Cytotoxic and neurotoxic activities in extracts of marine sponges (Porifera) from southeastern Brazilian coast

Rangel, Marisa; Sanctis, Bianca De; Freitas, José Carlos de; Polatto, Juliana Moutinho; Granato, Ana Cláudia; Berlinck, Roberto G. S.; Hajdu, Eduardo

doi:10.1016/s0022-0981(01)00276-3

Cited by 36 publications

(24 citation statements)

References 24 publications

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“…The pharmacological evaluation of crude extracts obtained from a limited number of Brazilian marine invertebrates illustrated potential cytotoxic (Rangel et al, 2001;Monks et al, 2002;Jimenez et al, 2003;Prado et al, 2004), antimicrobial (Muricy et al, 1993;Monks et al, 2002), hemolytic and neurotoxic (Rangel et al, 2001;Dresch et al, 2005) activities. The present investigation reports the pharmacological evaluation of more than 300 crude extracts obtained from marine sponges, ascidians, bryozoans and octocorals, in bioassays of antimycobacterial activity against Mycobacterium tuberculosis H37Rv, antibiotic activity against sixteen susceptible and resistant strains of bacteria and Candida albicans, inhibition of the enzyme adenine phosphoribosyl transferase of Leishmania tarentolae (L-APRT), as well as cytotoxic activity against colon (HCT8), melanoma (B16) and breast (MCF-7) cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic, cytotoxic and enzyme inhibitory activity of crude extracts from Brazilian marine invertebrates

Seleghim¹,

Lira²,

Kossuga³

et al. 2007

Rev. bras. farmacogn.

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Section: Introductionmentioning

confidence: 99%

Antibiotic, cytotoxic and enzyme inhibitory activity of crude extracts from Brazilian marine invertebrates

Seleghim¹,

Lira²,

Kossuga³

et al. 2007

Rev. bras. farmacogn.

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“…Rangel et al (2001), Seleghim et al (2007) Canal de São Sebastião 11-20 Clathrina tetractina Klautau & Borojevic, 2001Lanna et al (2007 Canal …”

Section: -25mentioning

confidence: 99%

“…Aaptos sp. Granato et al (2000), Rangel et al (2001), Muricy & Hajdu (2006), Seleghim et al (2007) Canal de São Sebastião 1-15…”

Section: -100mentioning

confidence: 99%

Checklist de Porifera do Estado de São Paulo, Brasil

Custódio

Hajdu

2011

Biota Neotrop.

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Abstract:The sponges (Porifera) are one of the oldest extant metazoans, but still easily found in a wide variety of aquatic environments. They are key components in several ecosystems, directly influencing the quality of water in their habitat. In recent times, these organisms have become one of the most productive groups in providing new compounds with bioactivity or unusual structures. However, sponges are historically considered a group of complex taxonomy, and systematic discussions at order level or even about the monophyly of the group are still common. This situation began to change markedly in the last decade, with multinational initiatives aimed at providing a more solid taxonomic basis. In Brazil, this process was accompanied by the publication of identification guides of the native species. Starting from the sporadic data available in earlier periods, several initiatives were specifically targeted at the survey of Porifera species, particularly in coastal regions. Such actions now provide the researchers with a knowledge base far more comprehensive than that available a decade earlier. In the ten years since the last checklists for the São Paulo State were published, there was a significant change in the scenario. As verified by this study, the period was undoubtedly the most prolific regarding the knowledge of the local spongiofauna. Resumo: As esponjas (Filo Porifera) são um dos metazoários mais antigos existentes, mas ainda facilmente encontradas em uma grande variedade de ambientes aquáticos. São um componente fundamental em diversos ecossistemas, influenciando diretamente a qualidade da água em seus habitats. Em tempos recentes são um dos grupos que mais fornece novas moléculas bioativas ou com estruturas incomuns. No entanto, são historicamente considerados um grupo de taxonomia complexa e ainda são comuns discussões acerca da sistemática ao nível de ordens ou mesmo da monofilia do grupo. Este cenário começou a ser alterado de forma marcante na última década, a partir de iniciativas multinacionais voltadas a fornecer uma base taxonômica mais sólida. No Brasil, este processo foi acompanhado pela publicação de guias de identificação para as esponjas do nosso litoral. Partindo dos dados esporádicos disponíveis em períodos anteriores, diversas iniciativas foram feitas especificamente voltadas para o levantamento das espécies de Porifera, principalmente nas regiões costeiras. Tais ações fornecem atualmente aos pesquisadores iniciantes uma base de conhecimento bem mais abrangente do que a disponível na década anterior. Nos dez anos passados desde as últimas listagens feitas para o Estado de São Paulo, houve uma alteração significativa no quadro apresentado. Conforme pôde ser verificado neste trabalho, o período foi sem sombra de dúvida o mais prolífico no que se refere ao conhecimento da espongiofauna local. Palavras-chave: Porifera, biota paulista, Programa BIOTA/FAPESP.

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“…Although a growing number of studies investigated the cytotoxic, neurotoxic and antimicrobial activities of sponges from the Brazilian coast (Muricy et al, 1993;Rangel et al, 2001;Monks et al, 2002;Berlinck et al, 2004;Seleghim et al, 2007), most Brazilian sponges remain unstudied. The city of Rio de Janeiro harbours a sponge fauna distinct from that of other areas in Southeastern Brazil such as Arraial do Cabo and São Sebastião, were other screenings have been conducted (Monteiro & Muricy, 2004).…”

Section: Introductionmentioning

confidence: 99%

Antibiotic-resistant bacteria inhibited by extracts and fractions from Brazilian marine sponges

Marinho¹,

Muricy²,

Silva³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Bactérias resistentes a antibióticos inibidas por extratos e frações de esponjas marinhas do Brasil". O número crescente de bactérias resistentes aos antibióticos tem se tornado um sério problema médico nos últimos anos. As esponjas marinhas são uma fonte rica em compostos bioativos e muitas espécies podem ser úteis para o desenvolvimento de novos antimicrobianos. Esse estudo descreve uma triagem in vitro de esponjas para a pesquisa de novas substâncias contra bactérias resistentes. Os extratos de esponjas foram testados sobre 44 estirpes bacterianas, incluindo quatorze resistentes a antibióticos. Dez entre doze espécies de esponjas apresentaram atividade em um ou mais bioensaios. Os extratos aquosos de Cinachyrella sp. e Petromica citrina apresentaram um amplo espectro de ação sobre estirpes bacterianas resistentes, tais como, Staphylococcus aureus, Staphylococcus coagulase-negativos e Enterococcus faecalis. O extrato aquoso de P. citrina foi fracionado e a fração aquosa apresentou atividade inibitória sobre estirpes de Staphylococcus. Esta fração, na concentração do CMI (16 μg/mL), demonstrou efeito bactericida sobre células de S. aureus na fase exponencial de crescimento. O mecanismo de ação da fração ainda não foi elucidado, mas nós observamos que esta afeta a síntese protéica de Staphylococcus. Nossos resultados demonstraram pela primeira vez que Petromica citrina é uma fonte potencial de novas drogas para o tratamento de infecções causadas por bactérias resistentes. Unitermos: atividade antibacteriana, bactéria resistente a antibióticos, esponjas marinhas, Petromica citrina. ABSTRACT:The growing number of bacterial strains resistant to conventional antibiotics has become a serious medical problem in recent years. Marine sponges are a rich source of bioactive compounds, and many species can be useful for the development of new antimicrobial drugs. This study reports the in vitro screening of marine sponges in the search for novel substances against antibiotic-resistant bacteria. Sponge extracts were tested against 44 bacterial strains, including fourteen antibiotic-resistant strains. Ten out of the twelve sponge species studied showed activity in one or more of the bioassays. Aqueous extracts of Cinachyrella sp. and Petromica citrina showed a large action spectrum over resistant-bacteria such as Staphylococcus aureus, coagulase-negative staphylococci and Enterococcus faecalis. Aqueous extract of P. citrina was fractioned and aqueous fraction showed a greatest inhibitory activity on Staphylococcus strains. In addition, this fraction demonstrated a bactericidal effect on exponentially growing S. aureus cells at the MIC (16 µg/ mL). The mechanism of action of bioactive fraction is still unclear, but we showed that it affect protein biosynthesis of Staphylococcus. Our results demonstrated for the first time that P. citrina is a potential source of new drugs for the treatment of infections by antibiotic-resistant bacteria.

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Cytotoxic and neurotoxic activities in extracts of marine sponges (Porifera) from southeastern Brazilian coast

Cited by 36 publications

References 24 publications

Antibiotic, cytotoxic and enzyme inhibitory activity of crude extracts from Brazilian marine invertebrates

Antibiotic, cytotoxic and enzyme inhibitory activity of crude extracts from Brazilian marine invertebrates

Checklist de Porifera do Estado de São Paulo, Brasil

Antibiotic-resistant bacteria inhibited by extracts and fractions from Brazilian marine sponges

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