Cytoskeleton, microtubules, tubulin and colchicine : A review.

Artvinli, Suad

doi:10.1508/cytologia.52.189

Cited by 12 publications

(3 citation statements)

References 151 publications

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“…Colchicine depolymerises already formed microtubules, thus affecting any cellular functions dependent on microtubules, including mitosis (Artvinli, 1987). That colchicine exposure at 3 DAI signi cantly reduced nematode development assessed at 21 and 30 DAI is in agreement with the report by Engler et al (1999) that a single exposure to a mitotic blocker at 3 DAI could prevent nematode maturation.…”

Section: Discussionsupporting

confidence: 90%

The effects of colchicine on number of giant cell nuclei and nematode development in Pisum sativum infected by Meloidogyne incognita

Wiggers¹,

Thornton²,

Starr³

2002

Nematol

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Section: Discussionsupporting

confidence: 90%

The effects of colchicine on number of giant cell nuclei and nematode development in Pisum sativum infected by Meloidogyne incognita

Wiggers¹,

Thornton²,

Starr³

2002

Nematol

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“…On the other hand, the morphological changes in the shoot tips and the delay in the emergence of suckers observed in plants treated with higher colchicine concentrations and longer exposure times, can be explained by functional disturbances which occurred simultaneously with the depolymerization of cytoplasmic labile microtubules, temporarily affecting the mobility or topography of membrane components and cell functions dependent on microtubules assembly and cytoskeleton (Artvinli 1987). …”

Section: Discussionmentioning

confidence: 99%

Colchicine-Induced Autotetraploid in Aloe vera L.

Buiza

Cequea

2001

CYTOLOGIA

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Summary Autotetraploid plants of Aloe vera L. were induced by colchicine treatment. Diploid shoot tips (2n =2x=14) were treated by immersion of the rhizomes in colchicine concentrations of 0.05%, 0.10% and 0.15% at exposure times of 6, 12, 18 and 24 h. The highest proportion of polyploid plants (5.9%) with 2n=4x=28 was obtained from a 0.15% colchicine and 24 h combination. Diploid/tetraploid chimerical plants were observed at the lowest colchicine concentration/time treatments. Expression of gigantism in morphological and cytological characters, such as, width and thickness of the leaves, size and frequency of juvenile foliar spots, plant weight, size of epidermal and root cells, were noted in autotetraploid plants with a significant decrease in stomatal frequency.

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“…In this respect, the cytoskeleton and its regulatory proteins play important roles in cell proliferation, cell shape and motility (Artvinli, 1987;Vogl et al, 1993;Vogl et al, 2008). For instance, cell migration is dependent on the actin network and its dynamics, which are regulated by a number of proteins such as cofilin (Pollard and Borisy, 2003;Dos Remedios et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Sub-lethal concentrations of CdCl2 disrupt cell migration and cytoskeletal proteins in cultured mouse TM4 Sertoli cells

Egbowon

Harris

Arnott

et al. 2016

Toxicology in Vitro

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The aims of this study were to examine the effects of CdCl2 on the viability, migration and cytoskeleton of cultured mouse TM4 Sertoli cells. Time-and concentration-dependent changes were exhibited by the cells but 1 µM CdCl2 was sub-cytotoxic at all time-points. Exposure to 1 and 12 µM CdCl2 for 4 h resulted in disruption of the leading edge, as determined by chemical staining. Cell migration was inhibited by both 1 and 12 µM CdCl2 in a scratch assay monitored by live cell imaging, although exposure to the higher concentration was associated with cell death. Western blotting and immunofluorescence staining indicated that CdCl2 caused a concentration dependent reduction in actin and tubulin levels. Exposure to Cd 2+ also resulted in significant changes in the levels and/or phosphorylation status of the microtubule and microfilament destabilising proteins cofilin and stathmin, suggesting disruption of cytoskeletal dynamics. Given that 1-12 µM Cd 2+ is attainable in vivo, our findings are consistent with the possibility that Cd 2+ induced impairment of testicular development and reproductive health may involve a combination of reduced Sertoli cell migration and impaired Sertoli cell viability depending on the timing, level and duration of exposure.

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Cytoskeleton, microtubules, tubulin and colchicine : A review.

Cited by 12 publications

References 151 publications

The effects of colchicine on number of giant cell nuclei and nematode development in Pisum sativum infected by Meloidogyne incognita

The effects of colchicine on number of giant cell nuclei and nematode development in Pisum sativum infected by Meloidogyne incognita

Colchicine-Induced Autotetraploid in Aloe vera L.

Sub-lethal concentrations of CdCl2 disrupt cell migration and cytoskeletal proteins in cultured mouse TM4 Sertoli cells

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