Cytotoxic and anti-kinetoplastid potential of the essential oil of Alpinia speciosa K. Schum

Pereira, Pedro Silvino; Maia, Ana Josicleide; Duarte, Antônia Eliene; Oliveira-Tintino, Cícera Datiane Morais; Tintino, Saulo Relison; Barros, Luiz Marivando; Vega-Gomez, Maria C.; Rolón, Míriam; Coronel, Cathia; Coutinho, Henrique Douglas Melo; Silva, Teresinha G. da

doi:10.1016/j.fct.2018.01.024

Cited by 21 publications

(13 citation statements)

References 45 publications

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“…There have been several studies reported in the literature, supporting the suggestion that certain EOs from various plant species can demonstrate antiparasitic activity [22,23,24,25]. As has been demonstrated in the present study, the EO from P. matricarioides inhibited the growth of all tested parasites, with IC 50 ranging from 2 to 57 µg/mL.…”

Section: Discussionsupporting

confidence: 90%

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Chemical Composition, Antimicrobial and Antiparasitic Screening of the Essential Oil from Phania matricarioides (Spreng.) Griseb.

Gutiérrez

Scull

Villa³

et al. 2019

Molecules

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Essential oils (EOs) have gained increasing attention due to their pharmacological effectiveness, and they also constitute some of the most popular natural products. In this study, we present the chemical characterization of the EO from Phania matricarioides and the in vitro activity/selectivity against a wide panel of bacteria, fungi and parasitic protozoa. Forty-five compounds were identified in the studied EO, of which lavandulyl acetate (40.1%) and thymyl isobutyrate (13.9%) were the major components. The EO did not inhibit bacterial or fungal growth at the maximum concentration tested (64 µg/mL), although it displayed activity on all evaluated protozoa (IC50 values ranging from 2.2 to 56.6 µg/mL). In parallel, the EO demonstrated a noteworthy cytotoxic activity against peritoneal macrophages (CC50 values of 28.0 µg/mL). The most sensitive microorganism was Trypanosoma cruzi, which had a superior activity (IC50 = 2.2 µg/mL) and selectivity (SI = 13) in respect to other parasitic protozoa and the reference drug (p < 0.05). Further in vivo studies are needed to evaluate the potential use of this EO and the main compounds as antitrypanosomal agents. To our knowledge, this is the first report of chemical characterization and antimicrobial assessment of the EO from P. matricarioides.

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Section: Discussionsupporting

confidence: 90%

“…In this sense, one approach to the development process of new antitrypanosomal drugs has been the search of natural products [34]. In particular, several EOs from plants, such as Alpinia speciosa K. Schum [25], Lippia alba N.E.Br. ex Britton & P. Wilson [35], Piper tuberculatum Jacq.…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition, Antimicrobial and Antiparasitic Screening of the Essential Oil from Phania matricarioides (Spreng.) Griseb.

Gutiérrez

Scull

Villa³

et al. 2019

Molecules

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“…Vegetables have been the object of study and biological screening as an alternative for the treatment of neglected parasitic diseases [ 46 , 47 ]. Phytochemicals are currently being synthesized and chemically modified to ensure greater potency against these human pathogens [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

et al. 2021

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The species Cordia verbenacea DC (Boraginaceae), known as the whaling herb and camaradinha, is a perennial shrub species native to the Atlantic Forest. Its leaves are used in folk medicine as an anti-inflammatory, analgesic, antiulcerogenic and curative agent, in the form of teas or infusions for internal or topical use. The present study aimed to verify the cytotoxicity of the essential oil and the leishmanicidal and trypanocidal potential of C. verbenacea. The essential oil was characterized by GC-MS. The in vitro biological activity was determined by anti-Leishmania and anti-Trypanosoma assays. The cytotoxixity was determined using mammalian fibroblasts. The C. verbenacea species presented α-pinene (45.71%), β-caryophyllene (18.77%), tricyclo[2,2,1-(2.6)]heptane (12.56%) as their main compounds. The essential oil exhibited strong cytotoxicity at concentrations below 250 μg/mL (LC50 138.1 μg/mL) in mammalian fibroblasts. The potent anti-trypanosome and anti-promastigote activities occurred from the concentration of 62.5 μg/mL and was considered clinically relevant. The results also demonstrate that at low concentrations (<62.5 μg/mL), the essential oil of C. verbenacea managed to be lethal for these activities. This can be considered an indication of the power used in daily human consumption. Therefore, it can be concluded that the essential oil of C. verbenacea contains a compound with remarkable antiparasitic activities and requires further research.

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“…In similar tests with the same cell line, observed in the literature, concentrations <100% demonstrated similar behavior and were generally null [ 26 , 27 ]; therefore, we used higher concentrations, so that we visualized well-defined behavior characteristics of a dose-dependent response [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

A Potential New Source of Therapeutic Agents for the Treatment of Mucocutaneous Leishmaniasis: The Essential Oil of Rhaphiodon echinus

et al. 2022

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Weeds are an important source of natural products; with promising biological activity. This study investigated the anti-kinetoplastida potential (in vitro) to evaluate the cytotoxicity (in vitro) and antioxidant capacity of the essential oil of Rhaphiodon echinus (EORe), which is an infesting plant species. The essential oil was analyzed by GC/MS. The antioxidant capacity was evaluated by reduction of the DPPH radical and Fe3+ ion. The clone Trypanosoma cruzi CL-B5 was used to search for anti-epimastigote activity. Antileishmanial activity was determined using promastigotes of Leishmania braziliensis (MHOM/CW/88/UA301). NCTC 929 fibroblasts were used for the cytotoxicity test. The results showed that the main constituent of the essential oil was γ-elemene. No relevant effect was observed concerning the ability to reduce the DPPH radical; only at the concentration of 480 μg/mL did the essential oil demonstrate a high reduction of Fe3+ power. The oil was active against L. brasiliensis promastigotes; but not against the epimastigote form of T. cruzi. Cytotoxicity for mammalian cells was low at the active concentration capable of killing more than 70% of promastigote forms. The results revealed that the essential oil of R. echinus showed activity against L. brasiliensis; positioning itself as a promising agent for antileishmanial therapies.

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Cytotoxic and anti-kinetoplastid potential of the essential oil of Alpinia speciosa K. Schum

Cited by 21 publications

References 45 publications

Chemical Composition, Antimicrobial and Antiparasitic Screening of the Essential Oil from Phania matricarioides (Spreng.) Griseb.

Chemical Composition, Antimicrobial and Antiparasitic Screening of the Essential Oil from Phania matricarioides (Spreng.) Griseb.

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

A Potential New Source of Therapeutic Agents for the Treatment of Mucocutaneous Leishmaniasis: The Essential Oil of Rhaphiodon echinus

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