Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal and appendiceal peritoneal metastases – The Hong Kong experience and literature review

Chow, Felix Che-Lok; Yip, Jeremy; Foo, Chi Chung; Wei, Ran; Choi, Hok Kwok; Ng, Ka Kin; Lo, Oswens Siu-Hung

doi:10.1016/j.asjsur.2020.05.010

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Previous studies from China have investigated the association between treatment strategies and OS in patients with colorectal SPM. [20][21][22][23] However, their clinical significance was limited due to the small number of patients investigated, [20][21][22][23] involving metachronous peritoneal metastases, 20 involving appendiceal tumours 22 or patients being treated only CRS plus HIPEC. 23 Although numerous international multicentre cohort studies have been conducted on patients with colorectal SPM, they mainly focused on the benefits of CRS plus HIPEC or primary tumour resection.…”

Section: Discussionmentioning

confidence: 99%

Treatment and prognosis of colorectal cancer with synchronous peritoneal metastases: 11-year single institute experience

Qin,

Yang,

et al. 2023

egastro

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BackgroundTreatment of colorectal cancer (CRC) with synchronous peritoneal metastases (SPM) is controversial, and its prognosis remains poor. Here, we analysed the association between treatment strategies and the outcomes of patients with colorectal SPM and devised a nomogram to improve their prognosis prediction.MethodsWe retrospectively analysed patients with colorectal SPM treated at The Sixth Affiliated Hospital, Sun Yat-sen University from June 2007 to June 2018. The Kaplan-Meier method with log-rank tests was used to compare the overall survival (OS) among patients undergoing different therapeutic regimens. Cox proportional hazards regression analysis was used to identify the prognostic factors. After variable selection, a nomogram was developed to predict the OS of patients with colorectal SPM.ResultsA total of 371 patients with colorectal SPM were eligible for this study. The median OS of all patients was 15.0 months (95% CI, 13.1 to 16.9), with a 3-year and 5-year OS rate of 23.7% and 16.9%, respectively. Patients who underwent complete cytoreductive surgery (CC0–1) had a better median OS of 49 months (p<0.001). Cox multivariate analysis showed that age >65 years; cancer antigen 125 level >35 U/mL; peritoneal carcinomatosis index >16 scores; and undergoing cytoreductive surgery, chemotherapy and hyperthermic intraperitoneal chemotherapy were independent prognostic factors for OS. The c-index of the prognostic nomogram was 0.747 (95% CI, 0.474 to 1.020).ConclusionsOur study suggests that patients with colorectal SPM who receive comprehensive treatment might achieve better prognoses. The prognostic nomogram demonstrated good predictive performance for patients with colorectal SPM.

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Section: Discussionmentioning

confidence: 99%

Treatment and prognosis of colorectal cancer with synchronous peritoneal metastases: 11-year single institute experience

Qin,

Yang,

et al. 2023

egastro

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“…These combined modalities are the standard of care for peritoneal mesothelioma and pseudomyxoma peritonei and have also been used to treat peritoneal metastases from colorectal cancer in select patients [ 10 ]. Extensive multicenter studies in colorectal cancer patients have shown a median survival of 30-40 months [ 11 ]. The principles of this approach have been thoroughly described by Sugarbaker [ 12 ], which are as follows: (1) selecting patients whose disease is limited to the surface of the abdomen or pelvis and (2) performing CRS to maximally reduce disease burden by resecting involved viscera plus peritonectomy.…”

Section: Introductionmentioning

confidence: 99%

Hyperthermic Intraperitoneal Chemotherapy in Gastric Cancer: A Clinical Case Involving Long-Term Survival

Duarte Mendes,

Vicente,

Fernandes

et al. 2023

Cureus

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Peritoneal metastasis is the most common pattern of synchronous and metachronous dissemination in gastric cancer (GC) and is associated with a poor prognosis. Even though systemic chemotherapy is the standard of care, the optimal therapeutic approach to peritoneal disease in this setting is yet to be defined. We present a case of a 26-year-old female diagnosed with locally advanced GC who developed peritoneal carcinomatosis (PC). The patient underwent cytoreductive surgery (CRS) along with hyperthermic intraperitoneal chemotherapy (HIPEC) with complete remission. She remained disease-free after six years, presenting with peritoneal recurrence 70 months after the procedure. This report describes a rare case of long-term survival following a controversial therapeutic approach.

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Cytoreductive surgery for colorectal liver metastases: is it worthwhile?

Adam¹,

Accardo²,

Allard³

2022

Minerva Surg

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Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal and appendiceal peritoneal metastases – The Hong Kong experience and literature review

Cited by 3 publications

References 33 publications

Treatment and prognosis of colorectal cancer with synchronous peritoneal metastases: 11-year single institute experience

Treatment and prognosis of colorectal cancer with synchronous peritoneal metastases: 11-year single institute experience

Hyperthermic Intraperitoneal Chemotherapy in Gastric Cancer: A Clinical Case Involving Long-Term Survival

Cytoreductive surgery for colorectal liver metastases: is it worthwhile?

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