Cytotoxic activity of magnet-quided doxorubicin-based nanocomposites with Saccharomyces cerevisiae cells as an example

Turanska, S. P.; Kusyak, А. P.; Petranovska, А. L.; Gorobez’, S.V.; Туров, В. В.; Gorbyk, P. P.

doi:10.15407/hftp07.02.236

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…The using of drugs immobilized on the surface of Fe3O4 nanoparticles (MNPs) in the chemotherapeutic practice involves the preliminary modification of the surface of MNPs. (Akbarzadeh et al 2012;Liang et al 2016;Yang et al 2016;Abramov et al 2016Abramov et al , 2017Turanska et al 2016;Unsoy et al 2014;Sadighiana et al 2014;Kanamala et al2016;Shen et al 2018;Chen et al 2014). Due to the modification of MNPs new centers are formed to provide specific interaction with the target cell receptors [Price et al 2018;Yew et al 2018] and the absence of aggregate on is fixed (Chae et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Study of the adsorption activity of Fe3O4 synthesized by the solvothermal method in relation to doxorubicin

Kusyak

Storozhuk

et al. 2020

Appl Nanosci

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The solvothermal method synthesized magnetite (Fe3O4) and investigated the processes of immobilization of the cytostatic drug doxorubicin (DOX) on its surface in the medium of 0.9% NaCl solution. The size and morphology (transmission electron microscopy (TEM), crystalline phase magnetite formation (X-ray diffraction analysis (XRD), FTIR spectroscopy) and magnetic properties (vibration magnetometer (VSM), specific surface area and pore size were determined by the method of nitrogen thermal desorption were investigated for the synthesized samples. The adsorption processes were studied and the high adsorption activity of the Fe3O4 nanoparticles (MNPs) surface with respect to DOX was established in the model physiological environment. According to the studies, the adsorption equilibrium time is 45-90 min with up to 80% DOX extraction and maximum adsorption capacity (Amax) 17.5 mg•g -1 . The analysis of kinetic dependences and DOX adsorption isotherms using mathematical models that take into account the chemical interaction in the system indicates the monomolecular nature of adsorption (Freundlich model).Obtained MNPs can be potentially suitable for oncology applications specifically in the targeted drug delivery and adsorption materials of intracorporeal and extracorporeal detoxification of the body.

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Section: Introductionmentioning

confidence: 99%

Study of the adsorption activity of Fe3O4 synthesized by the solvothermal method in relation to doxorubicin

Kusyak

Storozhuk

et al. 2020

Appl Nanosci

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Biomedical nanocomposites with nanorobot functions: state of research, development, and prospects of practical introduction

Gorbyk¹

2020

Him. Fiz. Tehnol. Poverhni

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Synthesis and properties of magnetosensitive polyfunctional nanocomposites for application in oncology

Абрамов¹,

Kusyak²,

Kaminskiy³

et al. 2017

Poverhn.

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Наведено результати досліджень, спрямованих на розвиток концепції створення магніточутливих нанокомпозитів (НК) з багаторівневою ієрархічною наноархітектурою та функціями медико-біологічних нанороботів. Синтезовані нанорозмірний магнетит в однодоменному стані і магніточутливі НК на його основі (Fe 3 O 4 /дімеркаптосукцинова кислота (ДМСК), Fe 3 O 4 /γ-амінопропілсилоксан

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Cytotoxic activity of magnet-quided doxorubicin-based nanocomposites with Saccharomyces cerevisiae cells as an example

Cited by 4 publications

References 13 publications

Study of the adsorption activity of Fe3O4 synthesized by the solvothermal method in relation to doxorubicin

Study of the adsorption activity of Fe3O4 synthesized by the solvothermal method in relation to doxorubicin

Biomedical nanocomposites with nanorobot functions: state of research, development, and prospects of practical introduction

Synthesis and properties of magnetosensitive polyfunctional nanocomposites for application in oncology

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