Abstract:Stefin B (cystatin B) is an endogenous cysteine cathepsin inhibitor, and the loss‐of‐function mutations in the stefin B gene were reported in patients with Unverricht‐Lundborg disease (EPM1). In this study we demonstrated that stefin B‐deficient (StB KO) mice were significantly more sensitive to the lethal LPS‐induced sepsis and secreted higher amounts of pro‐inflammatory cytokines IL‐1β and IL‐18 in the serum. We further showed that increased caspase‐11 gene expression and better pro‐inflammatory caspase‐1 an… Show more
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