Cytoskeletal Immunohistochemistry of Central Neurocytomas

Hessler, Richard B.; Lopes, M. Beatriz S.; Frankfurter, Anthony; Reidy, Jason; VandenBerg, Scott R.

doi:10.1097/00000478-199211000-00001

Cited by 85 publications

(40 citation statements)

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“…␤III is expressed, in conjunction with other neuronal cytoskeletal and synaptic proteins in central neuro-cytomas [Hessler et al, 1992], cerebral neuroblastomas [Katsetos et al, 2003], and olfactory neuroblastomas [Frierson et al, 1990;Hirose et al, 1995].…”

Section: Class III ␤-Tubulin In Other Neuronal Tumorsmentioning

confidence: 99%

Class III β‐tubulin in human development and cancer

Katsetos

Herman²,

Mörk

2003

Cell Motil. Cytoskeleton

254

188

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The differential cellular expression of class III ␤-tubulin isotype (␤III) is reviewed in the context of human embryological development and neoplasia. As compared to somatic organs and tissues, ␤III is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development. As exemplified in cerebellar and sympathoadrenal neurogenesis, the distribution of ␤III is neuron-associated, exhibiting distinct temporospatial gradients according to the regional neuroepithelia of origin. However, transient expression of this protein is also present in the subventricular zones of the CNS comprising putative neuronal-and/or glial precursor cells, as well as in Kulchitsky neuroendocrine cells of the fetal respiratory epithelium. This temporally restricted, potentially non-neuronal expression may have implications in the identification of presumptive neurons derived from embryonic stem cells. In adult tissues, the distribution of ␤III is almost exclusively neuron-specific. Altered patterns of expression are noted in cancer. In "embryonal"-and "adult-type" neuronal tumors of the CNS and PNS, ␤III is associated with neuronal differen- Abbreviations: bHLH, basic helix-loop-helix; ␤III, class III ␤-tubulin isotype, CNE , central nervous system enhancer; CNS, central nervous system; EGL, external granule layer; MAP, microtubule-associated protein; NCAM, neural cell adhesion molecule; OPC, oligodendrocyte precursor cell; PCNA, proliferating cell nuclear antigen; PNS, peripheral nervous system; pRb, retinoblastoma tumor suppressor protein; PSA, polysialated; SVZ, subventricular zone; WHO, World Health Organization. tiation and decreased cell proliferation. In contrast, the presence of ␤III in gliomas and lung cancer is associated with an ascending histological grade of malignancy. Thus, ␤III expression in neuronal tumors is differentiation-dependent, while in non-neuronal tumors it is aberrant and/or represents "dedifferentiation" associated with the acquisition of progenitor-like phenotypic properties. Increased expression in various epithelial cancer cell lines is associated with chemoresistance to taxanes. Because ␤III is present in subpopulations of neoplastic, but not in normal differentiated glial or somatic epithelial cells, the elucidation of mechanisms responsible for the altered expression of this isotype may provide insights into the role of the microtubule cytoskeleton in tumorigenesis and tumor progression. Cell Motil. Cytoskeleton 55: 77-96, 2003.

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Section: Class III ␤-Tubulin In Other Neuronal Tumorsmentioning

confidence: 99%

Class III β‐tubulin in human development and cancer

Katsetos

Herman²,

Mörk

2003

Cell Motil. Cytoskeleton

254

188

View full text Add to dashboard Cite

show abstract

“…A distinctive feature of neurocytoma is the positivity of the oligodendroglial-like cells for neuronal markers [3,5,7,10,11,14,19,27,29,36,40,45,46]. This case showed clear immunopositivity for SY, NSE, and NF.…”

Section: Discussionmentioning

confidence: 89%

“…A neuropil-like background and zones of acellular fibrillary matrix are typical [3,5,11,14,19,27,36,47]. Neurocytoma, particularly at extraventricular location, may also show ganglionic differentiation [13,33].…”

Section: Discussionmentioning

confidence: 99%

Extraventricular Neurocytoma: Morphological and Immunohistochemical Considerations on Differential Diagnosis

Buccoliero

Caldarella

Ammannati³

et al. 2002

Pathology - Research and Practice

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“…In some conditions, necrosis was associated with anaplastic features. Necrosis may also be observed in rare cases that are otherwise without malignant features, may be s as a vascular effect ( 41,44,46,47,48,49). …”

Section: Histopathologymentioning

confidence: 99%