Cytotoxic and Antiviral Compounds from Bryophytes and Inedible Fungi

Abstract

Over several hundred new compounds have been isolated from the bryophytes and more than 40 new carbon skeletal terpenoids and aromatic compounds found in this class. Most of liverworts elaborate characteristic odiferous, pungent and bitter tasting compounds many of which show, antimicrobial, antifungal, antiviral, allergenic contact dermatitis, cytotoxic, insecticidal, anti-HIV, superoxide anion radical release, plant growth regulatory, neurotrophic, NO production inhibitory, muscle relaxing, antiobesity, piscicidal and nematocidal activity. Several inedible mushrooms produce spider female pheromones, strong antioxidant, or cytotoxic compounds. The present paper concerns with the isolation of terpenoids, aromatic compounds and acetogenins from several bryophytes and inedible fungi and their cytotoxic and antiviral activity.

Brachythecium rutabulum, A Neglected Medicinal Moss

“…Since Galen’s first century works listed mostly Italian medicinal plants, these books enabled local inhabitants, including pharmacists and physicians, to harvest medicinal raw materials locally (Cooper 2010 ). Historical medical applications of some species bryophytes listed in these catalogues correspond with today’s pharmacological knowledge of the herb (Asakawa 2007 ; Asakawa et al 2013 ; Drobnik and Stebel 2014 , 2015 , 2017 ).…”

Four Centuries of Medicinal Mosses and Liverworts in European Ethnopharmacy and Scientific Pharmacy: A Review

“…Historical ethnobiological and ethnopharmaceutical uses of bryophytes are sometimes convergent with our contemporary knowledge, e.g., in the case of many bryophytes used externally which prove to be antimicrobial [ 28 , 29 , 31 ]. However, the greatest number of biochemical and pharmacological reports on European bryophytes concern Marchantia polymorpha [ 28 , 30 , 31 , 46 ].…”

“…Having identified the species mentioned in the original texts, their historical medicinal applications were interpreted and cross-checked with ethnopharmacological monographs (especially [ 5 ] and [ 28 ]), as well as the most recent data on their chemical components and pharmacology by [ 28 , 29 , 30 , 31 , 32 ].…”

Türk Soluk Ciğerotu (Chiloscyphus polyanthos (L.) Corda)’nun İnsan Periferal Kan Lenfositlerine Karşı Sitotoksik ve Genotoksik Aktivitesi

“…The bryophytes have been investigated pharmaceutically for active biomolecules. Several constituents with therapeutic potential have been isolated, characterized and investigated for anti-bacterial, anti-fungal, anti-viral, anti-oxidative, antiinflammatory, anti-tumoral and anti-cancer activity (Saxena and Harinder, 2004;Çolak et al, 2011;Dey and De, 2012;Asakawa et al, 2013a;Chandra et al, 2017). The bryophytes are placed taxonomically between algae and pteridophytes; there are about 24000 species in the world.…”