“…Frequency of karyorrhectic cells significantly correlated (τ = 0.259, p = 0.0193) with waterpipe exposure in the WPS group. Karyorrhexis as the occurrence of nuclear fragmentation, leads to the eventual disintegration of the nucleus [ 27 ] and presents a biomarker often increased in WPS compared to NS [ 67 ]. Nonsignificant positive correlation between other comet assay parameters as well as basal, condensed chromatin and pycnotic buccal cells, and WPS exposure indicates increase in DNA damage and cytotoxicity with intensified waterpipe smoking [ 67 ].…”