Cytotoxic and Antitumor Activity of Momilactone B from Rice Hulls

Kim, Sun-Jung; Park, Hae-Ryong; Park, Eunju; Lee, Seung‐Cheol

doi:10.1021/jf062020b

Cited by 75 publications

(62 citation statements)

References 18 publications

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“…In previous research, the quantification of momilactones A and B was reported using HPLC (Lee et al 1999;Shimura et al 2007;Lee et al 2002;Kong et al 2004;Kim et al 2007;Kato-Noguchi and Ota 2013). However, their contents can also be determined by GC-MS, which have been noted in in several reports (Matsuyama 1983;Fukuta et al 2007;Kodama et al 1988), as well as in this study, using standard momilactones A and B to compare their retention times, mass spectra, and fragments.…”

Section: Contents Of Momilactones a And Bsupporting

confidence: 51%

“…Since momilactones A and B were first discovered by Kato et al (1973), major research has been conducted on the two compounds concentrated on plant growth and pathogen (Fukuta et al 2007;Okada et al 2007;Hasegawa et al 2010), and antioxidant capacity (Fukuta et al 2007), cytotoxic and antitumor activity (Kim et al 2007), whereas other biological activities of momilactones A and B have remained unknown. This study is the first to demonstrate that momilactones A and B correlated to the tolerance of drought and salinity in much stronger levels than the weed tolerance in rice.…”

Section: Correlation Coefficientsmentioning

confidence: 99%

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Allelopathic momilactones A and B are implied in rice drought and salinity tolerance, not weed resistance

Xuan

Minh

Anh

et al. 2016

Agron. Sustain. Dev.

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Momilactones A and B are allopathic phytoalexins that are involved in weed resistance of rice. There is little knowledge on the roles of momilactones A and B on drought and salinity tolerance. Here we analyzed the contents of momilactones A and B in 30 rice cultivars of various origins including hybrid, foreign, sticky, local, upland sticky, and upland rice of the two subtypes Indica and Japonica. Momilactone contents were compared with salinity tolerance, drought tolerance, weed resistance, total flavonoids, total phenols, and antioxidant capacity. Results show that, contrary to the current knowledge, momilactones A and B have very low correlation with weed resistance, with r coefficients of 0.001 and 0.09, respectively. Correlation was higher with drought tolerance, of 0.65 for momilactones A and 0.27 for momilactones B. Overall we conclude that the development of bioactive reagents derived from momilactones A and B is more potent to reduce salinity and drought stresses than weed tolerance in rice.

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Section: Contents Of Momilactones a And Bsupporting

confidence: 51%

Section: Correlation Coefficientsmentioning

confidence: 99%

Allelopathic momilactones A and B are implied in rice drought and salinity tolerance, not weed resistance

Xuan

Minh

Anh

et al. 2016

Agron. Sustain. Dev.

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“…Joung et al [72] 2008 Momilactone B (rice husk) Suppressed hypoxia-induced increases in phospho-STAT5, STAT5b, cyclin D1, and cdk4 protein levels in human breast cancer cells.…”

Section: Licheniformis)mentioning

confidence: 99%

By-products of Rice Processing: An Overview of Health Benefits and Applications

Esa¹,

Ling²

2016

J Rice Res

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Our study was centred on the increasing literature associated with rice by-products and main components, especially those intended to combat cancer, improve plasma lipid levels or control the blood glucose levels. Rice byproducts, such as rice straw, rice husks, rice bran, rice germ and broken rice, are extensively abundant agricultural wastes from the rice industry, and the percentage of their production depends on the milling rate and type of rice. Among all rice by-products, rice bran has been extensively studied.It contains phytochemicals such as γ-oryzanol, vitamin E, mainly tocotrienols and dietary fibre. This paper reviews the existing literature on the potential role of rice by-products, focusing not only on the role of rice bran but also on the roles of other rice by-products, such as rice germ and rice husk, in the management of the diseases, investigating their various potential uses in the food industry and all possible properties that may contribute to these effects.

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“…Although this compound has been studied as an allelochemical of rice (14,15), several reports have revealed that momilactone B exhibits several biological activities as a potential herbicidal agent (16,17). More recently, momilactone B has been shown to be a novel potential chemotherapeutic agent to induce apoptosis in solid human tumors and blood cancer cells (18,19). However, the anticancer effects of momilactone B have not been well investigated.…”

Section: Introductionmentioning

confidence: 99%

Momilactone B induces apoptosis and G1 arrest of the cell cycle in human monocytic leukemia U937 cells through downregulation of pRB phosphorylation and induction of the cyclin-dependent kinase inhibitor p21Waf1/Cip1

Park¹,

Jeong²,

Kim³

et al. 2014

Oncology Reports

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Abstract. Momilactone B, a terpenoid phytoalexin present in rice bran, has been shown to exhibit several biological activities. The present study was conducted using cultured human leukemia U937 cells to elucidate the possible mechanisms by which momilactone B exerts its anticancer activity, which to date has remained poorly understood. Momilactone B treatment of U937 cells resulted in a dose-dependent inhibition of cell growth and induced apoptotic cell death as detected by chromatin condensation, DNA fragmentation, the cleavage of poly(ADP-ribose) polymerase and Annexin V-FITC staining. Flow cytometric analysis revealed that momilactone B resulted in G1 arrest in cell cycle progression, which was associated with the dephosphorylation of retinoblastoma protein (pRB) and enhanced binding of pRB with the E2F transcription factor family proteins. Treatment with momilactone B also increased the expression of cyclin-dependent kinase (Cdk) inhibitor p21Waf1/Cip1 in a p53-independent manner, without any noticeable changes in G1 cyclins and cyclin-dependent kinases (Cdks), except a slight decrease in cyclin E. Moreover, in vitro kinase assay indicated that momilactone B significantly decreased Cdk4-and Cdk6-associated kinase activities through a notably increased binding of p21 to Cdk4 and Cdk6. Our results demonstrated that momilactone B caused G1 cell cycle arrest and apoptosis in U937 cells through the induction of p21 expression, inhibition of Cdk/cyclin-associated kinase activities, and reduced phosphorylation of pRB, which may be related to anticancer activity. IntroductionImpaired deregulated cell cycle progression and induction of apoptosis are the primary characteristics of cancer cells due to an imbalance between proliferation and cell death. In terms of cell cycle regulation, the cyclin-dependent kinases (Cdks) are the key regulators of eukaryotic cell cycle progression in cooperation with various endogenous cyclins and Cdks (1,2). An alteration in the cooperation may lead to increased or decreased cell growth and proliferation followed by differentiation and/or cell death by apoptosis (3,4). Therefore, the key regulators of cell cycle progression and apoptotic induction may be important molecular targets for therapeutic intervention, and inhibition of cell cycle regulation may be particularly useful in the treatment of diseases caused by uncontrolled cell proliferation, such as cancer.In general, passage through G1 into the S phase is regulated by the activities of D-type cyclin-and cyclin E-associated Cdks. D-type cyclins bind to existing Cdk4 and Cdk6, forming active complexes. The complexes in turn phosphorylate the retinoblastoma susceptibility protein (pRB). The hyperphosphorylated pRB dissociates from the E2F/DP1/pRB Momilactone B induces apoptosis and G1 arrest of the cell cycle in human monocytic leukemia U937 cells through downregulation of pRB phosphorylation and induction of the cyclin-dependent kinase inhibitor p21Waf1/Cip1

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Cytotoxic and Antitumor Activity of Momilactone B from Rice Hulls

Cited by 75 publications

References 18 publications

Allelopathic momilactones A and B are implied in rice drought and salinity tolerance, not weed resistance

Allelopathic momilactones A and B are implied in rice drought and salinity tolerance, not weed resistance

By-products of Rice Processing: An Overview of Health Benefits and Applications

Momilactone B induces apoptosis and G1 arrest of the cell cycle in human monocytic leukemia U937 cells through downregulation of pRB phosphorylation and induction of the cyclin-dependent kinase inhibitor p21Waf1/Cip1

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