Cytostatic activity of coumarin metabolites and derivatives in the B16-F10 murine melanoma cell line

In vitrophoto-induced cytotoxic activity ofCitrus bergamiaandC. medicaL. cv. Diamante peel essential oils and identified active coumarins

“…Coumarins comprise a very large class of compounds found throughout the plant kingdom (Egan et al, 1990). The biological activity of coumarins and more complex related derivatives appears to be based on the coumarin nucleus and several study reported the cytostatic activity of these natural products against neoplastic skin cell line (Jimenez-Orozco et al, 1999;Finn et al, 2001). On the basis of these studies we included in our work the furanocoumarin bergapten and the coumarin citropten derived from Citrus species.…”

The effects of oridonin on cell growth, cell cycle, cell migration and differentiation in melanoma cells

“…The effect of oridonin on the growth of melanoma cells was determined using a modification of procedure described previously (Jimenez-Orozco et al, 1999). Murine K1735M2 cells were maintained as monolayer cultures in MEM with 5% FBS and antibiotics (100 units of penicillin/ml and 100 g streptomycin/ml).…”

Calorimetric and computational study of 7-hydroxycoumarin

“…It was also found that the 6-hydroxycoumarin has cytostatic effects on melanoma cells [8]. Umbeliferone, 7-hydroxycoumarin, is very common in plants of the Umbeliferae family as carrots and corianders.…”