Cytotoxic constituents from Plumbago zeylanica

Nguyen, Anh Tho; Malonne, Hugues; Duez, Pierre; Vanhaelen-Fastré, Renée; Vanhaelen, Maurice; Fontaine, Jeanine

doi:10.1016/j.fitote.2004.03.009

Cited by 85 publications

(62 citation statements)

References 8 publications

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“…Previous studies have suggested that populations with the low breast cancer incidence often consume high phytosterols containing diets, including b-sitosterol (Muti et al 2003). In vitro studies have shown that b-sitosterol inhibits 66% of the growth and stimulate the apoptosis of MDA-MB-231 human breast cancer cells in culture at 16 mM (Awad et al 2000) and it also has a selective cytotoxic activity against Bowes (melanoma) cells with an IC 50 value of 36.5 mM (Nguyen et al 2004). Furthermore, compound 3 has exhibited inhibitory effect on tumour-promotion in JB6 mouse epidermal cells (IC 50 39.6 mmol/L) (Gao et al 2003).…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic activity and chemical constituents ofAnthemis mirheydari

Jassbi

Firuzi

Miri

et al. 2016

Pharmaceutical Biology

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Context The genus Anthemis L. (Asteraceae) comprises about 195 species which are widely used in the pharmaceutical, cosmetic and food industries. Objective Anthemis mirheydari Iranshar, an endemic plant from Iran, was investigated for its cytotoxic properties and chemical constituents. Materials and methods The whole parts of the plant (320 g) were extracted by dichloromethane and methanol for four days, successively. The cytotoxic activity of both dichloromethane and methanol extracts were assayed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric methods against three human cancer cell lines including LS180, MCF-7 and MOLT-4. Different concentrations (10-100 mg/mL) of the plant extracts were tested to obtain IC 50 values. The dichloromethane extract of A. mirheydari was subjected to silica gel-column and thin layer chromatography for purification of its chemical constituents and the isolated compounds were further tested against MOLT-4 cells. The structures of the pure compounds were elucidated using different spectral data including nuclear magnetic resonance and electron impact mass spectra. Results The IC 50 values of the dichloromethane extract were 30.8 ± 6.7, 25.2 ± 6.5 and 8.6 ± 1.1 mg/mL (means ± standard error) for the above-mentioned cell lines, respectively. Two triterpenoids, taraxasterol (1) and pseudotaraxasterol (2), one sterol, b-sitosterol (3) and one coumarin, 7-methoxycoumarin (4) were isolated from the extract. The IC 50 of the mixture of compounds 1 and 2 as well as compounds 3 and 4 were higher (4100 mM) than that reported for the dichloromethane extract against MOLT-4 cells. Conclusion The dichloromethane extract was the most active one among the tested material.ARTICLE HISTORY

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Section: Resultsmentioning

confidence: 99%

Cytotoxic activity and chemical constituents ofAnthemis mirheydari

Jassbi

Firuzi

Miri

et al. 2016

Pharmaceutical Biology

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“…The structures of the five other known compounds were established as β-sitosterol (1) (Xiao et al, 2002), umbelliferone (2) (Ngadjui et al, 1991), scopoletin (3) (Cardona et al, 1992), benjaminamide (4) (Simo et al, 2008) and β-sitosterol-3-O-β-D-glucopyranoside (5) (Nguyena et al, 2004) by comparing of their spectral and physical data with those published before ( Figure 2). β-sitosterol (compound 1): Colourless needles, mp 139─140 °C.…”

Section: Resultsmentioning

confidence: 99%

Xanthine oxidase inhibitory activity of compounds from <i>Chythrantus claneianus</i>

Gojayev

Bankeu

Awantu

et al. 2013

Bangladesh J Pharmacol

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“…Coumarin, flavonoid and sitosterol 8,14 are phytoconstituents that have been related to the occurrence of certain adverse effects to the reproductive system and hence possess a potent antifertility activity. Flavonoids like quercitin, apigenin 2,5 , luteolin 2,5 and β-sitosterol 8,14 are the active constituents of this plant that suggests the possible antifertility activity in female rats.…”

Section: Antifertility Activitymentioning

confidence: 99%

“…8,14,44 Rahman et al have evaluated anticancer activity (apoptosis inducing effect) of methanolic extract of C. dichotoma leaves on human cervical cancer cell line, HeLa and to determine total phenolic content. MTT assay and DAPI staining test were performed to evaluate anticancer potential and to assess apoptosis induced effect of methanolic extract of C. dichotoma leaves (MECD) against human cervical cancer cell line (HeLa).…”

Section: Anticancer Activitymentioning

confidence: 99%

Exploring Phytochemicals and Pharmacological Uses of Cordia Dichotoma (Indian Cherry): A Review

Prajapati

Kar

Maurya

et al. 2017

J. Drug Delivery Ther.

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The use of phytoconstituents single or combined with standard medicines has been utilized in cure of different diseases. Many plants of genus Cordia comprise of trees and shrubs are widely distributed in warmer regions and have been utilized in management of various diseases. Various phytoconstituents like flavonoids, alkaloids, terpenes, tannins, and glyceridess having different activities were screened and isolated from different parts of C. dichotoma. Various important Pharmacological properties including Antiulcer, Contraceptives, anti-inflammatory, anthelmintic, analgesic, anticancer, Antioxidant, antimicrobial, hepatoprotective, antidiabetic and others have been well documented for this plant. Therefore, we have briefly reviewed the various bioactivities of C. dichotoma to improve our knowledge on plant phytochemicals as therapeutic entities. The present review describes the various phytoconstituents and therapeutic potential of C. dichotoma that can be followed for future research on this plant for human health benefits.

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Cytotoxic constituents from Plumbago zeylanica

Cited by 85 publications

References 8 publications

Cytotoxic activity and chemical constituents ofAnthemis mirheydari

Cytotoxic activity and chemical constituents ofAnthemis mirheydari

Xanthine oxidase inhibitory activity of compounds from <i>Chythrantus claneianus</i>

Exploring Phytochemicals and Pharmacological Uses of Cordia Dichotoma (Indian Cherry): A Review

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