Cytotoxic, antibacterial, DNA interaction and superoxide dismutase like activities of sparfloxacin drug based copper(II) complexes with nitrogen donor ligands

Patel, Mohan N.; Joshi, Hardik; Patel, Chintan R.

doi:10.1016/j.saa.2012.11.045

Cited by 53 publications

(13 citation statements)

References 51 publications

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“…Transition metal complexes have been utilized in the area of drug design. Thus, special attention has been paid to the interaction between transition metal complexes and DNA …”

Section: Introductionmentioning

confidence: 99%

2,4‐Dihydroxy‐5‐[(5‐mercapto‐1H‐1,2,4‐triazole‐3‐yl)diazenyl]benzaldehyde acetato, chloro and nitrato Cu(II) complexes: Synthesis, structural characterization, DNA binding and anticancer and antimicrobial activity

Gaber

Fathalla

El‐Ghamry

2019

Applied Organom Chemis

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Acetato, chloro and nitrato Cu(II) complexes of a novel azo compound, namely 2,4‐dihydroxy‐5‐[(5‐mercapto‐1H‐1,2,4‐triazole‐3‐yl)diazenyl]benzaldehyde, have been prepared. The stoichiometry, stereochemistry and bonding fashion of these copper chelates were deduced via elemental analyses, spectral methods and conductivity and magnetic measurements. Infrared spectral data confirmed the participation of azo N atom and the deprotonated OH group. UV–visible spectral data and magnetic measurements indicated octahedral stereo‐structure for the acetato and nitrato compounds and square planer for the chloro compound. Thermogravimetric analysis was applied to investigate the thermal degradation of the metal chelates. The thermo‐kinetic parameters were computed. The molecular modeling technique was used to support the predicted geometry of the prepared chelates. The interaction between the Cu(II) complexes and calf thymus DNA was studied using two techniques: absorption and viscosity measurements. The values of binding constant obtained from the absorption spectral method were calculated and found to be 4.23 × 104, 26.93 × 104, 13.01 × 104 and 5.36 × 104 M−1 for ligand and acetato, chloro and nitrato complexes, respectively. The antimicrobial activities were evaluated against various bacterial and fungi strains. The in vitro antitumor efficacy of the synthesized compounds was investigated against the HEPG2 cell line.

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“…Transition metal complexes have been utilized in the area of drug design. Thus, special attention has been paid to the interaction between transition metal complexes and DNA …”

Section: Introductionmentioning

confidence: 99%

2,4‐Dihydroxy‐5‐[(5‐mercapto‐1H‐1,2,4‐triazole‐3‐yl)diazenyl]benzaldehyde acetato, chloro and nitrato Cu(II) complexes: Synthesis, structural characterization, DNA binding and anticancer and antimicrobial activity

Gaber

Fathalla

El‐Ghamry

2019

Applied Organom Chemis

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“…It has been proved that the incorporation of a metal into the 4‐oxo‐3‐carboxylic acid motif is vital process in the action mechanism of 4‐quinolones , so 4‐quinolone metal complex may be promising antibacterial candidates. Several FQs including enoxacin , CPFX , NRFX , OLFX , LVFX , SPFX , GTFX , and MXFX metal complexes were synthesized and screened for their in vitro biological activities by different research groups. All complexes displayed considerable antibacterial activities, and almost all of them were as potent as or more active than the parent drugs against Gram‐negative pathogens.…”

Section: Structure–activity Relationshipmentioning

confidence: 99%

4‐Quinolone Derivatives and Their Activities Against Gram‐negative Pathogens

Jiang

2018

Journal of Heterocyclic Chem

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Gram‐negative pathogens represent a significant global health threat, while the emergency and widespread of drug resistance make the situation even worse. As “privileged building blocks,” 4‐quinolones including fluoroquinolones are mainstays of chemotherapy against various bacterial infections. However, as other antibiotics, the resistance of Gram‐negative bacteria to 4‐quinolones develops rapidly and spreads widely throughout the world. To overcome the resistance and improve the potency, a number of 4‐quinolone derivatives were designed, synthesized, and screened for their in vitro and in vivo activities against representative Gram‐negative pathogens. This review aims to summarize the recent advances made towards the discovery of 4‐quinolone derivatives as anti‐Gram‐negative agents as well as their structure–activity relationship. The enriched structure–activity relationship paves the way to the further rational development of 4‐quinolones with excellent potency against both drug‐susceptible and drug‐resistant Gram‐negative pathogens.

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“…Metal complexes are stabilized on groove binding with DNA through a series of weak interactions, such as p-stacking, hydrogen bond, attractive van der Waals, and hydrophobic interaction. The overlap between electronic clouds of aromatic molecules and purines or pyrimidines of double-stranded DNA leads to the stacking interactions and contacts with the edges of the base pairs result in DNA groove binding (Patel, Joshi, & Patel, 2013).…”

Section: Introductionmentioning

confidence: 99%

DNA interaction of europium(III) complex containing 2,2′-bipyridine and its antimicrobial activity

Jahani

Khorasani-Motlagh

Noroozifar

2015

Journal of Biomolecular Structure and Dynamics

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The interaction of native fish salmon DNA (FS-DNA) with [Eu(bpy)3Cl2(H2O)]Cl, where bpy is 2,2'-bipyridine, is studied at physiological pH in Tris-HCl buffer by spectroscopic methods, viscometric techniques as well as circular dichroism (CD). These experiments reveal that Eu(III) complex has interaction with FS-DNA. Moreover, binding constant and binding site size have been determined. The value of Kb has been defined 2.46 ± .02 × 10(5) M(-1). The thermodynamic parameters are calculated by Van't Hoff equation, the results show that the interaction of the complex with FS-DNA is an entropically driven phenomenon. CD spectroscopy followed by viscosity as well as fluorescence and UV--Vis measurements indicate that the complex interacts with FS-DNA via groove binding mode. Also, the synthesized Eu(III) complex has been screened for antimicrobial activities.

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Cytotoxic, antibacterial, DNA interaction and superoxide dismutase like activities of sparfloxacin drug based copper(II) complexes with nitrogen donor ligands

Cited by 53 publications

References 51 publications

2,4‐Dihydroxy‐5‐[(5‐mercapto‐1H‐1,2,4‐triazole‐3‐yl)diazenyl]benzaldehyde acetato, chloro and nitrato Cu(II) complexes: Synthesis, structural characterization, DNA binding and anticancer and antimicrobial activity

2,4‐Dihydroxy‐5‐[(5‐mercapto‐1H‐1,2,4‐triazole‐3‐yl)diazenyl]benzaldehyde acetato, chloro and nitrato Cu(II) complexes: Synthesis, structural characterization, DNA binding and anticancer and antimicrobial activity

4‐Quinolone Derivatives and Their Activities Against Gram‐negative Pathogens

DNA interaction of europium(III) complex containing 2,2′-bipyridine and its antimicrobial activity

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