Cytosolic phospholipase A2 group IVA is overexpressed in patients with persistent asthma and regulated by the promoter microsatellites

Sokołowska, Milena; Stefańska, Joanna; Wódz-Naskiewicz, Karolina; Cieślak, M; Pawliczak, Rafał

doi:10.1016/j.jaci.2010.02.016

Cited by 28 publications

(27 citation statements)

References 14 publications

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“…Among them, products of all three pathways of AA metabolism, leukotrienes, prostanoids, as well as a number of cytochrome P450 metabolites, followed that trend (73). In our previous work, we have also described increased cPLA 2 ␣ expression in peripheral blood mononuclear cells in severe asthmatic patients (74). Likewise, cPLA 2 ␣ expression is markedly increased in polyps of Apc ⌬716 -knockout mice, a model of human familial adenomatous polyposis (70,75).…”

Section: Discussionmentioning

confidence: 74%

Low Molecular Weight Hyaluronan Activates Cytosolic Phospholipase A2α and Eicosanoid Production in Monocytes and Macrophages

Sokołowska

Chen

Eberlein

et al. 2014

Journal of Biological Chemistry

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Background: Fragmented hyaluronan (a major extracellular matrix component) and eicosanoids (potent lipid mediators) are associated with chronic inflammatory diseases and cancer. Results: Fragmented hyaluronan stimulates lipid mediator production in human monocytes and macrophages and influences macrophage differentiation toward a distinct activation pattern. Conclusion: These findings reveal a novel link between hyaluronan-mediated inflammation and lipid metabolism. Significance: This link may provide new targets for disease therapeutics.

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Section: Discussionmentioning

confidence: 74%

Low Molecular Weight Hyaluronan Activates Cytosolic Phospholipase A2α and Eicosanoid Production in Monocytes and Macrophages

Sokołowska

Chen

Eberlein

et al. 2014

Journal of Biological Chemistry

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“…Analysis of the promoter region of PLA2G4A has shown that microsatellite fragments are shorter in patients with severe asthma than healthy controls ( 197 ). A comparison of peripheral blood monocytes from severe asthmatics with short and long microsatellite sequences in the PLA2G4A promoter found a correlation between the shorter sequences with increased expression of cPLA 2 ␣ mRNA and protein, and greater eicosanoid production ( 197,198 ).…”

Section: Nervous Systemmentioning

confidence: 99%

Cytosolic phospholipase A2: physiological function and role in disease

Leslie

2015

Journal of Lipid Research

329

249

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“…This enzyme may have a role in asthma pathogenesis as group IVA cPLA 2 was over-expressed in patients with persistent asthma. 12 …”

Section: Generation Of Prostaglandins By Phospholipase A2mentioning

confidence: 99%

The role of prostaglandins in allergic lung inflammation and asthma

Claar

Hartert

Peebles³

2014

Expert Review of Respiratory Medicine

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Prostaglandins are products of the cyclooxygenase pathway of arachidonic acid metabolism. There are five primary prostaglandins, PGD2, PGE2, PGF2, PGI2, and thromboxane B2, all of which signal through distinct seven transmembrane, G-protein coupled receptors. Some prostaglandins may counteract the actions of others, or even the same prostaglandin may have opposing physiologic or immunologic effects, depending on the specific receptor through which it signals. In this review, we will examine the effects of cyclooxygenase activity and the various prostaglandins on allergic airway inflammation and physiology that is associated with asthma. We also highlight the potential therapeutic benefit of targeting prostaglandins in allergic lung inflammation and asthma based on basic science, animal model, and human studies.

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Cytosolic phospholipase A2 group IVA is overexpressed in patients with persistent asthma and regulated by the promoter microsatellites

Cited by 28 publications

References 14 publications

Low Molecular Weight Hyaluronan Activates Cytosolic Phospholipase A2α and Eicosanoid Production in Monocytes and Macrophages

Low Molecular Weight Hyaluronan Activates Cytosolic Phospholipase A2α and Eicosanoid Production in Monocytes and Macrophages

Cytosolic phospholipase A2: physiological function and role in disease

The role of prostaglandins in allergic lung inflammation and asthma

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