Cytotoxic Activities of Certain Medicinal Plants on Different Cancer Cell Lines

Uğur, Deniz; Güneş, Hatice; Güneş, Fatma; Mammadov, Ramazan

doi:10.4274/tjps.80299

Cited by 21 publications

(8 citation statements)

References 15 publications

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“…By day 3, many infected cells developed balloon-like, cytoplasmic swelling. These observations agreed with previous reports of many scholars who used the MT-4 cell line to evaluate the anti-HIV activity of various compounds [ 2 , 36 , 42 , 43 , 44 ].…”

Section: Methodssupporting

confidence: 92%

“…The effective inhibitory concentration at 50% (IC 50 ) is defined as the concentration of the test compound that achieves 50% protection in infected cultures. The efficacy of the test compounds, was determined by calculating the viral inhibition rate (Emax AV ) using Equation (1), as previously described by [ 43 , 47 ].

where,

is the optical density measured at a given concentration of the test compound in HIV-infected cells;

is the optical density measured for the negative control infected untreated cells;

is the optical density measured for the negative control uninfected untreated cells.…”

Section: Methodsmentioning

confidence: 99%

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Anti-HIV Ermiasolides from Croton megalocarpus

et al. 2022

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In recent years, elucidation of novel anti-HIV bioactive compounds from natural products is gaining importance rapidly, not only from the research and publications, but also from controlled clinical studies. Here we report three new anti-HIV eudesmane-type sesquiterpenes, 5β-Hydroxy-8α-methoxy eudesm-7(11)-en-12,8-olide (1), 5β,8α-Dihydroxy eudesm-7(11)-en-12,8-olide (2) and 5β-Hydroxy-8H-β-eudesm-7(11)-en-12,8-olide (3). These are trivially named ermiasolide A-C and were isolated from the bark of Croton megalocarpus. 5β-Hydroxy-8α-methoxy eudesm-7(11)-en-12,8-olide (1), showed the highest anti-HIV activity by inhibiting 93% of the viral replication with an IC50 = 0.002 µg/mL. On the other hand, 5β-Hydroxy-8H-β-eudesm-7(11)-en-12,8-olide (3) and 5β,8α-dihydroxy eudesm-7(11)-en-12,8-olide (2), inhibited viral replication by 77.5% at IC50 = 0.04 µg/mL and 69.5% at IC50 = 0.002 µg/mL, respectively. Molecular docking studies showed that the proposed mechanism of action leading to these results is through the inhibition of HIV-protease.

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Section: Methodssupporting

confidence: 92%

where,

is the optical density measured at a given concentration of the test compound in HIV-infected cells;

is the optical density measured for the negative control infected untreated cells;

is the optical density measured for the negative control uninfected untreated cells.…”

Section: Methodsmentioning

confidence: 99%

Anti-HIV Ermiasolides from Croton megalocarpus

et al. 2022

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“…Natural products are considered as a promising approach to cancer control and management [ 1 ]. Several studies investigated the cytotoxic potential of phytoconstituents against variable cancer cell lines [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity and Metabolic Profiling of Fifteen Euphorbia Species

et al. 2020

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Euphorbia is a large genus of flowering plants with a great diversity in metabolic pattern. Testing the cytotoxic potential of fifteen Euphorbia species revealed highest activity of E. officinarum L. against human colon adenocarcinoma (CACO2) cell line (IC50 7.2 µM) and of E. lactea Haw. against human hepatoma (HepG2) and human breast adenocarcinoma (MCF-7) cell lines (IC50 5.2 and 5.1 µM, respectively). Additionally, metabolic profiling of the fifteen tested species, using LC-HRMS, for dereplication purposes, led to the annotation of 44 natural compounds. Among the annotated compounds, diterpenoids represent the major class. Dereplication approach and multivariate data analysis are adopted in order to annotate the compounds responsible for the detected cytotoxic activity. Results of Principle component analysis (PCA) come in a great accordance with results of biological testing, which emphasized the cytotoxic properties of E. lactea Haw. A similarity correlation network showed that the two compounds with the molecular formula C16H18O8 and C20H30O10, are responsible for cytotoxic activity against MCF-7 and HepG2 cell lines. Similarly, the compound with molecular formula C18H35NO correlates with cytotoxic activity against CACO2.

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“…In this regard, plant-derived compounds are a promising source of chemotherapeutic drugs. In the market today, many of the currently used chemotherapeutic medicines such as taxanes (docetaxel and paclitaxel), vinca alkaloids (vincristine, vinblastine, and semisynthetic drugs vindesine and vinorelbine), camptothecin derivatives (camptothecin and irinotecan), and epipodophyllotoxins (teniposide and etoposide) were initially isolated from medicinal plants [ 92 ].…”

Section: In Vitro Pharmacological Propertiesmentioning

confidence: 99%

Unraveling the Phytochemistry, Traditional Uses, and Biological and Pharmacological Activities of Thymus algeriensis Boiss. & Reut

Mahdi

Bakrim

Bitchagno

et al. 2022

Oxidative Medicine and Cellular Longevity

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Growing concern for public health has increased the need to change the paradigm towards a healthcare system that advocates holistic practices while reducing adverse effects. Herbal therapy is becoming an integral part of the therapeutic arsenal, and several successful plant-derived compounds/molecules are being introduced into the market. The medicinal plants belonging to the genus Thymus are among the most important species within the Lamiaceae family. One of them is Thymus algeriensis which is mainly distributed in the Mediterranean region. For a long time, this species has been used in traditional medicine to treat several disorders and diseases including inflammation, diabetes, rheumatism, digestive, and respiratory affections. This review describes the traditional uses, phytochemical composition, and biological and pharmacological activities of T. algeriensis extracts. Data were obtained using electronic databases such as SciFindern, ScienceDirect, Scopus, and Web of Science. Several plant-based extracts and a broad spectrum of identified secondary metabolites were highlighted and discussed with respective activities and modes of action. T. algeriensis represents a promising natural resource for the pharmaceutical industry mainly for antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. Considering these findings, more research is needed to transmute the conventional uses of T. algeriensis into scientifically sound information. Moreover, extensive preclinical, clinical, toxicological, and pharmacokinetic trials on this species and its derivatives compounds are required to underpin the mechanisms of action and ensure its biosafety and efficiency. This comprehensive review provides a scientific basis for future investigations on the use of T. algeriensis and derived compounds in health maintenance and promotion and disease prevention.

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Cytotoxic Activities of Certain Medicinal Plants on Different Cancer Cell Lines

Cited by 21 publications

References 15 publications

Anti-HIV Ermiasolides from Croton megalocarpus

Anti-HIV Ermiasolides from Croton megalocarpus

Cytotoxic Activity and Metabolic Profiling of Fifteen Euphorbia Species

Unraveling the Phytochemistry, Traditional Uses, and Biological and Pharmacological Activities of Thymus algeriensis Boiss. & Reut

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