Cytotoxic cardenolides and sesquiterpenoids from the fruits of Reevesia formosana

Hsiao, Pei-Yu; Lee, Shiow‐Ju; Chen, Ih-Sheng; Hsu, Hsing-Yu; Chang, Hsueh‐Wei

doi:10.1016/j.phytochem.2016.06.009

Cited by 11 publications

(9 citation statements)

References 39 publications

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“…The known compounds lincomolide A ( 3 ) [ 24 ], linderanolide B ( 4 ) [ 25 ], isolinderanolide B ( 5 ) [ 25 ], isophilippinolide A ( 6 ) [ 26 ], secosubamolide ( 7 ) [ 27 ], reticuol ( 8 ) [ 28 ], burmanol ( 9 ) [ 29 ], (−)-5,7-dimethoxy-3′,4′-methylenedioxy-flavan-3-ol ( 10 ) [ 30 ], taxifolin ( 11 ) [ 31 ], (−)-yangambin ( 12 ) [ 32 ], (−)-pinoresinol ( 13 ) [ 33 ], (+)-monomethylpinoresinol ( 14 ) [ 34 ], (+)-syringaresinol ( 15 ) [ 33 ], erythro -guaiacylglycerol- β - O -4′-(5′)-methoxylariciresinol ( 16 ) [ 35 ], caryolane-1,9 β -diol ( 17 ) [ 36 ], β -sitosterol ( 18 ) [ 37 ], and cinnamtannin B1 ( 19 ) [ 38 ] were identified by comparisons of physical and spectroscopic data ([α] D , UV, IR, 1 H NMR, and MS) with authentic samples or literature data. Among them, cinnamtannin B1 ( 19 ) (3.6 g) was obtained as the major constituent.…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve

Yang

Hwang

et al. 2020

Molecules

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One new dibenzocycloheptene, validinol (1), and one butanolide firstly isolated from the natural source, validinolide (2), together with 17 known compounds were isolated from the stem of Cinnamomum validinerve. Among the isolates, lincomolide A (3), secosubamolide (7), and cinnamtannin B1 (19) exhibited potent inhibition on both superoxide anion generation (IC50 values of 2.98 ± 0.3 µM, 4.37 ± 0.38 µM, and 2.20 ± 0.3 µM, respectively) and elastase release (IC50 values of 3.96 ± 0.31 µM, 3.04 ± 0.23 µM, and 4.64 ± 0.71 µM, respectively) by human neutrophils. In addition, isophilippinolide A (6), secosubamolide (7), and cinnamtannin B1 (19) showed bacteriostatic effects against Propionibacterium acnes in in vitro study, with minimal inhibitory concentration (MIC) values at 16 μg/mL, 16 μg/mL, and 500 μg/mL, respectively. Further investigations using the in vivo ear P. acnes infection model showed that the intraperitoneal administration of the major component cinnamtannin B1 (19) reduced immune cell infiltration and pro-inflammatory cytokines TNF-α and IL-6 at the infection sites. The results demonstrated the potential of cinnamtannin B1 (19) for acne therapy. In summary, these results demonstrated the anti-inflammatory potentials of Formosan C. validinerve during bacterial infections.

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Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve

Yang

Hwang

et al. 2020

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“…1 Reevesiterpenol E also displayed the best selective cytotoxicity to the NCI-H460 cell line. 2 Therefore, the cardenolides and furanosesquiterpenoids from R. formosana are hopeful to be candidates for the discovery of anticancer compounds, primarily, the anticancer mechanisms had been studied by our research group. Such as reevesioside A induced G1 arrest and suppressed the expression of c-myc of human hormone-refractory prostate cancer, 3 and the anti-proliferative activity of reevesioside F was conrmed to be Na + /K + -ATPase a3 subunitdependent 4 whereas the function of epi-reevesioside F was further identied to be PI3-kinase/Akt pathway related.…”

Section: Resultsmentioning

confidence: 99%

“…Continuing these rigorous studies, three cardenolides: reevesioside J, reevesioside K, and epi-reevesioside K, three sesquiterpenoids: reevesiterpenols C-E, and two glycosides: reevesianins A and B, along with 46 known compounds were also isolated from the fruits of R. formosana. 2 Among these isolates, all cardenolides showed signicant cytotoxicity against MCF-7, NCI-H460, and HepG2 cancer cell lines and reevesiterpenol E also exhibited the best selective cytotoxicity to the NCI-H460 cell line. Furthermore, reevesioside A, 3 reevesioside F, 4 and epi-reevesioside F 5 had already been discussed for the mechanism of several cancer cells.…”

Section: Introductionmentioning

confidence: 96%

“…In this study, we investigated the stem of R. formosana and the remaining fractions of the root of R. formosana. From these two parts led to the isolation of six new compounds including three lignanoids: reevesiacoumarin (1), reevesic acid (2), and reevesilignan (3), and three terpenoids: reevesiterpenol A (4), reevesiterpenol B (5), and 3a,27-di-O-trans-caffeoylbetulinic acid (6) (Fig. 1), along with 40 known compounds.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive composition of Reevesia formosana root and stem with cytotoxic activity potential

et al. 2017

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“…Прогнозування та оцінка терапевтичного ефекту обраної схеми лікування на основі фармакокінетичних параметрів ґрунтується на математичному моделюванні, яке засноване на концентрації лікарського засобу у крові, визначення якої називають терапевтичним лікарським моніторингом (ТЛМ). Кінетичний підхід до моніторингу лікування ґрунтується на припущенні, що величина терапевтичного та токсичного ефектів залежить від дози, а також від концентрації діючої речовини у крові [5,6,11]. Однак, антибіотики різних груп за рахунок особливостей хімічної структури, мають різні властивості.…”

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Intake and distribution of doxycycline in the organism of broiler chickens

Tyshkivskaya

Dukhnytskyi

Tyshkivsky

2020

Nauk. vìsn. vet. med.

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The article presents the results of studies on the absorption, distribution and excretion of the antibiotic Poledoxin (the active substance is doxycycline hyclact) from the body of healthy broiler chickens of the Koob-500 cross when taken orally. Studies have established the rapid absorption of doxycycline hyclact from the digestive tract of the chicken into the blood and its entry into the internal organs. The maximum concentration of doxycycline hyclact was detected 2-4 hours after the start of Poledoxin administration, the content of which in the liver was 9,07±0,07 μg/g, in the lungs – 8,39±0,20 μg/g, in the heart – 4,24±0,09 μg/g, in the pectoral muscles – 4,28±0,23 μg/g. In the kidneys, the maximum concentration was found after 12 hours – 7,63±0,38 μg/g. When clinically healthy broiler chickens were fed with Poledoxin solution, the ability to materially cumulate doxycycline hyclact (active ingredient) was not established, since its content in the internal organs and muscles of the bird did not depend on the duration of the drug use. Studies have established the absence of organ affiliation of doxycycline hyclact, because its maximum content, depending on the study period, was recorded in various organs that provide biotransformation and excretion – liver, kidneys, lungs. The cancellation of drinking Poledoxin ensured the rapid elimination of doxycyclin hyclact from the body of broiler chickens and, after 5 days (for 216 hours of the experiment), its content was minimal for the entire study period and amounted to: in the kidneys – 0,15±0,01 μg/g; liver – 0,12±0,01 μg/g; pectoral muscles – 0,05±0,01 μg/g; lungs – 0,04±0,01 μg/g. Only in one sample of the heart, doxycycline hyclact was shown in an amount of 0,01 μg/g. Key words: Poledoxin, doxycycline hyclact, broiler chickens, distribution, accumulation, hatching, bioavailability, pharmacokinetics, excretion.

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Cytotoxic cardenolides and sesquiterpenoids from the fruits of Reevesia formosana

Cited by 11 publications

References 39 publications

Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve

Anti-Inflammatory and Antibacterial Activity Constituents from the Stem of Cinnamomum validinerve

Bioactive composition of Reevesia formosana root and stem with cytotoxic activity potential

Intake and distribution of doxycycline in the organism of broiler chickens

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