Cytosolie and Nuclear Sex Steroid Receptors In Meningioma

Moguilewsky, M.; Bf, Pertuiset; Verzat, C.; Philibert, D.; Philippon, J; Poisson, M

doi:10.1097/00002826-198412000-00018

Cited by 17 publications

(9 citation statements)

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“…Although AR and PR were positively correlated in these tumors, they were independent of the presence of ER. The same situation has been described in meningiomas (Moguilewsky et al, 1984). However, these findings should not be construed as evidences to rule out a possible action mediated by the presence of ER within the nuclei of those benign tumors.…”

Section: Discussionsupporting

confidence: 67%

Androgen, estrogen, and progesterone receptor levels in malignant and benign breast tumors: A multivariate analysis approach

Brentani

Franco

Oshima³

et al. 1986

Intl Journal of Cancer

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Androgens have been frequently used in the treatment of breast cancer. However, objective responses seem to vary according to the steroid hormone receptor expression of the tumor. We have studied the relationship between concentrations of androgen receptors (AR) and those of estrogen (ER) and progesterone (PR) receptors by multiple regression and stratified analysis techniques in 154 cases of primary breast carcinomas and 39 cases of benign tumors. Both the proportion of AR-positive tumors and the concentration of AR were dependent upon the coexpression of ER and PR by the specimens. This association was evident for malignant tumors with predominance of the positive correlation between AR and ER over that of AR and PR in post-menopausal patients. In premenopausal women, ER and PR concentrations were similarly correlated with AR levels. The PR, but not the ER concentration, was positively correlated to AR levels in benign breast tumors. These findings were confirmed by multiple regression, taking into consideration additional information about the patients to build statistical models allowing prediction of AR. Among the other variables considered in building these models--age, menopausal status, weight, height, and clinical stage--only height (using data from all patients) and age (data from post-menopausal women) emerged in addition to ER and PR as significantly explaining the variability of AR as the dependent variable.

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Section: Discussionsupporting

confidence: 67%

Androgen, estrogen, and progesterone receptor levels in malignant and benign breast tumors: A multivariate analysis approach

Brentani

Franco

Oshima³

et al. 1986

Intl Journal of Cancer

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“…Progesterone binds to meningiomas in 50-100% of specimens tested, with most authors reporting binding at the higher end of this range [13][14][15][16][20][21][22]. It attaches to a high-affinity site, indicating a true receptor.…”

Section: Progesterone Studiesmentioning

confidence: 99%

“…No relation has been found between progesterone receptor status and age, sex, location of tumor, or menopausal state [14]. In addition, attempts to correlate different histologies to progesterone receptor status have shown that the more aggressive atypical and angioblastic tumor types, which would logically be more likely to have functional progesterone receptors if such receptors were important for cell growth, are instead less likely to have them [22][23][24]. Further complicating the matter are conflicting reports on the proportion of the progesterone receptor in the cytosol versus the nucleus [14,20,21,23,25].…”

Section: Progesterone Studiesmentioning

confidence: 99%

“…Because androgen receptors have been found in 40-100% of meningiomas studied by a variety of methods, they are also considered of possible relevance in these tumors [15,22,30]. By this estimate, they are almost as common as progesterone receptors, but studies in this area are just now beginning, and conclusive evidence is not yet available.…”

Section: Androgen Studiesmentioning

confidence: 99%

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The biology of meningiomas

McCutcheon

1996

J Neuro-Oncol

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Meningiomas, long neglected as a subject for biological studies, are now being examined more widely as their potential for clinical recurrence and malignancy has been recognized. Most laboratory studies have focused on descriptive analyses of the content of various molecules in ex vivo specimens removed at surgery. Perturbative experiments using cultured cells are possible, but they are complicated by senescence of the cells. The respective importance of the sex steroids (estrogen, progesterone, and androgens), classical growth factors, angiogenic factors, and proteolytic enzymes in the biological behavior of meningiomas is now apparent and is coming under more detailed scrutiny. As general theories of neoplasia crystallize in other systems, the ability of meningiomas to proliferate, invade, and provoke neovascularization will be better understood.

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“…But in contrast to other known antiglucocorticoids, like carboxamide derivatives of dexamethasone, RU 38486 forms stable complexes with the glucocorticoid receptor protein under low temperature conditions. These are destabilized only after heat activation, thus prohibiting an effective nuclear translocation (22).…”

Section: Time Studies Of [mentioning

confidence: 99%

3H-Labelled RU 38486: Characterization of Binding Sites in Human Uterine Cytosol

Heubner¹,

Pollow²,

Manz³

et al. 1985

Clinical Chemistry and Laboratory Medicine

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Summary:The behaviour of the antifertilizing synthetic steroid RU 38486 towards human uterine progestin receptor was investigated. RU 38486 competed in the same order of magnitude äs progesterone for the [ 3 H]R 5020 binding site of progestin receptor, whereas R 5020 was unable to compete against [ 3 H]RU 38486. This apparent contradiction could be explained by means of HPLC-chroniatography. HPLC-chromatography with an anion exchange column (MonoQ, Pharmacia, Uppsala, Sweden) showed that [ 3 H]RU 38486 forms at least two stable complexes with uterine cytosol, on one hand with serum albumin, which presents almost 90% of bound radioactivity, and on the other hand with the two native progestin receptor forms, corresponding to 4 S and 8 S receptor forms in sucrose density gradient analysis.Whether reduced binding of salt-activated RU 38486 receptor complexes to DNA-cellulose is due to reduced activation is still uncertain and remains to be further investigated. H-Markiertes RU38486: Charakterisierung der Bindungseigenschaften in Cytosol aus Introductionprogesterone in vivo, a property that is manifested "~~ ~^ , , ^ . ,~ intheinterruptionofthelutealphaseofthemenstrual RU 38486 (structure see scheine 1) is the first cycle of ^y pregnancy in women . synthetic steroid possessmg a greater afnnity for the progestin receptor in different animal target tissues There are some indications that the potent antagonist than progesterone, but without exhibiting any agonist effect of RÜ 38486 is related to the essential bioprogestin activity (1-3). Moreover, at large doses chemical Steps following progestin receptor this steroid is capable of antagonizing the effects of occupancy which leäd to the biological response i. e.

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Cytosolie and Nuclear Sex Steroid Receptors In Meningioma

Cited by 17 publications

References 0 publications

Androgen, estrogen, and progesterone receptor levels in malignant and benign breast tumors: A multivariate analysis approach

Androgen, estrogen, and progesterone receptor levels in malignant and benign breast tumors: A multivariate analysis approach

The biology of meningiomas

3H-Labelled RU 38486: Characterization of Binding Sites in Human Uterine Cytosol

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