Cytotoxic and PPARs transcriptional activities of sterols from the Vietnamese soft coral Lobophytum laevigatum

Quang, Trần Hồng; Ha, Tran Thu; Minh, Châu Văn; Kiệm, Phan Văn; Hương, Hoàng Thanh; Ngân, Nguyễn Thị Thanh; Nhiệm, Nguyễn Xuân; Tung, Nguyen Hưu; Thảo, Nguyễn Phương; Thuy, Dinh Thi Thu; Song, Seung‐Wan; Boo, Hye‐Jin; Kang, Hee‐Kyoung; Kim, Young Ho

doi:10.1016/j.bmcl.2011.03.089

Cited by 18 publications

(10 citation statements)

References 20 publications

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“…Among them, compounds (22 S ,24 S )-24-methyl-22,25-epoxyfurost-5-ene-3β,20β-diol ( 201 ), (24 S )-ergost-5-ene-3β,7 α -diol ( 202 ), and pregnenolone ( 203 ) (Figure 26) significantly upregulated PPAR transcriptional activity dose-dependently in Hep-G2 cells. At a concentration of 1 μM, compounds 201 – 203 enhanced PPAR transcriptional activity by 1.4-, 1.2-, and 1.6-fold, respectively [169]. Chemical investigation of the coral Sarcophyton trocheliophorum Marenzeller yielded two new sarsolenane diterpenes and two new capnosane diterpenes, together with the known analogue.…”

Section: Bioactive Compounds From Coralmentioning

confidence: 99%

Coral and Coral-Associated Microorganisms: A Prolific Source of Potential Bioactive Natural Products

et al. 2019

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Marine invertebrates and their associated microorganisms are rich sources of bioactive compounds. Among them, coral and its associated microorganisms are promising providers of marine bioactive compounds. The present review provides an overview of bioactive compounds that are produced by corals and coral-associated microorganisms, covering the literature from 2010 to March 2019. Accordingly, 245 natural products that possess a wide range of potent bioactivities, such as anti-inflammatory, cytotoxic, antimicrobial, antivirus, and antifouling activities, among others, are described in this review.

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Section: Bioactive Compounds From Coralmentioning

confidence: 99%

Coral and Coral-Associated Microorganisms: A Prolific Source of Potential Bioactive Natural Products

et al. 2019

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Section: Steroids Derived From the Other Coral's Generamentioning

confidence: 99%

“…produces bioactive 9,11-secosteroids, pinnisteroids A and C (92 and 93) displayed remarkable inhibitory effects on the generation of superoxide anions and the release of elastase in human neutrophils, with IC50 values from 2.3 to 3.3 µM [110]. The soft coral Lobophytum laevigatum contained unusual steroid, (22S,24S)-24-methyl-22,25-epoxyfurost-5-ene-3β,20β-diol (94) and demonstrated significantly upregulated PPAR transcriptional activity dose-dependently in Hep-G2 cells [111]. Marine withanolides, paraminabeolides A (120), B (121), C (122), D (123) and F ( 124) and same compounds named minabeolides 1 (125) and 5 (126) were obtained from lipid extracts of the Formosan soft coral Paraminabea acronocephala.…”

Section: Steroids Derived From the Other Coral's Generamentioning

confidence: 99%

Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities

et al. 2020

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The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxygenated steroids and steroids containing sulfur or nitrogen heteroatoms. Of greatest interest is the pharmacological activity of these steroids. More than 40 steroids exhibit antitumor and related activity with a confidence level of over 90 percent. A group of 32 steroids shows anti-hypercholesterolemic activity with over 90 percent confidence. Ten steroids exhibit anti-inflammatory activity and 20 steroids can be classified as respiratory analeptic drugs. Several steroids exhibit rather rare and very specific activities. Steroids exhibit anti-osteoporotic properties and can be used to treat osteoporosis, as well as have strong anti-eczemic and anti-psoriatic properties and antispasmodic properties. Thus, this review is probably the first and exclusive to present the known as well as the potential pharmacological activities of 200 marine steroids.

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“…ở Cồn Cỏ, Quảng Trị [75]. Một số các chất mới và cả các chất đã được công bố có hoạt động kháng lại nhiều dòng tế bào ung thư khác nhau từ san hô mềm Lobophytum laevigatum ở Khánh Hòa [76,77]. Polyoxygenated steroids có khả năng kháng viêm từ san hô mềm Sarcophyton pauciplicatum ở Hải Phòng [78], cembranoid diterpenoids thể hiện khả năng antiinflammatory từ san hô mềm Lobophytum crassum ở Cồn Cỏ, Quảng Trị [79] cũng đã được tìm thấy.…”

Section: Cơ Hội Và Thách Thức đốI Với Nghiên Cứu Trong Nướcunclassified

Marine Microbes: Sources of Natural Bioactive Compounds for Application in Pharmaceutical Research

Mien¹,

Ha²

2017

VJMST

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Marine microbiology is currently the topic that scientists worldwide are interested in with the aim of searching for bioactive substances. In addition to the inherent microorganisms in marine sediments, other marine lives - associated microorganisms have recently been more invested and important achievements of pharmaceutical research applications have been gained in the last few decades. In this article, we review the milestones in the process of looking for “drugs from the sea” and focus on remarkable results in marine microbes associated with invertebrate and their potential application in drug investigation from the latest published papers in prestigious international journals.

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Cytotoxic and PPARs transcriptional activities of sterols from the Vietnamese soft coral Lobophytum laevigatum

Cited by 18 publications

References 20 publications

Coral and Coral-Associated Microorganisms: A Prolific Source of Potential Bioactive Natural Products

Coral and Coral-Associated Microorganisms: A Prolific Source of Potential Bioactive Natural Products

Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities

Marine Microbes: Sources of Natural Bioactive Compounds for Application in Pharmaceutical Research

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