Cytotoxic and antiproliferative constituents fromDictyota ciliolata, Padina sanctae-crucisandTurbinaria tricostata

Caamal-Fuentes, Edgar; Moo-Puc, Rosa; Freile‐Pelegrín, Yolanda; Robledo, Daniel

doi:10.3109/13880209.2014.886273

Cited by 34 publications

(26 citation statements)

References 20 publications

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“…Pech-Puch et al reported in 2019 the isolation and structural characterization of seven terpenoids from the sponge Spongia tubulifera (now S. (Spongia) tubulifera) that were collected at Rio Indio, Quintana Roo state. Two of them resulted in being new natural products, 3β-hydroxyspongia-13(16),14-dien-2-one (15) and 19-dehydroxy-spongian diterpene 17 (16), while the remaining five corresponded to previously reported terpenes, three spongia furanoditerpenes: 9-nor-3-hydroxyspongia-3,13(16)14-trien-2-one (17), 3β, 19 dihydroxyspongia-13(16),14-dien-2-one (epispongiadiol) (18), and spongian diterpene 17 (19); the furanoditerpene ambliol C (20) and the sesterterpene scalarin (21). The pharmacological analysis of the isolated compounds displayed a very mild cytotoxic activity for 15, 18, and 20, while they showed no antimicrobial (Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus) or antiviral (HAdV5 and HAdV5-GFP) activities [16] (Figure 4).…”

Section: Diterpenes and Sesterterpenesmentioning

confidence: 87%

Marine Natural Products from the Yucatan Peninsula

et al. 2020

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Mexico is one of the three areas of the world with the greatest terrestrial and cultural biological diversity. The diversity of Mexican medicinal flora has been studied for a long time and several bioactive compounds have been isolated. The investigation of marine resources, and particularly the potential of Mexican marine resources, has not been intensively investigated, even though the Yucatan Peninsula occupies 17.4% of the total of the Mexican coast, with great biological diversity in its coasts and the ocean. There are very few studies on the chemistry of natural products from marine organisms that were collected along the coasts of the Yucatan Peninsula and most of them are limited to the evaluation of the biological activity of their organic extracts. The investigations carried out on marine species from the Yucatan Peninsula resulted in the identification of a wide structural variety of natural products that include polyketides, terpenoids, nitrogen compounds, and biopolymers with cytotoxic, antibacterial, antifouling, and neurotoxic activities. This review describes the literature of bioprospecting and the exploration of the natural product diversity of marine organisms from the coasts of the Yucatan Peninsula up to mid-2019.

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Section: Diterpenes and Sesterterpenesmentioning

confidence: 87%

Marine Natural Products from the Yucatan Peninsula

et al. 2020

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“…Caamal‐Fuentes et al reported that the hexane extracts of Dictyota ciliolata Sonder ex Kützing (Dictyotaceae), Padina sanctae‐crucis Børgesen (Dictyotaceae), and Turbinaria tricostata E.S. Barton (Sargassaceae) exhibit cytotoxic and antiproliferative activities; however, the compounds responsible for these activities have not yet been identified. Fucosterol and vinylcholesterol were found to be bioactive components of the hexane extracts of T. tricostata and P. sanctae‐crucis , with a CC 50 value of approximately 3.1–25.6 µg mL −1 on the cell lines tested.…”

Section: Biological Effects Of Fucosterolmentioning

confidence: 99%

Health benefit of fucosterol from marine algae: a review

et al. 2016

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Seaweeds belong to a group of marine plants known as algae, which are consumed as sea vegetables in several Asian countries. Recent studies have focused on the biological and pharmacological activities of seaweeds and their highly bioactive secondary metabolites because of their potential in the development of new pharmaceutical agents. Although several varieties of bioactive novel compounds such as phlorotannins, diterpenes and polysaccharides from seaweeds have already been well scrutinized, fucosterol as a phytosterol still needs to reinvent itself. Fucosterol (24-ethylidene cholesterol) is a sterol that can be isolated from algae, seaweed and diatoms. Fucosterol exhibits various biological therapeutics, including anticancer, antidiabetic, antioxidant, hepatoprotective, antihyperlipidemic, antifungal, antihistaminic, anticholinergic, antiadipogenic, antiphotodamaging, anti-osteoporotic, blood cholesterol reducing, blood vessel thrombosis preventive and butyrylcholinesterase inhibitory activities. In this review, we address some potential approaches for arbitrating novel fucosterol biologics in the medical field, focusing on the selection of personalized drug candidates and highlighting the challenges and opportunities regarding medical breakthroughs. We also highlight recent advances made in the design of this novel compound, as the significant health benefits from using these optimized applications apply to the nutraceutical and pharmaceutical fields.

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“…These two component shows anti proliferative effects on different cancer cell lines [54]. Other reports indicate that dichloromethane and ethyl sp.…”

Section: Solieriamentioning

confidence: 99%

“…U937 HL-60 cells [24] Ecklonia cava A2780, SKOV3 [47][48][49][50][51] Laminaria sp Colon , HeLa, colon Ht-29, HTLV [52,53] Padina sp KB, Hep-2, MCF-7, and SiHa [54] Sargassum sp Hela, MDA MB 231. Dalton's Ascitic lymphoma, HepG2, HT-29, Ca co-2, T47D, MDA-MB468 and /NIH 313, [55][56][57][58][59][60] Stypopodium sp SH-SY5Y, RBL-2H3, (Raw267), (V79), Caco-2.…”

Section: Solieriamentioning

confidence: 99%

Algae as potential repository of anti cancerous natural compounds

Mridha¹,

Paul²

2017

ijpm

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Algae constitute a promising source of novel compounds with potential as human therapeutic agents. In particular, algae have been considered as a potential source of new bio-active compound. Algae possess several biological activities, including anticancer activity. This review provides a comprehensive report on the several genera of algae belonging to Chlorophyceae, Pheophyceae and Rhodophyceae having anti-proliferative, apoptotic, anti angiogenic as well as cytotoxic efficacy and their mode of action in vitro as well as in vivo condition. Algae are extensively used as functional foods and medicinal herbs, and have a long history of use in Asian countries. Many algae have been used for the treatment of cancer, many crude or partially purified polysaccharides from various brown, green, and red algae have been tested for their antitumor activities. Relevant information was collected from scientific journals, books, and reports via library and electronic search using Medline, Pubmed, Science Direct, and Scopus. The different extracts with some other solvent shows a huge anti-proliferative action on different cancer as well as on different leukemia cell lines. Here we focus on several bioactive compounds that have been derived as well as characterized from different genera of algae and there mechanism of inhibiting cancer cell growth. Considering the ability of the golden treasure present in algae to act against different cancers, this review highlights the potential use of algae as anticancer agents.

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Cytotoxic and antiproliferative constituents fromDictyota ciliolata, Padina sanctae-crucisandTurbinaria tricostata

Abstract: This study is the first investigation on the bioactive components of D. ciliolata, P. sanctae-crucis, and T. tricostata. Although compounds 1-3 were described previously, the pharmacological activity of compound 4 is presented here for the first time.

Cited by 34 publications

References 20 publications

Marine Natural Products from the Yucatan Peninsula

Marine Natural Products from the Yucatan Peninsula

Health benefit of fucosterol from marine algae: a review

Algae as potential repository of anti cancerous natural compounds

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