Cytostatic pharmaceuticals as water contaminants

Jureczko, Marcelina; Kalka, Joanna

doi:10.1016/j.ejphar.2019.172816

Cited by 88 publications

(62 citation statements)

References 56 publications

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“…[ 41 ] It has been demonstrated that many cytotoxic drugs are present in hospital effluents as well as in aquifer. [ 42 ] Furthermore, TAM can lead to corneal toxicity, [ 43 ] and hence its accurate and fast detection is of high importance in terms of diagnosis.…”

Section: Sensing Capabilitiesmentioning

confidence: 99%

Universal Fabrication of Highly Efficient Plasmonic Thin‐Films for Label‐Free SERS Detection

Gullace

Montes‐García

Martín

et al. 2021

Small

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The development of novel, highly efficient, reliable, and robust surface enhanced Raman scattering (SERS) substrates containing a large number of hot spots with programmed size, geometry, and density is extremely interesting since it allows the sensing of numerous (bio‐)chemical species. Herein, an extremely reliable, easy to fabricate, and label‐free SERS sensing platform based on metal nanoparticles (NPs) thin‐film is developed by the layer‐by‐layer growth mediated by polyelectrolytes. A systematic study of the effect of NP composition and size, as well as the number of deposition steps on the substrate's performance, is accomplished by monitoring the SERS enhancement of 1‐naphtalenethiol (532 nm excitation). Distinct evidence of the key role played by the interlayer (poly(diallyldimethylammonium chloride) (PDDA) or PDDA‐functionalized graphene oxide (GO@PDDA)) on the overall SERS efficiency of the plasmonic platforms is provided, revealing in the latter the formation of more uniform hot spots by regulating the interparticle distances to 5 ± 1 nm. The SERS platform efficiency is demonstrated via its high analytical enhancement factor (≈106) and the detection of a prototypical substance(tamoxifen), both in Milli‐Q water and in a real matrix, viz. tap water, opening perspectives towards the use of plasmonic platforms for future high‐performance sensing applications.

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Section: Sensing Capabilitiesmentioning

confidence: 99%

Universal Fabrication of Highly Efficient Plasmonic Thin‐Films for Label‐Free SERS Detection

Gullace

Montes‐García

Martín

et al. 2021

Small

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“…Pharmaceutical residues enter DT contents primarily via urine and feces, with different chemicals excreted via each waste stream. They may also be present in blood and vomit [86][87][88], but their share to DT content is marginal compared to human excreta. For this reason, we will only look into the relevance of residues in urine and feces.…”

Section: Pollution Characteristics Of Human Excretamentioning

confidence: 99%

Qualitative Risk Analysis for Contents of Dry Toilets Used to Produce Novel Recycling Fertilizers

Krause

Häfner

Augustin³

et al. 2021

Circ.Econ.Sust.

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Human excreta are a sustainable, economical source of nutrients, and can be used to produce recycling fertilizer for horticulture by collecting and processing the contents of dry toilets. Herein, we discuss the key categories of risk associated with the main groups of materials commonly found in dry toilets. The study was part of the development of a German product standard for marketable and quality-assured recycling fertilizers from human excreta for use in horticulture. Particular attention is paid to ensuring that the fertilizer is epidemiologically and environmentally harmless and that the quality of the recycling fertilizer is adequate in terms of low pollution and nutrient availability. In sum, the risk of transmissible human pathogens lies within the human excreta, particularly feces; plant materials added during composting are of particular phytosanitary relevance; pharmaceutical residues in excrements and chemical additives are potential sources of pollutants; non-biodegradable contaminants can cause pollution and injury; and the horticultural risks involve mainly the ammonia emission potential and in some cases the salinity effects of urine. These risks can be reduced significantly (i) with education of users around proper operation of dry toilets and the consequences of adding inappropriate waste, (ii) with facilitation of proper use with general waste bins and clear instructions, and importantly (iii) by using modern sanitization and cleaning processes and testing for harmful substances under the guidance of local laws and regulations, ensuring safe and high-quality fertilizers. In conclusion, the benefits of using dry toilet contents to produce fertilizers for use in horticulture are unquestionable. Our analysis highlights the need to support recycling optimization and awareness for the purpose of a sustainable circular economy and to minimize the risk of harm to humans and the environment overall.

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“…The pollutants contained in wastewater (WW) are a group of heterogeneous substances [8]. Besides pathogens, bacteria and genes resistant to antibiotics [9], the main pollutants include organic compounds such as pharmaceuticals, personal care products, perfluorinated compounds, pesticides, surfactants, flame retardants, dyes and a wide variety of industrial additives and synthetic chemical compounds [5,[10][11][12][13][14]. Among these pollutants, the group of emerging contaminants (ECs) stands out due to their bioaccumulable, persistent and toxic character, along with their carcinogenic and mutagenic potential, posing a risk to human health and the environment [15][16][17][18], and constituting a concern of great interest nowadays [19].…”

Section: Introductionmentioning

confidence: 99%

Advanced Oxidation Processes Based on Sulfate Radicals for Wastewater Treatment: Research Trends

Urán-Duque

Saldarriaga-Molina

Rubio-Clemente

2021

Water

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In this work, the recent trends in the application of the sulfate radical-based advanced oxidation processes (SR-AOPs) for the treatment of wastewater polluted with emerging contaminants (ECs) and pathogenic load were systematically studied due to the high oxidizing power ascribed to these technologies. Additionally, because of the economic benefits and the synergies presented in terms of efficiency in ECs degradation and pathogen inactivation, the combination of the referred to AOPs and conventional treatments, including biological processes, was covered. Finally, the barriers and limitations related to the implementation of SR-AOPs were described, highlighting the still scarce full-scale implementation and the high operating-costs associated, especially when solar energy cannot be used in the oxidation systems.

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Cytostatic pharmaceuticals as water contaminants

Cited by 88 publications

References 56 publications

Universal Fabrication of Highly Efficient Plasmonic Thin‐Films for Label‐Free SERS Detection

Universal Fabrication of Highly Efficient Plasmonic Thin‐Films for Label‐Free SERS Detection

Qualitative Risk Analysis for Contents of Dry Toilets Used to Produce Novel Recycling Fertilizers

Advanced Oxidation Processes Based on Sulfate Radicals for Wastewater Treatment: Research Trends

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