Cytotoxic Activity of a Cold Atmospheric Plasma Jet in Relation to a 3D Cell Model of Human Breast Cancer

Patrakova, Ekaterina; Biryukov, Mikhail; Troitskaya, Olga; Novak, Diana; Milakhina, E. V.; Гугин, П. П.; Zakrevsky, D. É.; Schweigert, I. V.; Koval, Olga

doi:10.1134/s1990519x23030094

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…In recent studies, indirect treatment using plasma treated liquids (PTLs) [49,50] or plasma treated hydrogels (PTHs) [51] has shown enhanced cytotoxicity and anticancer immune responses, attributed to the long-lived reactive oxygen and nitrogen species (RONS) such as H2O2, NO2 − , NO3 − [52]. These treatments have demonstrated greater effectiveness than direct plasma treatment [53][54][55][56][57]. However, despite their advantages, concerns regarding the lack of consistent molecular-level analysis and precise control over their chemical compositions have been raised, limiting their clinical suitability.…”

Section: Mathematical Models For Cap Treatment Response In Cancermentioning

confidence: 99%

Personalized Plasma Medicine for Cancer: Transforming Treatment Strategies with Mathematical Modeling and AI Algorithms

Devi,

Keidar

2023

Preprint

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Plasma technology shows tremendous potential for revolutionizing oncology research and treatment. Reactive oxygen and nitrogen species, electromagnetic emissions generated through gas plasma jets, have attracted significant attention due to their selective cytotoxicity towards cancer cells. To leverage the full potential of plasma medicine, researchers have explored the use of mathematical models and various subsets of machine learning, such as reinforcement learning, and deep learning. This review emphasizes the significant application of AI algorithms in the adaptive plasma system, paving the way for precision and dynamic cancer treatment. Realizing the full potential of AI in plasma medicine, requires research efforts, data sharing and interdisciplinary collaborations. Unravelling the complex mechanisms, developing real-time diagnostics, and optimizing AI models will be crucial to harness the true power of plasma technology in oncology. The integration of personalized and dynamic plasma therapies, alongside AI and diagnostic sensors, presents a transformative approach to cancer treatment with the potential to improve outcomes globally.

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Section: Mathematical Models For Cap Treatment Response In Cancermentioning

confidence: 99%

Personalized Plasma Medicine for Cancer: Transforming Treatment Strategies with Mathematical Modeling and AI Algorithms

Devi,

Keidar

2023

Preprint

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“…The search for new antitumor approaches is not limited to the development of new drugs, but also stimulates the application of advanced physical modalities. Cold atmospheric plasma (CAP) has been applied to kill various tumor cells [1][2][3][4][5][6][7][8][9] and spheroids [10,11] in vitro. It is a new and rapidly developed method of therapy for malignant neoplasms [12,13].…”

Section: Introductionmentioning

confidence: 99%

The Molecular Basis for Selectivity of the Cytotoxic Response of Lung Adenocarcinoma Cells to Cold Atmospheric Plasma

Biryukov,

Semenov,

Kryachkova

et al. 2023

Biomolecules

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The interaction of cold atmospheric plasma (CAP) with biotargets is accompanied by chemical reactions on their surfaces and insides, and it has great potential as an anticancer approach. This study discovers the molecular mechanisms that may explain the selective death of tumor cells under CAP exposure. To reach this goal, the transcriptional response to CAP treatment was analyzed in A549 lung adenocarcinoma cells and in lung-fibroblast Wi-38 cells. We found that the CAP treatment induced the common trend of response from A549 and Wi-38 cells—the p53 pathway, KRAS signaling, UV response, TNF-alpha signaling, and apoptosis-related processes were up-regulated in both cell lines. However, the amplitude of the response to CAP was more variable in the A549 cells. The CAP-dependent death of A549 cells was accompanied by DNA damage, cell-cycle arrest in G2/M, and the dysfunctional response of glutathione peroxidase 4 (GPx4). The activation of the genes of endoplasmic reticulum stress and ER lumens was detected only in the A549 cells. Transmission-electron microscopy confirmed the alteration of the morphology of the ER lumens in the A549 cells after the CAP exposure. It can be concluded that the responses to nuclear stress and ER stress constitute the main differences in the sensitivity of tumor and healthy cells to CAP exposure.

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Cold atmospheric plasma-activated medium for potential ovarian cancer therapy

Tabassum,

Khan,

Faiz

et al. 2024

Mol Biol Rep

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Cytotoxic Activity of a Cold Atmospheric Plasma Jet in Relation to a 3D Cell Model of Human Breast Cancer

Cited by 5 publications

References 34 publications

Personalized Plasma Medicine for Cancer: Transforming Treatment Strategies with Mathematical Modeling and AI Algorithms

Personalized Plasma Medicine for Cancer: Transforming Treatment Strategies with Mathematical Modeling and AI Algorithms

The Molecular Basis for Selectivity of the Cytotoxic Response of Lung Adenocarcinoma Cells to Cold Atmospheric Plasma

Cold atmospheric plasma-activated medium for potential ovarian cancer therapy

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