Cytotoxic and antiproliferative effects of evernic acid on HeLa cell lines: A candidate anticancer drug

Kızıl, Hamit Emre; Ağar, Güleray; Anar, Mustafa

doi:10.1016/j.jbiotec.2014.07.098

Cited by 8 publications

(8 citation statements)

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“…At a concentration of 100 µg/ml, squamatic and thamnolic acids ( 2 and 3 ) induced the lowest growth inhibition (about 44 versus > 70% for the other selected compounds), while evernic acid (1) is highly cytotoxic. These results are in accordance with a previous study ( Kizil et al., 2014 ). Furthermore, according to Shcherbakova et al.…”

Section: Resultssupporting

confidence: 94%

Lichen Polyphenolic Compounds for the Eradication of Candida albicans Biofilms

Girardot

Millot

Hamion

et al. 2021

Front. Cell. Infect. Microbiol.

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Lichens, due to their symbiotic nature (association between fungi and algae), constitute a chemical factory of original compounds. Polyphenolic compounds (depsides and depsidones) are the main constituents of lichens and are exclusively biosynthesized by these organisms. A panel of 11 polyphenols was evaluated for their anti-biofilm activity against Candida albicans biofilms on the maturation phase (anti-maturation) (MMIC50) as well as on preformed 24-h-old biofilm (anti-biofilm) (MBIC50) using the XTT assay. Minimum inhibitory concentrations of compounds (MICs) against C. albicans planktonic yeast were also determined using a broth microdilution method. While none of the tested compounds were active against planktonic cells (IC50 > 100 µg/ml), three depsides slowed the biofilm maturation (MMIC50 ≤12.5 µg/ml after 48 h of contact with Candida cells). Evernic acid was able to both slow the maturation and reduce the already formed biofilms with MBIC50 ≤12.5 µg/ml after 48 h of contact with the biofilm. This compound shows a weak toxicity against HeLa cells (22%) at the minimal active concentration and no hemolytic activity at 100 µg/ml. Microscopic observations of evernic acid and optimization of its solubility were performed to further study this compound. This work confirmed the anti-biofilm potential of depsides, especially evernic acid, and allows to establish the structure–activity relationships to better explain the anti-biofilm potential of these compounds.

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Section: Resultssupporting

confidence: 94%

Lichen Polyphenolic Compounds for the Eradication of Candida albicans Biofilms

Girardot

Millot

Hamion

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Another study showed that EA extracted from Ramalina fastigiata has antioxidant capacity and an antimicrobial effect on E. coli [ 16 ]. Others reported EA inhibits the proliferations of U-87 human glioblastoma cells and HeLa cells (a cervical cancer cell line) [ 17 , 18 ]. However, only one study has reported that it has a protective effect on U373-MG glioblastoma and SH-SY5Y neuroblastoma cells [ 13 ], and to date, no report has been issued on its neuroprotective effects in the presence of the neurodegenerative disease.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective and Anti-Inflammatory Effects of Evernic Acid in an MPTP-Induced Parkinson’s Disease Model

Lee

Suh

Yang

et al. 2021

IJMS

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Oxidative stress, mitochondrial dysfunction, and neuroinflammation are strongly associated with the pathogenesis of Parkinson’s disease (PD), which suggests that anti-oxidative and anti-inflammatory compounds might provide an alternative treatment for PD. Here, we evaluated the neuroprotective effects of evernic aid (EA), which was screened from a lichen library provided by the Korean Lichen Research Institute at Sunchon National University. EA is a secondary metabolite generated by lichens, including Ramalina, Evernia, and Hypogymnia, and several studies have described its anticancer, antifungal, and antimicrobial effects. However, the neuroprotective effects of EA have not been studied. We found that EA protected primary cultured neurons against 1-methyl-4-phenylpyridium (MPP+)-induced cell death, mitochondrial dysfunction, and oxidative stress, and effectively reduced MPP+-induced astroglial activation by inhibiting the NF-κB pathway. In vivo, EA ameliorated MPTP-induced motor dysfunction, dopaminergic neuronal loss, and neuroinflammation in the nigrostriatal pathway in C57BL/6 mice. Taken together, our findings demonstrate that EA has neuroprotective and anti-inflammatory effects in PD models and suggest that EA is a potential therapeutic candidate for PD.

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“…It has been shown that ATR together with lecanoric and evernic acid reduce viability of tested cell lines (HCT-116, HEK293T, HeLa, NIH3T3, RAW246.7) in a cell line-dependent manner, with lecanoric acid being the most effective [12]. The antitumor activity of evernic acid against HeLa cancer cell line has also been reported [40].…”

Section: Anticancer Activity Of Lichen Secondary Metabolitesmentioning

confidence: 92%

Uncovering the Anticancer Potential of Lichen Secondary Metabolites

Simko

Kisková

2022

J. Anal. Oncol.

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Lichens produce a plethora of primary and secondary metabolites. Secondary metabolites have several biological functions that can be used for human health. Recent studies have described their antioxidant, anti-inflammatory, antimycotic, and antibiotic/antiviral activities. However, attention has mainly been focused on their antiproliferative, cytotoxic, and anticancer effects. Because there are many publications describing the molecular mechanisms leading to the anticancer effects of lichen secondary metabolites, the aim of this review is to summarize results from current research with the main emphasis on atranorin, usnic and gyrophoric acid.

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Cytotoxic and antiproliferative effects of evernic acid on HeLa cell lines: A candidate anticancer drug

Cited by 8 publications

References 0 publications

Lichen Polyphenolic Compounds for the Eradication of Candida albicans Biofilms

Lichen Polyphenolic Compounds for the Eradication of Candida albicans Biofilms

Neuroprotective and Anti-Inflammatory Effects of Evernic Acid in an MPTP-Induced Parkinson’s Disease Model

Uncovering the Anticancer Potential of Lichen Secondary Metabolites

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