Cytotoxic and biomechanical effects of clinical dosing schemes of paclitaxel on neurons and cancer cells

Lin, Chou Ching K.; Yang, Chih Hsuan; Ju, Ming‐Shaung

doi:10.1007/s00280-020-04113-0

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…When it comes to cellular elasticity, the observed outcome can vary based on the aforementioned factors. For instance, Lin et al observed an interesting effect of paclitaxel on melanoma cells [ 65 ]. Paclitaxel works by blocking the mitotic cycle, leading to apoptosis.…”

Section: Current Results On Cell Stiffnessmentioning

confidence: 99%

Atomic Force Microscopy for the Study of Cell Mechanics in Pharmaceutics

Siboni,

Ruseska,

Zimmer

2024

Pharmaceutics

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Cell mechanics is gaining attraction in drug screening, but the applicable methods have not yet become part of the standardized norm. This review presents the current state of the art for atomic force microscopy, which is the most widely available method. The field is first motivated as a new way of tracking pharmaceutical effects, followed by a basic introduction targeted at pharmacists on how to measure cellular stiffness. The review then moves on to the current state of the knowledge in terms of experimental results and supplementary methods such as fluorescence microscopy that can give relevant additional information. Finally, rheological approaches as well as the theoretical interpretations are presented before ending on additional methods and outlooks.

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Section: Current Results On Cell Stiffnessmentioning

confidence: 99%

Atomic Force Microscopy for the Study of Cell Mechanics in Pharmaceutics

Siboni,

Ruseska,

Zimmer

2024

Pharmaceutics

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Stiffening of DU145 prostate cancer cells driven by actin filaments – microtubule crosstalk conferring resistance to microtubule-targeting drugs

et al. 2021

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Biomechanical Properties of Cancer Cells

Runel

Lopez-Ramirez

Chlasta³

et al. 2021

Cells

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Since the crucial role of the microenvironment has been highlighted, many studies have been focused on the role of biomechanics in cancer cell growth and the invasion of the surrounding environment. Despite the search in recent years for molecular biomarkers to try to classify and stratify cancers, much effort needs to be made to take account of morphological and nanomechanical parameters that could provide supplementary information concerning tissue complexity adaptation during cancer development. The biomechanical properties of cancer cells and their surrounding extracellular matrix have actually been proposed as promising biomarkers for cancer diagnosis and prognosis. The present review first describes the main methods used to study the mechanical properties of cancer cells. Then, we address the nanomechanical description of cultured cancer cells and the crucial role of the cytoskeleton for biomechanics linked with cell morphology. Finally, we depict how studying interaction of tumor cells with their surrounding microenvironment is crucial to integrating biomechanical properties in our understanding of tumor growth and local invasion.

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Cytotoxic and biomechanical effects of clinical dosing schemes of paclitaxel on neurons and cancer cells

Cited by 4 publications

References 24 publications

Atomic Force Microscopy for the Study of Cell Mechanics in Pharmaceutics

Atomic Force Microscopy for the Study of Cell Mechanics in Pharmaceutics

Stiffening of DU145 prostate cancer cells driven by actin filaments – microtubule crosstalk conferring resistance to microtubule-targeting drugs

Biomechanical Properties of Cancer Cells

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