Cytotoxic, Anti-Proliferative and Apoptotic Effects of Tribulus terrestris L. Fruit Extract on Human Prostate Cancer Lncap and Colon Cancer HT-29 Cell Lines

Pourali, Masoud; Yaghoobi, Mohammad; Sormaghi, M H Salehi

doi:10.17795/jjnpp-33561

Cited by 1 publication

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References 5 publications

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“…In the study by Apurva et al, the extract of the Tribulus terrestris plant seems to increase the caspase 3 activity of the human breast cancer cell line [51]. In the study by Masoud et al, the herb is also found to have anticancer activity against prostate and colon cancer cell lines [52]. It was inferred that the aqueous extract of the plant had a high cytotoxic effect and it can be suggested for marketing in the study by Claudio et al [53].…”

Section: Resultsmentioning

confidence: 98%

Evaluation of Antitumour Activity of Ethanolic Extract from Tribulus terrestris in Human Breast Cancer Cells

Kamalli

Subramanian

Ezhilarasan

et al. 2021

JPRI

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Introduction: Breast cancer is the form of cancer that occurs in the breast cells. After skin cancer, breast cancer is considered to be the most common cancer diagnosed in women. The number of deaths associated with this disease was increased in case of lack of early detection. Tribulus terrestris is an annual herb belonging to the Zygophyllaceae family. Flavonoids, alkaloids, and saponins are some of the main phytoconstituents of the herb. They are known for their pharmacological actions such as anti carcinogenic, anti inflammatory, antimicrobial, antioxidant properties. Aim: The aim of the present study is to evaluate the antitumor activity of ethanolic extract from Tribulus terrestris in MCF-7 human breast cancer cells. Materials and Methods: The effect of Tribulus terrestris on cell viability was measured by MTT assay carried against breast cancer cells and morphological changes were investigated with phase contrast microscopy to confirm its antitumor activity. Results: the cell viability assay results indicate that 24hrs treatment with ethanolic extract of significantly reduces the cell viability in dose dependent manner. At 40 μg/ml of the Tribulus terrestris extract inhibits 50% cell viability and it has been fixed as IC50 value for further Tribulus terrestris experiments. Conclusion: From the results, the extracts were cytotoxic to the human breast cancer cell and it might be a good therapeutic value for further investigations needed to understand the mechanisms to develop antitumor agents.

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Section: Resultsmentioning

confidence: 98%

Evaluation of Antitumour Activity of Ethanolic Extract from Tribulus terrestris in Human Breast Cancer Cells

Kamalli

Subramanian

Ezhilarasan

et al. 2021

JPRI

View full text Add to dashboard Cite

show abstract

Cytotoxic, Anti-Proliferative and Apoptotic Effects of Tribulus terrestris L. Fruit Extract on Human Prostate Cancer Lncap and Colon Cancer HT-29 Cell Lines

Abstract: Background: The medicinal herb Tribulus terrestris L. (Zygophyllaceae) has been used for a long time to treat various kinds of diseases including hepatocellular carcinoma.

Cited by 1 publication

References 5 publications

Evaluation of Antitumour Activity of Ethanolic Extract from Tribulus terrestris in Human Breast Cancer Cells

Evaluation of Antitumour Activity of Ethanolic Extract from Tribulus terrestris in Human Breast Cancer Cells

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