Cytoskeletal remodelling proteins identified in fetal-maternal interface in pregnant women and rhesus monkeys

Paule, Sarah; Liu, Ying; Nie, Guiying

doi:10.1007/s10735-011-9319-5

Cited by 11 publications

(13 citation statements)

References 23 publications

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“…116,117 It is noteworthy that LXA 4 and its analogs decrease MMP expression and activity in many different cell types 118,119 and also in peritoneal fluid cells in a mouse model of endometriosis, 120,121 of which macrophages comprise a major component.…”

Section: Macrophages As a Lxa4 Targetmentioning

confidence: 99%

The role of Lipoxin A4 in endometrial biology and endometriosis

Canny

Lessey

2013

Mucosal Immunology

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Lipoxin A4 (LXA4), an endogenous anti-inflammatory and immunomodulatory mediator studied in many disease states, is recently appreciated as a potentially significant player in the endometrium. This eicosanoid, synthesized from arachidonic acid via the action of lipoxygenase enzymes, is likely regulated in endometrial tissue during the menstrual cycle. Recent studies revealed that LXA4 acts as an estrogen receptor agonist in endometrial epithelial cells, antagonizing some estrogen-mediated activities in a manner similar to the weak estrogen estriol, with which it shares structural similarity. LXA4 may also be an anti-inflammatory molecule in the endometrium, though its precise function in various physiological and pathological scenarios remains to be determined. The expression patterns for LXA4 and its receptor in the female reproductive tract suggest a role in pregnancy. The present review provides an oversight of its known and putative roles in the context of immuno-endocrine crosstalk. Endometriosis, a common inflammatory condition and a major cause of infertility and pain, is currently treated by surgery or anti-hormone therapies that are contraceptive and associated with undesirable side effects. LXA4 may represent a potential therapeutic and further research to elucidate its function in endometrial tissue and the peritoneal cavity will undoubtedly provide valuable insights.

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Section: Macrophages As a Lxa4 Targetmentioning

confidence: 99%

The role of Lipoxin A4 in endometrial biology and endometriosis

Canny

Lessey

2013

Mucosal Immunology

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“…Previous studies identified a number of PC6‐regulated proteins in human endometrial decidual cells (7, 14, 15). However, as the luminal epithelium is the first contact between the endometrium and a blastocyst for implantation, identifying molecules that are directly regulated by PC6 for endometrial epithelial receptivity is critically important.…”

mentioning

confidence: 99%

Posttranslational removal of α-dystroglycan N terminus by PC5/6 cleavage is important for uterine preparation for embryo implantation in women

Heng¹,

Paule²,

Liu³

et al. 2015

The FASEB Journal

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Embryo implantation requires a healthy embryo and a receptive endometrium (inner lining of the uterus); endometrial receptivity acquisition involves considerable epithelial surface remodeling. Dystroglycan (DG), a large cell surface glycoprotein, consists of a-and b-subunits; b-DG anchors within the plasma membrane whereas a-DG attaches extracellularly to b-DG. The glycosylated central a-DG mediates adhesion, but it is obstructed by its large N terminus (a-DG-N); a-DG-N removal enables DG's adhesive function. We demonstrate here that full-length a-DG in the human endometrial epithelium is a barrier for embryo attachment and that removal of a-DG-N by proprotein convertase 5/6 (PC6; a protease critical for implantation) regulates receptivity. This was evidenced by: 1) a-DG contains a PC6-cleavage site near a-DG-N, and PC6 cleaves a peptide harboring such a site; 2) PC6 knockdown reduces a-DG-N removal from endometrial epithelial cell surface and blastocyst adhesion; 3) mutating the PC6-cleavage site prevents a-DG-N removal, causing cell surface retention of full-length a-DG and loss of adhesiveness; 4) a-DG-N is removed from endometrial tissue in vivo for receptivity and uterine fluid a-DG-N reflects tissue removal and receptivity. We thus identified a-DG-N removal as an important posttranslational control of endometrial receptivity and uterine fluid a-DG-N as a potential biomarker for receptivity in women.-Heng, S., Paule, S. G., Li, Y., Rombauts, L. J., Vollenhoven, B., Salamonsen, L. A., Nie, G. Posttranslational removal of a-dystroglycan N terminus by PC5/6 cleavage is important for uterine preparation for embryo implantation in women. FASEB J. 29, 4011-4022 (2015). www.fasebj.org

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“…This variant is associated with changes in expression of PPFIA1 and CTTN in adipose cells (ADP), mammary tissue (MRY), the thyroid (THY), and heart (HRT). CTTN is expressed the placenta 63 , 108 . d Group D (long-term polymorphism): rs10932774 is located in a PNKD intron and is in LD with 27 variants.…”

Section: Resultsmentioning

confidence: 99%

Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci

et al. 2020

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Currently, there is no comprehensive framework to evaluate the evolutionary forces acting on genomic regions associated with human complex traits and contextualize the relationship between evolution and molecular function. Here, we develop an approach to test for signatures of diverse evolutionary forces on trait-associated genomic regions. We apply our method to regions associated with spontaneous preterm birth (sPTB), a complex disorder of global health concern. We find that sPTB-associated regions harbor diverse evolutionary signatures including conservation, excess population differentiation, accelerated evolution, and balanced polymorphism. Furthermore, we integrate evolutionary context with molecular evidence to hypothesize how these regions contribute to sPTB risk. Finally, we observe enrichment in signatures of diverse evolutionary forces in sPTB-associated regions compared to genomic background. By quantifying multiple evolutionary forces acting on sPTB-associated regions, our approach improves understanding of both functional roles and the mosaic of evolutionary forces acting on loci. Our work provides a blueprint for investigating evolutionary pressures on complex traits.

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Cytoskeletal remodelling proteins identified in fetal-maternal interface in pregnant women and rhesus monkeys

Cited by 11 publications

References 23 publications

The role of Lipoxin A4 in endometrial biology and endometriosis

The role of Lipoxin A4 in endometrial biology and endometriosis

Posttranslational removal of α-dystroglycan N terminus by PC5/6 cleavage is important for uterine preparation for embryo implantation in women

Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci

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