Cytosol and serum ferritin in breast carcinoma

Güner, Gül; Kırkalı, Güldal; Yenisey, Çiğdem; Töre, I. Ruhi

doi:10.1016/0304-3835(92)90132-f

Cited by 49 publications

(27 citation statements)

References 26 publications

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“…These results indicate that ferritin concentrations may be a prognostic indicator in some patients with breast cancer. In this study the highest levels of ferritin were obtained in the group of patients with advanced disease, which was in agreement with previous reports (20,21).…”

Section: Discussionsupporting

confidence: 82%

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Serum Ferritin in Healthy Women and Breast Cancer Patients

Ćujić¹,

Stefanoska²,

Golubović³

2011

Journal of Medical Biochemistry

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Kratak sadr`aj: Serumski tumorski markeri su zna~ajno analiti~ko sredstvo u proceni kancera dojke. Trenutno najzna~ajniji markeri raka dojke, CA 15-3 antigen i CEA, su posebno zna~ajni u pra}enju pacijenata sa uznapredovalom bole{}u. Feritin pripada grupi drugih molekula koji mogu biti potencijalno interesantni u praksi i ~ija je koncentracija tako|e promenjena u serumu pacijenata sa tumorima dojke. U ovoj studiji serumska koncentracija feritina je odre|ena u grupi pacijenata sa kancerom dojke pre hirur{ke intervencije i grupi pacijenata sa uznapredovalom bole{}u i upore|ena je sa vrednostima izmerenim u populaciji zdravih `ena. Koncentracija feritina odre|ena je pomo}u imunoradio me trijskog testa. Cilj je bio da se utvrdi da li se serumska koncen tracija feritina menja u prisustvu kancera dojke i da li postoji veza sa napredovanjem bolesti. U populaciji zdravih `ena odre|ena je statisti~ki zna~ajna razlika (p<0,05) u koncentraciji serumskog feritina izme|u pre-i postme nopau zalnih `ena. Kod obe grupe pacijenata sa kancerom dojke serumski nivo feritina je bio vi{i u odnosu na nivo dobijen kod zdravih `ena pre menopauze (u oba slu~aja p<0,05). U pacijenata sa uznapre dovalom bole{}u, koncentracija serum skog feritina je bila vi{a (p<0,05) u odnosu na pre opera tivne vrednosti izmerene kod pacijenata koji su pod vrgnuti hirur{koj intervenciji. Ovi rezulatati ukazuju na to da bi merenje koncentracije feritina u serumu mla|ih `ena moglo da poslu`i kao dodatni parametar u dijagnozi i proceni sta dijuma kancera dojke.

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Section: Discussionsupporting

confidence: 82%

“…Iron overload may be present in neoplastic cells. There is a possibility that the determination of ferritin changes in the tissue would be a more effective parameter (20). Further analysis should be directed to identifying patients in whom tissue iron excess is present, and whether tissue ferritin levels correlate with serum concentration.…”

Section: Discussionmentioning

confidence: 99%

Serum Ferritin in Healthy Women and Breast Cancer Patients

Ćujić¹,

Stefanoska²,

Golubović³

2011

Journal of Medical Biochemistry

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“…174 However, subsequent evaluations of ferritin levels in tumor tissue itself have revealed a complex, perhaps disease-specific picture: for example, in some cases such as colon cancer, 175 testicular seminoma, 176 and breast cancer, 177,178 increases in ferritin in tumor tissue versus comparable normal tissue have been reported; in other cases, including liver cancer, a decrease in ferritin is seen. 179 New forms of ferritin may be involved in certain situations: Moroz and coworkers have described a novel isoform of ferritin that is elevated in the serum of patients with neoplastic breast disease as well as during pregnancy and HIV infection.…”

Section: Oncogenes Cancer and Ferritinmentioning

confidence: 99%

Regulation of ferritin genes and protein

Torti

2002

Blood

986

819

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“…Ferritin is a holoenzyme shell (ϳ450 kDa) consisting of 24 subunits of two types, H and L, and capable of storing up to 4,500 atoms of ferric iron. The H-to-L ratio within ferritin varies in a tissue-specific manner and is also influenced by pathophysiological conditions, including inflammation and malignancy (3,9,41,46). Ferritin H and L protein sequences are highly conserved among species, suggesting the importance of these proteins in regulating iron homeostasis (10,40).…”

mentioning

confidence: 99%

Coordinate Transcriptional and Translational Regulation of Ferritin in Response to Oxidative Stress

Tsuji

Ayaki

Whitman

et al. 2000

Molecular and Cellular Biology

257

213

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The global increase in transcription of cytoprotective genes induced in response to oxidative challenge has been termed the antioxidant response. Ferritin serves as the major iron-binding protein in nonhematopoietic tissues, limiting the catalytic availability of iron for participation in oxygen radical generation. Here we demonstrate that ferritin is a participant in the antioxidant response through a genetically defined electrophile response element (EpRE). The EpRE of ferritin H identified in this report exhibits sequence similarity to EpRE motifs found in antioxidant response genes such as those encoding NAD(P)H:quinone reductase, glutathione S-transferase, and heme oxygenase. However, the EpRE of ferritin H is unusual in structure, comprising two bidirectional motifs arranged in opposing directions on complementary DNA strands. In addition to EpREmediated transcriptional activation, we demonstrate that ferritin is subject to time-dependent translational control through regulation of iron-regulatory proteins (IRP). Although IRP-1 is initially activated to its RNA binding (ferritin-repressing) state by oxidants, it rapidly returns to its basal state. This permits the translation of newly synthesized ferritin transcripts and ultimately leads to increased levels of ferritin protein synthesis following oxidant exposure. Taken together, these results clarify the complex transcriptional and translational regulatory mechanisms that contribute to ferritin regulation in response to prooxidant stress and establish a role for ferritin in the antioxidant response.

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Cytosol and serum ferritin in breast carcinoma

Cited by 49 publications

References 26 publications

Serum Ferritin in Healthy Women and Breast Cancer Patients

Serum Ferritin in Healthy Women and Breast Cancer Patients

Regulation of ferritin genes and protein

Coordinate Transcriptional and Translational Regulation of Ferritin in Response to Oxidative Stress

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