Cytotoxic Activity of a Black Bean (&lt;I&gt;Phaseolus vulgaris&lt;/I&gt; L.) Extract and its Flavonoid Fraction in Both in vitro and in vivo Models of Lymphoma

Aregueta‐Robles, Ulises A.; Fajardo-Ramírez, Óscar R; Villela, Luís; Gutiérrez-Uribe, Janet A.; Hernández-Hernández, José Ascención; López-Sánchez, R.; Scott, Sean-Patrick; Saldivar, S.O. Serna

doi:10.24875/ric.17002395

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…Likewise, flavonoids from black soybean hulls can inhibit the proliferation of lymphoma cells. In addition, after exposure to this compound, the cells underwent apoptosis and the cell population in phase‐S increased (Aregueta‐Robles et al., 2018). In recent years, there have been many studies regarding anthocyanins and flavonoids in black soybean hulls, while the role of soluble dietary fibers (SDFs) from black soybean hulls was rarely reported.…”

Section: Introductionmentioning

confidence: 99%

Soluble dietary fibers from black soybean hulls: Physical and enzymatic modification, structure, physical properties, and cholesterol binding capacity

Shen

Wang

Cao

2020

Journal of Food Science

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We used ultrasound‐microwave comodification and enzyme modification (cellulase and hemicellulase) methods to extract soluble dietary fibers (SDFs) from black soybean hulls. Moreover, the structure, physical, and chemical properties, as well as the cholesterol‐binding capacity of SDFs before and after modification were analyzed. The average molecular weight of SDFs extracted from raw black soybean hulls was 2.815 × 105 Da. By comparison, the average molecular weight of SDFs from ultrasound‐microwave comodified hulls and enzyme‐modified hulls decreased by 33.21% and 45.29%, respectively. The water‐holding capacity (WHC), water‐swelling capacity (WSC), and oil‐holding capacity (OHC) of the extracted SDFs modified by the ultrasound‐microwave method were 3.79 g/g, 1.39 mL/g, and 1.14 g/g, respectively, a 9.54%, 23.01%, and 17.53% increase from the values of raw SDF. The WHC, WSC, and OHC of SDFs modified via the enzyme method were 3.59 g/g, 1.25 mL/g, and 1.03 g/g, respectively, with a 3.76%, 10.62%, and 6.19% increase when compared to raw SDFs. The cholesterol‐binding capacity of SDFs modified via the ultrasound‐microwave and enzyme methods was 13.82 and 12.34 mg/g, respectively, with an increase of 47.98% and 32.20% when compared to raw SDFs. The changes in structure and physical and chemical properties were shown to be closely related to the significantly improved cholesterol‐binding capacity of the SDFs from modified black soybean hulls. This provides a theoretical basis for subsequent research and development of black soybean hulls products. Practical Application At present, the black soybean hull, a byproduct of general grains, is usually abandoned, but black soybean hull is rich in dietary fiber. Enzymatic modification and ultrasound‐microwave comodification were used to treat black soybean hull to prepare small molecular weight, highly active soluble dietary fiber. This research is of great significance to the deep processing of black soybean hull and improvement of the economic benefits of black soybean byproducts.

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Section: Introductionmentioning

confidence: 99%

Soluble dietary fibers from black soybean hulls: Physical and enzymatic modification, structure, physical properties, and cholesterol binding capacity

Shen

Wang

Cao

2020

Journal of Food Science

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“…These evidences suggest that diet may be a risk factor or a preventive agent for lymphomas. Indeed several natural or synthetic products (Menezes et al, 2016;Aregueta-Robles et al, 2018;Ye et al, 2018) are reported to reduce the risk of certain types of lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effects of Fermented Brown Rice and Rice Bran on Spontaneous Lymphomagenesis in AKR/NSlc Female Mice

Kuno

Kato

Naiki‐Ito

et al. 2018

Asian Pac J Cancer Prev

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Fermented brown rice and rice bran with Aspergillus oryzae (FBRA) is known to possess potentials to prevent chemical carcinogenesis in multiple organs of rodents. In the present study, possible chemopreventive effect of FBRA against spontaneous occurrence of lymphomas was examined using female AKR/NSlc mice. Four-week-old female AKR/NSlc mice were divided into three groups, and fed diets containing FBRA for 26 weeks at a dose level 0% (Group 1), 5% (Group 2) or 10% (Group 3). At the termination of experiment, the incidence of thymic malignant lymphoma of Group 3 was significantly lower than of Group 1 (p < 0.05). The average number of apoptotic cells of the thymic lymphoma of Group 3 was significantly larger than that of Group 1 (p < 0.05). In addition, the incidences of malignant lymphoma arising from body surface and abdominal lymph nodes, and the frequencies of lymphoma cell invasion to liver, kidney, spleen, and ovary of Group 3 were relatively lower than those of Group 1. These results indicate that FBRA inhibits spontaneous development of the lymphoma in female AKR/NSc mice and the inhibition of lymphomagenesis may relate to the induction of apoptosis by exposure of FBRA, suggesting that FBRA could be a protective agent against development of human lymphoma.

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“…Many studies reported that phenolic and flavonoids that are derived from plants exhibit potent anti-inflammatory activity by regulating the concentration of various inflammatory cytokines or mediators such as cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF-α), and nuclear factor-kappa (NF-κB), interleukin 1, interleukin 6, interleukin 10, nitric oxide (NO), lipoxygenase (LOX), and iNOS [8]. Flavonoids isolated from black bean hulls can affect cell cycle by inducing cell cycle arrest at the S-phase and preventing progression to G2/M stages, as well as causing activation of apoptosis on OCI-Ly7 lymphoma cells in mouse [57]. In another experiment, phytosterol treatment reduces the development of production of carcinogens, inhibits cell growth, and also promotes apoptosis in cancer cells [10].…”

Section: Anticancer Activitiesmentioning

confidence: 99%

Nutraceutical Properties of Legume Seeds: Phytochemical Compounds

Thi¹,

Nguyen²

2022

Legumes Research - Volume 2

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Legume seeds have an important role as nutraceuticals in human health (providing protein, carbohydrates, fiber, amino acids, and micronutrients) and act as sustainable food sources in livestock farming and aquaculture. Legume seeds contain a wide range of bioactive compounds that have significant health benefits, mainly classified under phenolic compounds, phytosterols, oligosaccharides, carbohydrates, and saponins. Some of these compounds play an important role in plant defense mechanisms against predators and environmental conditions. Heat-labile antinutritional factors (protease inhibitors and lectins) and heat-stable antinutritional factors (tannins and phytic acid) can be reduced by thermal treatment or postharvest to eliminate any potential negative effects from consumption. Substantial studies have demonstrated that these bioactive compounds possess multiple biological activities, including antioxidant properties, antibacterial, anticancer, anti-inflammatory, antidiabetic, cardiovascular protective. They also have various values for aquaculture, such as fishmeal alternative. In this review, the main bioactive compounds and important biological functions of legume seeds are summarized, and the mechanism of action is discussed.

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Cytotoxic Activity of a Black Bean (<I>Phaseolus vulgaris</I> L.) Extract and its Flavonoid Fraction in Both in vitro and in vivo Models of Lymphoma

Abstract: BBE and FF had cytotoxic action by driving OCI-Ly7 cells into apoptosis as well as blocking progression to G2/M phase. In addition, BBE and FF treatments were effective in xenograft models.

Cited by 8 publications

References 24 publications

Soluble dietary fibers from black soybean hulls: Physical and enzymatic modification, structure, physical properties, and cholesterol binding capacity

Soluble dietary fibers from black soybean hulls: Physical and enzymatic modification, structure, physical properties, and cholesterol binding capacity

Preventive Effects of Fermented Brown Rice and Rice Bran on Spontaneous Lymphomagenesis in AKR/NSlc Female Mice

Nutraceutical Properties of Legume Seeds: Phytochemical Compounds

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