Cytotoxic and antioxidant properties of selected<i>Scutellaria</i>species from the Western Ghats of Peninsular India

Salini, Sasidharan; Chubicka, Thomas; Sasidharan, N.; Sindhu, Edakkadath Raghavan; Babu, T. Ramesh

doi:10.3109/13880209.2012.715170

Cited by 10 publications

(3 citation statements)

References 22 publications

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“…The lymphatic cells are able to overcrowd, invade, and destroy lymphoid tissues and metastasize to other organs. Several studies have demonstrated that S. baicalensis , baicalin and baicalein display antiproliferative and apoptotic effects against lymphoma [17,54,55]. Huang et al reported that baicalin is capable of suppressing the growth of CA46 Burkitt lymphoma cells via induction of apoptosis with an IC 50 value of 10 μM [56].…”

Section: 5 Lymphomamentioning

confidence: 99%

Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies

et al. 2014

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Despite tremendous advances in the targeted therapy for various types of hematological malignancies with successful improvements in the survival rates, emerging resistance issues are startlingly high and novel therapeutic strategies are urgently needed. In addition, chemoprevention is currently becoming an elusive goal. Plant-derived natural products have garnered considerable attention in recent years due to the potential dual functions as chemotherapeutics and dietary chemoprevention. One of the particularly ubiquitous families is the polyphenolic flavonoids. Among them, baicalin and its aglycone baicalein have been widely investigated in hematological malignancies because both of them exhibit remarkable pharmacological properties. This review focuses on the recent achievements in drug discovery research associated with baicalin and baicalein for hematological malignancy therapies. The promising anticancer activities of these two flavonoids targeting diverse signaling pathways and their potential biological mechanisms in different types of hematological malignancies, as well as the combination strategy with baicalin or baicalein as chemotherapeutic adjuvants for recent therapies in these intractable diseases are discussed. Meanwhile, the biotransformation of baicalin and baicalein and the relevant approaches to improve their bioavailability are also summarized.

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Section: 5 Lymphomamentioning

confidence: 99%

Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies

et al. 2014

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“…7 This reaction depends on pH (optimum pH was 3.6). 8 FRAP methods performed at acidic pH conditions (3.6) for an iron solubility and the most important is to facilitate the transfer of …”

Section: Resultsmentioning

confidence: 99%

Antioxidant Activity and Lipoxygenase Enzyme Inhibitory Assay with Total Flavonoids Content from Garcinia hombroniana Pierre Stem Bark Extract

Listiyani

Elya²,

Puspitasari

2017

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Introduction: Garcinia has been known as a rich source of xanthones, flavonoids, and phenols. The aim of this research is to obtain data of antioxidant activity and to observe potential inhibition of lipoxygenase activity that most active from methanolic, ethyl acetate and n-hexane extracts with total flavonoids content from most active extracts from the bark of Garcinia hombroniana Pierre. Methods: The antioxidant activity was measured using the ferric reducing antioxidant power (FRAP), the anti-inflammatory assay was measured using inhibition of lipoxygenase activity test, qualitative analysis of flavonoids using thin layer chromatography, and total flavonoids content was measured using AlCl 3 colorimetric method. Results: The results showed that the ethyl acetate extract from G. hombroniana Pierre stem bark as the most active extract for antioxidant and lipoxygenase inhibition activity with EC 50 and IC 50 value consecutively 15.34 µg /ml; 0.26 µg /ml. Total flavonoids content of ethyl acetate is 7.430 mg QE/g extract. The results of this study showed bark extract Garcinia hombroniana Pierre has antioxidant activity and potent to inhibit lipoxygenase activity. Conclusion: Based on the research for methanolic, ethyl acetate and n-hexane extract, it can be concluded that the ethyl acetate extract of G. hombroniana Pierre as the most active extract for antioxidant and lipoxygenase inhibition activity.

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“…BL is used as a phytochemical marker for the quality control of Radix scutellariae in the Chinese pharmacopoeia, WL, B, W and OA are also major avonoids. It have been reported that they have anti-inammatory, 4,5 antioxidative, 6,7 antiallergic, 8 antiviral, 9 antigenotoxic, 10 anxiolytic 11 and anti-carcinogenic activities, 12,13 and have become the subjects of intense research interest. Kim et al have investigated the pharmacokinetic proles of BL, B, W and OA in rats aer intravenous administration of Scutellariae radix extract using LC-MS/MS.…”

Section: Introductionmentioning

confidence: 99%

Comparative pharmacokinetic and tissue distribution study of baicalin, baicalein, wogonoside, wogonin and oroxylin-A after oral administration of Component compatibility of SHT and total flavonoids fractions of Radix scutellariae to rats

Feng

Yao

et al. 2014

Anal. Methods

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Cytotoxic and antioxidant properties of selectedScutellariaspecies from the Western Ghats of Peninsular India

Abstract: Scutellaria species of Western Ghats showed cytotoxic and antioxidant potential and the presence of baicalein. This suggests that S. colebrookiana and S. violacea could be used as alternative sources for baicalein in view of the reported scarcity of S. baicalensis.

Cited by 10 publications

References 22 publications

Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies

Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies

Antioxidant Activity and Lipoxygenase Enzyme Inhibitory Assay with Total Flavonoids Content from Garcinia hombroniana Pierre Stem Bark Extract

Comparative pharmacokinetic and tissue distribution study of baicalin, baicalein, wogonoside, wogonin and oroxylin-A after oral administration of Component compatibility of SHT and total flavonoids fractions of Radix scutellariae to rats

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