Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus Surgery Without HIPEC for Goblet-Cell Carcinoids and Mixed Adenoneuroendocrine Carcinomas: Propensity Score–Matched Analysis of Centers in the Netherlands and Belgium

Sluiter, Nina R.; Bilt, Jarmila D. van der; Croll, Dorothée M.R.; Vriens, Menno R.; Hingh, Ignace H. J. T. de; Hemmer, Patrick H. J.; Aalbers, Arend G. J.; Bremers, Andreas J A; Ceelen, Wim; D’Hoore, André; Schoonmade, Linda J.; Coupé, Veerle M.H.; Verheul, H.; Kazemier, Geert; Tuynman, Jurriaan B.

doi:10.1016/j.clcc.2020.01.002

Cited by 7 publications

(5 citation statements)

References 49 publications

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“…After matching for sex, tumor stage, lymph node stage, and liver metastases, CRS-HIPEC was associated with improved median OS in both the GCA/MANEC group (HR, 4.27; 95 % CI, 1.88-9.66; p = 0.001) and the GCA-alone group (HR, 2.77; 95 % CI, 1.06-7.26; p = 0.038). 71 This together with other smaller studies have shown that CRS with HIPEC may be considered for select patients with peritoneal metastases from GCA. 68,72,73…”

Section: Goblet Cell Adenocarcinoma/mixed Adenoneuroendocrine Carcinomamentioning

confidence: 76%

The Landmark Series: Appendiceal Primary Peritoneal Surface Malignancy

Gangi

Shah

2021

Ann Surg Oncol

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Appendiceal primary peritoneal surface malignancies are rare and include a broad spectrum of pathologies ranging from indolent disease to aggressive disease. As such, the data that drive the management of appendiceal peritoneal surface malignancies is generally not based on prospective clinical trial data, but rather consists of level 1 data based on retrospective studies and high-volume institutional experiences. Complete surgical debulking typically offers the best chance for long-term survival. This review highlights the landmark articles on which management of primary appendiceal peritoneal surface malignancies are based.Appendiceal neoplasms are rare and involve a spectrum of diseases that can be either low grade with fairly slow growth rates or high grade with aggressive features. Broadly, appendiceal neoplasms account for only 1-2 % of intestinal malignancies. 1,2 Appendiceal malignancies may present with acute appendicitis, or more frequently, with progressive abdominal discomfort. Patients with appendiceal cancers may also be asymptomatic, and diagnosed secondary to identification of an abnormality noted on cross-sectional imaging, at the time of colonoscopy with an abnormal-appearing appendiceal orifice or at the time of surgery for another indication.

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Section: Goblet Cell Adenocarcinoma/mixed Adenoneuroendocrine Carcinomamentioning

confidence: 76%

The Landmark Series: Appendiceal Primary Peritoneal Surface Malignancy

Gangi

Shah

2021

Ann Surg Oncol

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“…In 2020, Garach et al [6] compared the effects of this combination in both mucinous and nonmucinous appendiceal neoplasms and reported that mucinous features lead to a better treatment response and a more favourable prognosis. In the same year, Sluiter et al [7] performed a metaanalysis to assess whether combining HIPEC with cytoreductive surgery in peritoneally metastatic goblet cell carcinomas, which are histologically comparable to MiNENs and MANEC, could lead to better outcomes than surgery alone. The results showed an improved median overall survival (OS) in the surgery + HIPEC group compared to the surgery alone group.…”

Section: Discussionmentioning

confidence: 99%

Multidisciplinary Management of a Mixed Neuroendocrine and Nonneuroendocrine Neoplasm of the Appendix: A Case Report

2024

Ann Case Report

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Introduction: Mixed neuroendocrine and nonneuroendocrine neoplasms (MiNENs) are the rarest neuroendocrine appendiceal neoplasms, for which no standard treatment guidelines are available. Here, we present a case report of a pelvic MiNEN. Case description:A 41-year-old woman underwent clinical evaluation to determine the causes of her infertility. Medical tests revealed a massive cystic mass in the left pelvis and a small fluid-filled nodule originating from the appendix. Fertility-sparing surgery evidenced an appendiceal MiNEN, with a low-grade neuroendocrine component in the context of a low-grade mucinous neoplasm (LAMN). Pathological stage was pT4 N0 M1 (according to the AJCC VIII ed.), as the tumour reached the visceral peritoneum, showing no metastatic lymph node involvement. A single metastatic nodule expressing neuroendocrine features was found in the omentum. Instrumental re-evaluation performed after surgery revealed two additional abdominal spots, suspicious for metastases. After multidisciplinary discussion, a second surgery was performed, followed by intraperitoneal intraoperative hyperthermia (HIPEC). Three months later, CT scan revealed a neoformation between the stomach and the pancreas tail, suspicious for disease progression. Surgical biopsy was deemed unfeasible. Since LAMN was the main component of the pelvic mass previously removed, the patient underwent oral fluoropyrimidine-based chemotherapy. Simultaneously, patient was treated with somatostatin analogues (SAs), after assessing a moderate 68Ga-PET scan positivity. The patient is currently on treatment, alive and progression-free after 28 months. Conclusion:Our case highlights the importance of multidisciplinary approach and literature review to guarantee the most appropriate management of rare diseases such MiNENs, underlining the unmet need of common guidelines.

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“…There is still insufficient evidence to implement a complex and invasive treatment such as CRS-HIPEC for peritoneal metastasis caused by MANEC as in this patient. However, although not many, there are studies and case reports showing positive results on the effect of CRS-HIPEC due to peritoneal metastasis of MANEC [ 16 , 17 ]. The effect of surgical and chemotherapeutic interventions on survival was examined.…”

Section: Discussionmentioning

confidence: 99%

“…According to the study of Sluiter et al [16], treatment with CRS-HIPEC for patients with peritoneal metastases of GCCs and MANECs in specialized HIPEC centers seems associated with substantially better outcome compared to surgery without HIPEC at the expense of acceptable morbidity and mortality. And these data support that care of patients with peritoneal metastases of GCCs and MANECs should be offered in expert centers that have the option for CRS-HIPEC [16].…”

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confidence: 99%

Peritoneal metastatic mixed adenoneuroendocrine carcinoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a case report

2024

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A 61-year-old man presented with abdominal distension without any symptoms. On colonoscopy and computed tomography findings, it was clinically diagnosed as peritoneal metastasis of sigmoid colon cancer, and diagnostic laparoscopy was performed. Only the peritoneum was partially resected, and the pathology was signet ring cell carcinoma with predominantly local mucinous carcinoma component. However, the patient complained of persistent symptoms and, despite the progress of chemotherapy, the peritoneal dissemination worsened, and additional cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) was performed. Mixed adenoneuroendocrine carcinomas (MANECs) were reported in the appendix with perforated visceral peritoneum. After additional chemotherapy, the patient was discharged. Patients with advanced MANEC with peritoneal spreading may benefit from aggressive treatment by cytoreduction surgery with HIPEC, followed by intravenous chemotherapy.

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Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus Surgery Without HIPEC for Goblet-Cell Carcinoids and Mixed Adenoneuroendocrine Carcinomas: Propensity Score–Matched Analysis of Centers in the Netherlands and Belgium

Cited by 7 publications

References 49 publications

The Landmark Series: Appendiceal Primary Peritoneal Surface Malignancy

The Landmark Series: Appendiceal Primary Peritoneal Surface Malignancy

Multidisciplinary Management of a Mixed Neuroendocrine and Nonneuroendocrine Neoplasm of the Appendix: A Case Report

Peritoneal metastatic mixed adenoneuroendocrine carcinoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a case report

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