Cytotoxic and antioxidant activities of flavonoids and diterpenoids from Macaranga involucrata (Roxb.) Baill

Abstract

Two flavonols, macagigantin (1) and brussoflavonol E (2), and two diterpenoids, deheiculatin C (3) and poilaneic acid (4), were obtained from Macaranga involucrata (Roxb.) Baill. leaves. Their structures were fully detailed on highresolution electrospray mass spectra, 1D NMR ( 1 H, 13 C), and 2D NMR (heteronuclear multiple quantum coherence, heteronuclear multiple bond coherence) spectra. The cytotoxic and antioxidant activities of compounds 1-4 were evaluated in murine leukemia cancer cells (P-388) and DPPH radical assays, respectively. Compounds 1-3 showed moderate activity against P-388 cells with IC 50 values of 26.3, 12.8, and 21.2 μM, respectively. Compounds 1-2 showed high activity against DPPH radical with IC 50 values of 332.1 and 125.6 μM, respectively.