considered to be the most potent antiinflammatory and anticarcinogenic triterpenoids known. This review examines the potential role of natural triterpenoids and their derivatives in the chemoprevention and treatment of mammary tumors. Both in vitro and in vivo effects of these agents and related molecular mechanisms are presented. Potential challenges and future directions involved in the advancement of these promising compounds in the prevention and therapy of human breast cancer are also identified.

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Section: Triterpenoids and Breast Cancermentioning

confidence: 99%

Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer

Bishayee

Ahmed²,

Brankov³

et al. 2011

Front Biosci

289

180

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“…Studies indicate that various Elaeocarpus species contain chemical constituent such as triterpenes, tannins, indolizidine alkaloids, flavonoids, and ellagic acid derivatives 7,8,9 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2014

IJPSR

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ABSTRACT:The in vitro antimicrobial activity of acetone, methanol and water extracts of leaf, stem bark and fruit of Elaeocarpus serratus L. (Elaeocarpaceae) was examined against four bacterial species (Shigella sonnei, Salmonella typhi, Staphylococcus aureus and Klebsiella pneumoniae) and a fungal species (Candida albicans) using the agar well diffusion method. Phytochemical screening was carried out for phenols, flavonoids and tannins. Results showed that the plant extracts exhibited a dose-dependent inhibition of microorganisms. The acetone and methanol extracts of leaf and stem bark of E. serratus displayed maximum antibacterial activity against all the bacterial species studied. The plant extracts also displayed high antifungal activity against Candida albicans especially, the acetone extract was found to be more active antifungal. Generally, the lower concentrations of the extracts were susceptible to the fungal pathogen. E. serratus extracts contained phenols, flavonoids and tannins at varying levels. The ability of the crude extracts of the test plant to inhibit the growth of bacteria and fungi is an indication of its broad spectrum antimicrobial potential which may be employed in the management of microbial infections.

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“…The plant is a creeping vine bearing cylindrical fruit which is thought to be one of the oldest vegetables cultivated by man with historical records dating back 5000 years back. [1] Traditionally cucumber has been used in diverse gastrointestinal problems [2] but now in light of its other chemical constituents it has a wide variety of applications such as hypolipidemic, [3] hypoglycemic, [4] anti-cancer, [5] hepatoprotective [6] and anti-inflammatory [7] . Different chemical compounds such as glycosides, many vitamins, sitosterol, bitter principle cucurbitacins, cucumegastigmanes, lactic acid, agmatine, [8] polyamines, [9] triterpenoids, polyphenols, flavonoids, many amino acids etc have been isolated.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Evaluation of Cucumber for Cognition Enhancing Effect on Brain of Mice

Kumar¹,

Parle²

2014

Phcog J.

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Introduction: Cucumber is fruit of Cucumis sativus var. sativus L. which has been used traditionally in gastrointestinal problems, skin problems and as coolant in salad for body and brain. Cucumber is a great folk medicine used to reduce heat and inflammation. Cognitive effects of cucumber are assessed in this study. Methods: Fresh fruits of Cucumis sativus L. were ground and a paste was prepared which consisted of different concentrations of cucumber (30, 60, 90 % w/w). The three doses were given ad libitum to mice for 15 successive days. Animal models utilized were sodium nitrite induced hypoxia and object recognition task. Biochemical analysis employed estimation of acetylcholinesterase activity in brain, serum glucose levels, cholesterol levels, brain lipid peroxidation (MDA) levels and reduced glutathione levels in brain of mice. Results: 6g/kg and 9g/kg doses of cucumber significantly (P < 0.05, P < 0.01) increased frequency of entry, number of entry and duration of entry in small compartment in sodium nitrite induced hypoxia model and depicted significantly (P < 0.05, P < 0.001) enhanced exploratory activity in object recognition task model. Further, biochemical analysis indicated good potential of cucumber in cognition enhancement. 9 g/kg dose (P < 0.001) reduced brain AChE activity along with blood glucose and serum cholesterol levels. 6 g/kg dose (P < 0.01) replenished brain GSH levels and reduced lipid peroxides. Conclusion: Cucumber increased cognition in rodents.

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Cytotoxic Cucurbitacin Constituents from Sloanea zuliaensis

Cited by 30 publications

References 8 publications

Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer

Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer

Untitled

Pharmacological Evaluation of Cucumber for Cognition Enhancing Effect on Brain of Mice

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