Cytotoxic and genotoxic effects of extracts fromAnnona montanaM. fruit

Bailón-Moscoso, Natalia; Romero-Benavides, Juan Carlos; Orellana, María Isabel Ramirez; Ojeda, Karla; Glenda, Granda; Ratoviski, Edward A.; Ostrosky‐Wegman, Patricia

doi:10.1080/09540105.2016.1148121

Cited by 19 publications

(11 citation statements)

References 34 publications

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“…The highest activity was observed for the ethyl acetate extract, with the following percentages of inhibition: lung cancer A549 (97 ± 1.7%), cerebral astrocytoma D384 (98 ± 3.2%), breast carcinoma MCF-7 (93 ± 4.5%), prostate cancer PC-3 (99 ± 6.8%), and colon cancer RKO (96 ± 5.7%). The IC 50 values were 9.6, 7.9, 6.0, 13.1, and 7.7 µg/mL, respectively, for each tumor cell line [15].…”

Section: Annonaceaementioning

confidence: 93%

Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

et al. 2021

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The use of plants as therapeutic agents is part of the traditional medicine that is practiced by many indigenous communities in Ecuador. The aim of this study was to update a review published in 2016 by including the studies that were carried out in the period 2016–July 2021 on about 120 Ecuadorian medicinal plants. Relevant data on raw extracts and isolated secondary metabolites were retrieved from different databases, resulting in 104 references. They included phytochemical and pharmacological studies on several non-volatile compounds, as well as the chemical composition of essential oils (EOs). The tested biological activities are also reported. The potential of Ecuadorian plants as sources of products for practical applications in different fields, as well the perspectives of future investigations, are discussed in the last part of the review.

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Section: Annonaceaementioning

confidence: 93%

Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

et al. 2021

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“…They are used as complementary medicine or to synthesize chemical compounds. According to the World Health Organization, more than 80% of the world's population depends on nature-derived traditional alternative medicine for their primary healthcare needs [16]. One of these plants with extensive traditional use is A. squamosa; however, biologically, it is less well characterized.…”

Section: Discussionmentioning

confidence: 99%

Selective Cytotoxic Effects of Annona Squamosa Leaves against Breast Cancer Cells via Apoptotic Signaling Proteins

Al-Nemari¹,

Bacha²,

Al-Senaidy³

et al. 2020

Preprint

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: Annona squamosa L. is an important medicinal plant used in traditional medicine for the treatment of various diseases. Different parts of A. squamosa L. have various therapeutic effects; however, the anticancer activity of the leaves has not yet been identified. In vitro, MTT, nuclear staining, and LDH assays were used to evaluate cell survival and proliferation in cells exposed to the extracts. The effect of the extracts on cell migration was investigated using a monolayer wound repair assay, and the apoptotic effects were evaluated using flow cytometry. A breast cancer model was used to study the effect of the extract on the tumor size, and the expression of different proliferative and apoptotic markers was evaluated by immunohistochemical analysis. At a concentration of 100 µg/mL, A. squamosa leaf extracts exerted strong antiproliferative and cytotoxic effects against various cell lines. The extracts reduced wound closure and strongly induced apoptosis. In vivo study, rats were sacrificed 24 h after the last injection, and tumor size, as well as the expression of proliferative and apoptotic markers, were observed to be greatly affected by treatment with the extracts. Therefore, A. squamosa leaf extract may be developed as a potential novel drug to treat breast cancer in the future

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“…In the present study, the genotoxic, mutagenicity, and cytotoxic effects of ethanolic extract of H. persicum were investigated in vitro assay using human lymphocyte. We used normal human lymphocyte, which commonly regarded as biological model for this aim (Natalia Bailon‐Moscoso et al, ). It is stated that the basic mechanisms of DNA damage are alike in various tissues, therefore recommending that the level of damage in lymphocytes may reflect those happening in other tissues (Silva Pereira et al, ).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity, genotoxicity, and mutagenicity potential of ethanolic extract of Heracleum persicum Desf. ex Fischer

Amani

Gandomi

Basti

et al. 2019

Journal of Food Safety

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Heracleum persicum is a traditional medicinal plant with several pharmaceutical and food applications. There is no well‐documented information regarding the safety profile of this plant. The aim of this study was to evaluate the genotoxic, mutagenic, and cytotoxic potential of ethanolic extract of H. persicum (EEHP). The EEHP induced DNA damage at concentrations higher than 0.25 mg/mL. DNA damage index of the EEHP at dose of 10 mg/mL was 25 times greater than that in negative control. A dose dependent increase was found in tail moment by increasing the concentration of the extract. No statistically significant difference was seen in revertant Salmonella typhimurium colonies, with or without S9, between sub‐inhibitory concentrations of EEHP and negative control (p < 0.05). The results of the MTT assay revealed that treatment by different concentrations of EEHP caused 60 to 100% reduction in cell viability. The survival of the lymphocytes was negatively affected by EEHP concentrations higher than 1 mg/mL as evaluated by trypan blue assay. The results of this study showed genotoxicity and cytotoxicity potential of EEHP on human lymphocytes, effect of the EEHP exhibited in this work, further studies are needed to decide about the mutagenicity hazard of this medicinal plant. Practical applications Heracleum persicum is used as flavoring agent and for miscellaneous remedial purposes in Iranian traditional medicine. These widespread applications are based on the public belief that this plant is efficient and safe due to its traditional usage for long centuries. Besides many pharmacological properties, there is low information about the safety profile of this plant. The results of this study showed that ethanolic extract of H. persicum (EEHP) caused DNA damage on human lymphocytes. Furthermore, cytotoxicity of the EEHP on human lymphocytes was seen. According to these results, it is worthwhile to raise consumer awareness that excessive consumption of food and pharmaceutical preparations containing high concentrations of this plant may pose a health risk.

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Cytotoxic and genotoxic effects of extracts fromAnnona montanaM. fruit

Cited by 19 publications

References 34 publications

Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

<strong>Selective Cytotoxic Effects of <em>Annona Squamosa Leaves </em>against Breast Cancer Cells via Apoptotic Signaling Proteins</strong>

Cytotoxicity, genotoxicity, and mutagenicity potential of ethanolic extract of Heracleum persicum Desf. ex Fischer

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