Cytotoxic and apoptotic effects of constituents from Millettia pachycarpa Benth

Ye, Haoyu; Fu, Afu; Wu, Wenshuang; Li, Yanfang; Wang, Guangcheng; Tang, Minghai; Li, Shucai; He, Shikun; Zhong, Shijie; Lai, Huijun; Yang, Jianhong; Xiang, Minli; Peng, Aihua; Chen, Lijuan

doi:10.1016/j.fitote.2012.08.001

Cited by 51 publications

(49 citation statements)

References 38 publications

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“…Millepachine, a natural pyranochalcone, was for the first time isolated from Millettia pachycarpa in our lab [17]. It exhibited a potent cytotoxic activity and induced apoptosis effects in several human cancer cell lines with an IC 50 values ranging from 1.51 to 4.0 mM [18].…”

Section: Introductionmentioning

confidence: 97%

Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents

Dong

Han

Wang

et al. 2013

European Journal of Medicinal Chemistry

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Section: Introductionmentioning

confidence: 97%

Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents

Dong

Han

Wang

et al. 2013

European Journal of Medicinal Chemistry

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“…(Yankep et al, 2003;Ye et al, 2012). Croton heliotropiifolius Kunth is an endemic specie in the northeast of Brazil frequently found within "caatinga", "brejo", "resting" and "cerrado" vegetations.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical characteristics and cytotoxic effect of the methanolic extract of Croton heliotropiifolius Kunth (Euphorbiaceae)

Silva¹,

Silva²,

Silva³

et al. 2017

Afr. J. Pharm. Pharmacol.

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“…It is used as fish poison, pesticide, blood tonic and in the treatment of cancer and infertility traditionally in India and China [11,13,14]. Some of the compounds isolated from M. pachycarpa have been reported to be cytotoxic and induce apoptosis in HeLa cells [15]. Oroxylum indicum (family Bignoniaceae), sona patha is a deciduous tree distributed throughout Asia and grows at an altitude of 1200 m mainly in ravines, in damp region and moist places in the forests.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and TLC Profiling of Oroxylum indicum and Milletia pachycarpa

M¹,

J²

2015

Saha, J Plant Biochem Physiol

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The humans have used medicinal plants for healthcare since the time immemorial. The systematic phytochemical analysis of traditionally used medicinal plants is needed to establish their use as medicine. Oroxylum indicum and Milletia pachycarpa have been used in India and China to treat various health related disorders. Therefore it was decided to undertake phytochemical and Thin Layer Chromatography (TLC) profiling of different extracts of Oroxylum indicum and Milletia pachycarpa using standard procedures. The dried powder of stem bark of Oroxylum indicum and root bark of Milletia pachycarpa was sequentially extracted in chloroform, ethanol and water. The dried extract of each plant was phytochemically analyzed for the presence of alkaloids, flavonoids, cardiac glycosides, phytosterols, saponins, tannins steroids and phlobatannins. Each extract from both plants was processed for TLC profiling on silica gel using various solvent combinations as mobile phase. The phytochemical analysis showed the presence of alkaloids in chloroform and ethanol extracts, whereas alkaloids were absent in aqueous extract of both Oroxylum indicum and Milletia pachycarpa. The flavonoids were observed in all extracts of both plants. However, cardiac glycosides were absent in the aqueous extract of Milletia pachycarpa. The saponins were detected in all the extracts of both plants except the chloroform extract of Oroxylum indicum. The tannins could not be detected in the aqueous extract of M. pachycarpa. The phlobatannins were absent in all extracts of both plants. Steroids exhibiting a wide variety of biological activity [8]. Almost every part of this tree possesses medicinal properties and has been used in several traditional Ayurvedic and folk medicines [18]. O. Indicum has been reported to possess several medicinal properties including analgesic, antibacterial, anti-inflammatory, anticancer, antioxidant [19][20][21][22][23]. Therefore, an attempt has been made to study the phytochemical constituents of Milletia pachycarpa and Oroxylum indicum. Materials and Methods Preparation of the extractThe non-infected stem bark of O. indicum was collected from Champhai whereas root bark of Milletia pachycarpa was collected from Kolasib district of Mizoram, India during the dry season in the month of January. The identification of plant was done by the Department of Horticulture and Aromatic and Medicinal Plants, Mizoram University, Aizawl, India. The barks of both plants was washed thoroughly with clean water and allowed to shade dry at room temperature in the dark in clean and hygienic conditions. The dried barks of both plants were separately powdered using an electrical grinder at room temperature. The powdered bark of O. indicum stem or root bark of M. pachycarpa was sequentially extracted with petroleum ether, chloroform, ethanol and distilled water according to increase in polarity using a Soxhlet apparatus until the solvents became colourless [24]. The liquid extracts were concentrated by evaporating their liquid contents using ...

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Cytotoxic and apoptotic effects of constituents from Millettia pachycarpa Benth

Cited by 51 publications

References 38 publications

Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents

Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents

Physicochemical characteristics and cytotoxic effect of the methanolic extract of Croton heliotropiifolius Kunth (Euphorbiaceae)

Phytochemical and TLC Profiling of Oroxylum indicum and Milletia pachycarpa

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