Cytoreductive surgery in advanced epithelial cancer of the ovary: The impact of aortic and pelvic lymphadenectomy

Prognostic significance of systematic lymphadenectomy as part of primary debulking surgery in patients with advanced ovarian cancer

“…This is in accord with the 35-75% rate of node involvement in advanced ovarian cancer patients from others [3,[9][10][11][12]17]. We found that patients who underwent systematic lymphadenectomy as part of primary cytoreductive procedures had significantly improved survival, and these survival differences seemed to be due to the status of residual disease.…”

“…Unfortunately, the Benedetti-Panici study does not seem to give direct evidence to answer this issue because of the following disputed points: first, the survival impact of lymphadenectomy in the subgroup of patients with complete cytoreduction was not analyzed; second, the follow-up time was relatively short; and third, the aspects of diversity in stage IIIC diseases -disease with node positive only or the extent of peritoneal carcinomatosis -was not analyzed. In contrast, other single institutional series have demonstrated that systematic pelvic and para-aortic lymphadenectomy might improve survival of patients with advanced ovarian cancer, and this survival benefit was prominent in optimally debulked patients [10][11][12][13]. Aletti et al retrospectively reviewed 219 patients with stages IIIC-IV ovarian cancer who underwent primary cytoreductive surgery [13].…”

“…Some investigators have reported that systematic lymphadenectomy removes bulky or microscopic nodal diseases and might result in the improvement of survival in patients with advanced ovarian cancer [9][10][11][12][13][14]. A meta-analysis from nine studies concluded that systematic lymphadenectomy might improve overall survival in advanced ovarian cancer [15].…”

Les métastases ganglionnaires du cancer épithélial de l'ovaire sont-elles chimio-sensibles ? Étude comparative de la lymphadénectomie première ou après chimiothérapie

“…Plusieurs études rétrospectives soulignent l'intérêt théra-peutique de la résection des métastases ganglionnaires dans les formes peu évoluées [25] et dans les stades III/IV [13,26,27]. Mais aucune de ces séries n'est randomisée.…”

Robotic retroperitoneal lymph node dissection in gynaecological neoplasms: comparison of extraperitoneal and transperitoneal lymphadenectomy

“…Retroperitoneal lymph node involvement occurs in 5-25 and 50-80 % of women with early and advanced ovarian cancer, respectively. Retrospective studies showed that lymph node dissection is associated with an improvement of staging, complete cytoreduction and a survival benefit, even though current ongoing prospective trial on ovarian cancer (LION study) will help give a definitive answer on this issue and investigate if these data-especially the node ratio-have therapeutic implications and may be considered in future staging [9][10][11][12]37].…”