Cytosolic Phospholipase A2 (PLA2G4A) Polymorphisms Associated with Acute Urticaria/angioedema Induced by Nonsteroidal Anti-inflammatory Drugs

Abstract

Piperacillin, is a b-lactam, usually used for treatment of severe hospital-acquired infections. METHODS: We retrospectively analysed 649 medical records with a suspicion of drug allergy, 24 patients of which were studied for piperacillin-tazobactam allergy. RESULTS: We included13 women and 11 men. Average age was 65,54 years (616,31, age range 29-90). 18 patients were included per protocol; 8 of them (44,4%) presented delayed reaction and 10 (55,6%) immediate reaction. Among immediate reactions; 4 patients presented anaphylaxis, 2 had hypotension and 2 itching and cutaneous symptoms. 80% developed symptoms with the first administration. Delayed reactions appeared 2 to 22 days after treatment was initiated, average 8,71 days(66,55). Most common symptom was maculopapular rash (90%), 2 added itching and 1 skin desquamation. Allergic study included skin prick, intradermal and patch test with the main components involved in b-lactam allergy, also piperacillin. Finally, 9 patients were diagnosed of piperacillin allergy, 6 of them