Cytotoxic and anti-inflammatory cembranoids from the Vietnamese soft coral Lobophytum laevigatum

A new steroid from the Red Sea soft coralLobophytum lobophytum

“…Some of these metabolites have been shown to exhibit significant cytotoxic activity against the growth of various cancer cell lines (Cheng et al 2008Hegazy et al 2011;Quang et al 2011) as well as anti-inflammatory (Chao et al 2008;Lin et al 2009;Lin et al 2009;Lu et al 2010;Quang et al 2011) and/or antioxidant activity report on chemical constituents of the species Lobophytum lobophytum which has not been previously chemically characterised.…”

Anti-Inflammatory Cembranoids from the Soft Coral Lobophytum crassum

“…Further investigation of this genus revealed more than 250 compounds categorized into cembrane-type diterpenoids [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58], other types of diterpenoids [59,60,61,62,63,64,65], lipids […”

Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.

“…Soft corals belonging to the genus Lobophytum (Alcyoniidae) have been shown to be a rich source of macrocyclic cembranoids and their cyclized derivatives [1,2,3,4,5,6,7,8,9,10,11,12,13,14], commonly described as defensive substances against predators such as other corals and fishes [15,16]. Some of these metabolites are of considerable interest and merit continuous attention due to their unique structures and significant biological activities, including anti-tumor, anti-viral, and anti-inflammatory properties [1,2,3,4,5,6,7,8,9,10,11,12,13,14].…”

“…Some of these metabolites are of considerable interest and merit continuous attention due to their unique structures and significant biological activities, including anti-tumor, anti-viral, and anti-inflammatory properties [1,2,3,4,5,6,7,8,9,10,11,12,13,14]. As part of our ongoing research on bioactive marine natural products from Lobophytum corals of South China Sea [17,18,19,20], a Hainan soft coral, Lobophytum sp., has been chemically investigated based on the EtOAc extracts showing cytotoxicity against a panel of tumor cell lines including SGC7901 (human gastric carcinoma), A549 (human lung epithelial carcinoma), MCF7 (human breast carcinoma), HCT116 (human colonic carcinoma), and B16 (mouse melanoma).…”